Facial clefting and Amerindian admixture in populations of Santiago, Chile

Palomino, H; Cauvi, Doris; Barton, Sara A.; Chakraborty, Ranajit

doi:10.1002/(sici)1520-6300(1997)9:2<225::aid-ajhb9>3.3.co;2-u

Cited by 18 publications

(32 citation statements)

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“…These results are similar to those obtained in another study carried out in Chile by Palomino et al (1997), who studied the incidence in several health care centers in Santiago. On the other hand, in another study conducted on the Chilean population, Sepúlveda Troncoso et al found a greater incidence of clefts compromising the lip and palate in comparison to isolated cleft palates.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Patients With Cleft Lip and Palate who were Treated at the San Borja Arriarán Clinical Hospital in Santiago Chile, within the AUGE Healthcare Plan

Carrasco

Hernandez

Parada

2015

Int. J. Odontostomat.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Patients With Cleft Lip and Palate who were Treated at the San Borja Arriarán Clinical Hospital in Santiago Chile, within the AUGE Healthcare Plan

Carrasco

Hernandez

Parada

2015

Int. J. Odontostomat.

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“…Diversos autores han vinculado la exposición a plaguicidas durante el embarazo con el bajo peso de los neonatos, los defectos de nacimiento y el aumento en la tasa de abortos espontáneos, incluyen dentro de los defectos de nacimiento el labio o paladar hendido. [27][28][29][30] Otro factor de riesgo asociado con la exposición de pesticidas puede verse relacionado con la exposición laboral de padres a agentes químicos utilizados en esta región como el glifosato, muy usado en actividades de fumigación. Carrasco y colaboradores mostraron cómo el glifosfato afectaba la morfogé-nesis al alterar el metabolismo del ácido retinoico.…”

Section: Discussionunclassified

Factores Ambientales Asociados Con Labio O Paladar Hendido No Sindrómico en Una Población Del Magdalena Medio Colombiano

et al. 2014

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RESUMENObjetivo: evaluar la posible asociación entre factores ambientales y la presencia de labio o paladar hendido (LPH) no sindrómico en los niños residentes en el Magdalena Medio colombiano.Materiales y métodos: se realizó un estudio de casos y controles con 30 madres de niños con LPH (casos) y 60 madres de niños sin alguna alteración craneofacial (controles). Los casos y controles se obtuvieron de una clínica dental en la región mencionada. Las variables analizadas fueron las sociodemográficas (edad, condición socioeconómica, nivel de escolaridad, lugar de residencia antes y durante el primer trimestre); las relacionadas con la gestación (exposición a pesticidas, consumo prenatal de sustancias psicoactivas, alcohol y tabaco), la presencia de LPH en la familia. Se aplicó la prueba de Chi 2 o test Exacto de Fisher según fuera apropiado, la t de Student o U. de Mann Whitnney de acuerdo con la distribución de las variables. Se realizó una regresión logística para establecer los Odds Ratio (OR) crudos y ajustados. ENVIRONMENTAL FACTORS ASSOCIATED WITH ORAL CLEFTS IN CHILDREN LIVING IN COLOMBIAN MAGDALENA MEDIOABSTRACT Objective: to assess the possible association between environmental factors and the presence of non-syndromic cleft lip and/or palate (CL/P) in children living in the Colombian Magdalena Medio.Methods: a case-control study was carried out with 30 mothers of children with CL/P (cases) and 60 mothers of children without any craniofacial alteration (controls). The cases and controls were obtained from a dental clinic in the region mentioned. The variables analyzed were sociodemographic (age, socioeconomic condition, educational level, place of residence before and during the first trimester); pregnancy background (prenatal examinations, diseases, drugs, alcohol and tobacco consumption, psychoactive substances consumption and pesticide exposure), presence of CL/P in the family. Chi-square and Fisher Exact test, Student t test or U Mann Whitney were performed when appropriate. A logistic regression was done to establish the crude and adjusted odds ratio (OR). Conclusions: exposure to pesticides and the presence of CL/P in the family of the affected child increased the risk for non-syndromic oral clefts. Results

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“…The colonization of the new world by the Europeans initially involved men only, and the immigration of European women during the first centuries was insignificant. Admixture analyses performed in Brazil, Chile and Colombia suggest a historical pattern of directional mating that preferentially involved immigrant men and native women (25)(26)(27)(28)(29)(30). The LRT analysis performed assumes that the distribution of paternal alleles was the same as the maternal.…”

Section: Discussionmentioning

confidence: 99%

“…There is a marked difference in the population origin of the female and male founders in South America (25)(26)(27)(28)(29)(30). The association between cleft lip only and RFC1 in South America may be more easily expressed in individuals carrying mitochondrial DNA Amerindian-specific haplotypes A, B, and/or C and male founders originated in Spain and Portugal.…”

Section: Discussionmentioning

confidence: 99%

Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only

Vieira

Cooper

Marazita

et al. 2008

Braz J Med Biol Res

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In this report, we have reanalyzed genotyping data in a collection of families from South America based on maternal origin. Genotyping analysis was performed at the Craniofacial Anomalies Research Center at the University of Iowa. These genotypes were derived from genomic DNA samples obtained from blood spots from children born with isolated orofacial clefts in 45 hospitals located in eight countries (Argentina, Bolivia, Brazil, Chile, Ecuador, Paraguay, Uruguay, and Venezuela) collaborating with ECLAMC (Latin American Collaborative Studies of Congenital Malformations) between January 1998 and December 1999. Dried blood samples were sent by regular mail to the Laboratory of Congenital Malformations, Federal University of Rio de Janeiro. Previous findings suggested that mitochondrial haplotype D is more commonly found among cleft cases born in South America. We hypothesized that association of certain genes may depend upon the ethnic origin, as defined by populationspecific markers. Therefore, we tested if markers in MTHFR (5,10-methylenetetrahydrofolate reductase) and RFC1 (reduced folate carrier 1) were associated with oral clefts, depending on the maternal origin defined by the mitochondrial haplotype. Transmission distortion of alleles in MTHFR C677T and RFC1 G80A polymorphic variants was tested in 200 mother/affected child pairs taking into consideration maternal origin. RFC1 variation was over-transmitted to children born with cleft lip only (P = 0.017) carrying mitochondrial DNA haplotypes other than haplotype D. Our results provide a new indication that variation in RFC1 may contribute to cleft lip only. Future studies should investigate the association between oral clefts and RFC1 based on more discrete phenotypes.

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Facial clefting and Amerindian admixture in populations of Santiago, Chile

Cited by 18 publications

References 0 publications

Prevalence of Patients With Cleft Lip and Palate who were Treated at the San Borja Arriarán Clinical Hospital in Santiago Chile, within the AUGE Healthcare Plan

Prevalence of Patients With Cleft Lip and Palate who were Treated at the San Borja Arriarán Clinical Hospital in Santiago Chile, within the AUGE Healthcare Plan

Factores Ambientales Asociados Con Labio O Paladar Hendido No Sindrómico en Una Población Del Magdalena Medio Colombiano

Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only

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