Abstract. Let A = K[X 1 , . . . , X n ] and let I be a graded ideal in A. We show that the upper bound of the multiplicity conjecture of Herzog, Huneke and Srinivasan holds asymptotically (i.e., for I k and all k 0) if I belongs to any of the following large classes of ideals:(1) radical ideals, (2) monomial ideals with generators in different degrees, (3) zero-dimensional ideals with generators in different degrees. Surprisingly, our proof uses local techniques like analyticity, reductions, equimultiplicity and local results like Rees's theorem on multiplicities.