Facial Asymmetry in Children with Unicoronal Synostosis who have Undergone Craniofacial Reconstruction in Infancy

Öwall, Louise; Darvann, Tron A.; Larsen, Per; Hove, Hanne; Hermann, Nuno V.; Bøgeskov, Lars; Kreiborg, Sven

doi:10.1597/15-089

Cited by 26 publications

(20 citation statements)

References 27 publications

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“…Occlusal abnormalities seem to be overrepresented among children with previous DP, even though the connection is not confirmed with statistical significance [17,18]. However, it has been reported that children with operated unilateral craniosynostosis in infancy have more facial asymmetry than controls [19]. Hence, it is assumed that a similar tendency, only milder, might be found among children with a history of DP.…”

Section: Introductionmentioning

confidence: 89%

Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D Imaging

Launonen

Vuollo

Aarnivala

et al. 2019

JCM

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Deformational plagiocephaly (DP) is considered a risk factor for facial asymmetry. This cohort-based, prospective, follow-up study used three-dimensional (3D) stereophotogrammetry to assess the development of facial asymmetry in a normal birth cohort and to investigate the impact of DP on facial asymmetry for the age range of one to three years. The study sample consisted of 75 children: 35 girls (47%) and 40 (53%) boys recruited from Oulu University Hospital. A total of 23 (31%) subjects had a history of DP in infancy. 3D facial images were obtained at the mean (SD) age of 1.01 (0.04) year old at T1 and 3.02 (0.14) years old at T2. To determine facial asymmetry, both landmark-based and surface-based facial symmetry methods were used. As measured with the surface-based methods, upper facial symmetry improved from T1 to T2 (p < 0.05). As measured with the landmark-based methods, facial symmetry improved on the upper and lower jaw from T1 to T2 (p < 0.05). The asymmetric effect of DP on the upper parts of the face tends to correct spontaneously during growth. Results indicate that previous DP does not seem to transfer to facial or occlusal asymmetry at the age of three years old.

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Section: Introductionmentioning

confidence: 89%

Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D Imaging

Launonen

Vuollo

Aarnivala

et al. 2019

JCM

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“…A set of surfaces were geometrically oriented (rigid registration) and/or transformed (nonrigid registration) to resemble each other, in order for them to share the same coordinate system and achieve detailed left-right point correspondence, after which they can be compared (Hutton et al, 2003; Crum et al, 2004). This is the same method as employed in a previous study by our group (Öwall et al, 2016).…”

Section: Methodsmentioning

confidence: 99%

“…Our group has previously assessed the amount of remaining facial asymmetry after early surgical correction in a Danish group of children with UCS (mean age: 6.5 years), using a method capable of objectively quantifying spatially detailed facial asymmetry in 3-dimension (3D; Öwall et al, 2016). A significant amount of facial asymmetry after the surgical correction was found compared to healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

Spatially Detailed 3D Quantification of Improved Facial Symmetry After Surgery in Children With Unicoronal Synostosis

Öwall

Darvann

Hove

et al. 2019

The Cleft Palate-Craniofacial Journal

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Objective: To assess improvement of soft-tissue facial symmetry in children surgically treated for unicoronal synostosis (UCS) in infancy, to correlate pre- and postsurgical facial asymmetry and to evaluate whether the improvement was visually recognizable. Design: Case–controlled follow-up. Patients/Settings: Eleven Danish children diagnosed with UCS were included, 3 of whom had tested positive for Muenke mutation. Preoperative computed tomography scans and postoperative 3dMD surfaces were available for measurements. A control group of healthy children matched for age and sex was employed. Main Outcome Measures: Pre- and postsurgical facial asymmetry was analyzed using a computerized method capable of objective and spatially detailed quantification in 3-dimension (transverse, vertical, and sagittal directions). Asymmetry was evaluated in the facial region and 6 subregions (forehead, mouth, eyes, nose, cheek, and chin). Results: The largest significant improvement was seen in the sagittal direction of the facial (1.9 mm), forehead (2.0 mm), and cheek (3.4 mm) regions. Small but significant improvements were also seen in the mouth, chin, and eye regions. No significant improvement was seen in the nose region. Significant correlations were found between the pre- and postsurgically calculated facial asymmetry and between calculated asymmetry and clinical validation scores. Conclusions: All patients presented with improved facial symmetry after surgery and the improvements were visually recognizable. However, only 1 (9.1%) of the 11 patients reached a level of facial asymmetry as low as that seen in the control group. The best outcome was, in general, seen in cases with mild facial asymmetry presurgically.

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“…Most attempts to summarize image characteristics rely on global features that describe the image as a whole, or local features calculated point-wise across the image. Previous work evaluating asymmetry in facial images has tended toward a local, point-wise approach (Claes et al, 2011; Kornreich et al, 2016; Öwall et al, 2016). While these features have been shown to be effective, we propose a method to produce a richer phenotype description by scoring an individual's relationship to a model of normal asymmetry using both global and local differences.…”

Section: Methodsmentioning

confidence: 99%

“…Surface registration-based methods show particular promise due to their independence from the plane of symmetry and ability to provide dense shape information across the surface of the face. Recent applications of surface-registration based methods have been validated by comparison to traditional landmark methods and used quantified asymmetry in individuals using the average transform magnitude or root mean squared error from predefined regions (Claes et al, 2011; Kornreich et al, 2016; Öwall et al, 2016; Verhoeven et al, 2016) and principle modes of variation (Lanche et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Associations Between Genetic Data and Quantitative Assessment of Normal Facial Asymmetry

2018

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Human facial asymmetry is due to a complex interaction of genetic and environmental factors. To identify genetic influences on facial asymmetry, we developed a method for automated scoring that summarizes local morphology features and their spatial distribution. A genome-wide association study using asymmetry scores from two local symmetry features was conducted and significant genetic associations were identified for one asymmetry feature, including genes thought to play a role in craniofacial disorders and development: NFATC1, SOX5, NBAS, and TCF7L1. These results provide evidence that normal variation in facial asymmetry may be impacted by common genetic variants and further motivate the development of automated summaries of complex phenotypes.

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Facial Asymmetry in Children with Unicoronal Synostosis who have Undergone Craniofacial Reconstruction in Infancy

Cited by 26 publications

References 27 publications

Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D Imaging

Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D Imaging

Spatially Detailed 3D Quantification of Improved Facial Symmetry After Surgery in Children With Unicoronal Synostosis

Associations Between Genetic Data and Quantitative Assessment of Normal Facial Asymmetry

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