Fabrication, Physical Characterizations, and In Vitro, In Vivo Evaluation of Ginger Extract-Loaded Gelatin/Poly(Vinyl Alcohol) Hydrogel Films Against Burn Wound Healing in Animal Model

Abstract

Crude ginger has been used to treat wounds since ancient times till nowadays. The present study aimed at designing and characterizing topical hydrogel films loaded with ginger extract for wound healing in animal model. The hydrogel films were prepared using PVA and gelatin. The prepared films were evaluated for FTIR analysis, surface morphology, pH, swelling behavior, in vitro release, and % drug content. The wound-healing activity of the extract-loaded hydrogel films was compared with commercially available Silver Sulfadiazine® cream. The drug was compatible with the selected polymers and indicated the suitability of the selected polymers for preparation of topical hydrogel films. The SEM images clearly indicated porous structure of the prepared hydrogel films. Slight changes were observed in pH, ranging from 4.98 ± 0.079 in the beginning of the study to 4.9 ± 0.58 in the end. The swelling percentage after 8 h was 257.7%. The films released 78.7 ± 1.7% of the drug in 250 min. The percent drug content was 97.78 ± 5% which did not change significantly during the storage period. The hydrogel films showed similar wound-healing activity as compared to the commercial product (p > 0.05; ANOVA), while greater wound-healing activity as compared to the control group (p < 0.05; ANOVA) evidenced by intensive collagen formation in histopathological analysis.

Synthesis and In Vitro/Ex Vivo Characterizations of Ceftriaxone-Loaded Sodium Alginate/poly(vinyl alcohol) Clay Reinforced Nanocomposites: Possible Applications in Wound Healing

“…The six prepared formulations (i.e., S100(3), P100(3), S50P50(3), S100D15(3), P100D15(3), and S50P50D15(3)) were examined for swelling capacity [ 23 , 30 , 31 ] at room temperature (RT) with three different buffers of pH 1.2 (HCl solution), pH 4.5 (sodium acetate buffer), and pH 6.8 (phosphate buffer saline, 1× PBS). Next, 30 mg of each film was immersed separately in Petri dishes containing 10 mL of each buffer.…”

“…This antibiotic was commonly prescribed, because of its performance and low toxicity, for respiratory bacterial infections (bronchitis, pneumonia) and urinary tract infections [ 22 ]. Nevertheless, due to the ever-increasing emergence and spread of antimicrobial drug resistance (AMR), including CTX resistance by virtue to its extensive use over the past decade, several promising nanotechnology-based delivery strategies (e.g., through polymeric films and/or lipid nanocarriers) have been initiated [ 23 ].…”

An In Vitro and In Vivo Study of the Efficacy and Toxicity of Plant-Extract-Derived Silver Nanoparticles

“…These nanoparticles are rapidly finding applications in diverse areas, including textile, cosmetics, agriculture, food packaging, pharmaceutical, chemical, engineering, and medical applications [ 1 , 2 , 3 , 4 , 5 , 6 ]. Metal and metal oxide nanoparticles, such as silver, gold, zinc oxide, and copper oxide, encompass diverse therapeutic applications, such as targeted drug release and antibacterial and antimicrobial activities, and are thus considered ideal candidates for wound dressings [ 7 , 8 , 9 ] and wound healing [ 10 , 11 ]. Metal nanoparticles prepared using plant extracts exhibit good antimicrobial activity, possibly due to the eco-friendly nature of the reactants as compared with chemically synthesized particles [ 12 , 13 , 14 ].…”

Differentiating Co-Delivery of Bisphosphonate and Simvastatin by Self-Healing Hyaluronan Hydrogel Formed by Orthogonal “Clicks”: An In-Vitro Assessment

“…Hydrogels are a particularly attractive class of biomaterials for the controlled delivery of various drugs due to their tunable physical properties, programmed degradability, and ability to protect labile drugs, properties that can be controlled through the molecular design of polymer networks [ 9 , 10 , 11 ].…”