Facial emotion recognition deficits in patients with bipolar disorder and their healthy parents

Işık-Ulusoy, Selen; Gülseren, Şeref; Özkan, Nermin; Bilen, Cüneyt

doi:10.1016/j.genhosppsych.2020.04.008

Cited by 24 publications

(14 citation statements)

References 32 publications

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“…ITG and MTG participated in high-order visual processing (47), and TTG is involved in auditory information processing (48). Based on previous investigations, the frontal and temporal regions with significant CT differences in the present study were involved in symptoms of emotional (49), cognitive (50), auditory processing (51), and visual impairment (52) in individuals with BD. Moreover, when performing memory, language, cognitive, and affective tasks, BD patients exhibited abnormalities in frontal or temporal regions vs. HCs (53)(54)(55)(56).…”

Section: Common Alteration In Ct In Bd-i and Bd-iisupporting

confidence: 54%

Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis

et al. 2022

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BackgroundBy calculating cortical thickness (CT) and cortical structural covariance (SC), we aimed to investigate cortical morphology and cortical inter-regional correlation alterations in adolescent bipolar disorder type I (BD-I) and type II (BD-II) patients.MethodsT1-weighted images from 36 BD-I and 22 BD-II patients and 19 healthy controls (HCs) were processed to estimate CT. CT values of the whole brain were compared among three groups. Cortical regions showing CT differences in groups were regarded as seeds for analyzing cortical SC differences between groups. The relationship between CT and clinical indices was further assessed.ResultsBoth BD groups showed cortical thinning in several frontal and temporal areas vs. HCs, and CT showed no significant difference between two BD subtypes. Compared to HCs, both BD groups exhibited reduced SC connections between left superior frontal gyrus (SFG) and right postcentral gyrus (PCG), left superior temporal gyrus (STG) and right pars opercularis, and left STG and right PCG. Compared with HCs, decreased SC connections between left STG and right inferior parietal gyrus (IPG) and right pars opercularis and right STG were only observed in the BD-I group, and left PCG and left SFG only in the BD-II group. CT of right middle temporal gyrus was negatively correlated with number of episodes in BD-II patients.ConclusionsAdolescent BD-I and BD-II showed commonly decreased CT while presenting commonly and distinctly declined SC connections. This study provides a better understanding of cortical morphology and cortical inter-regional correlation alterations in BD and crucial insights into neuroanatomical mechanisms and pathophysiology of different BD subtypes.

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Section: Common Alteration In Ct In Bd-i and Bd-iisupporting

confidence: 54%

Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis

et al. 2022

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“…22 Apart from the stable deficit of fear recognition, the patient's ability to recognize facial expressions varied with the stage of illness. Specifically, individuals with BD in a depressive state showed more pronounced (mood congruent) deficits in recognizing happy expressions with no significant deficits recognizing other expressions, 20,21,28 while BD patients in a manic state showed deficits in recognizing fear, anger, and sadness with comparable, nonsignificant results to HC on positive expressions. 20 Across all studies, patients with BD took significantly longer to discriminate expressions and showed lower accuracy than HC when time constraints were applied.…”

Section: Synthesis and Meta-analysis Resultsmentioning

confidence: 88%

“…Citation searching of relevant past reviews generated 20 studies with 19 eligible for full-text screening. The full-text screen produced the final 29 eligible studies, with 11 studies relevant to emotion recognition, [19][20][21][22][23][24][25][26][27][28][29] 12 relevant to ToM, [30][31][32][33][34][35][36][37][38][39][40][41] and 6 relevant to social judgment [42][43][44][45][46][47] (Figure 1). A summary of study outcomes is provided in Table 1.…”

Section: Study Selectionmentioning

confidence: 99%

Deficits of social cognition in bipolar disorder: Systematic review and meta‐analysis

et al. 2021

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Background The association between impaired social cognition and bipolar disorder (BD) is well established. However, to our knowledge, there has not been a recent systematic review that characterizes disparate dimensions of social cognition in BD. Herein, this systematic review and meta‐analysis aimed to synthesize the literature on core aspects of social cognition (i.e., Theory of Mind, emotion recognition, and social judgment) to identify potential areas of impairment. Methods Online databases (i.e., PubMed, Cochrane Libraries, PsycINFO) and Google Scholar were searched from inception to May 2021. Studies with populations ages ≥16 with DSM‐IV or DSM‐5 defined BD (I or II) either in a euthymic or symptomatic state were included. The risk of bias was measured using the ROBINS‐1 tool, and the quality of the sources was evaluated using GRADE criteria. The results of the studies were quantitatively measured by synthesizing Hedge's g effect sizes through a random effects meta‐analytic approach. Results A total of 29 studies were included in the final review (i.e., 12 studies on the Theory of Mind, 11 on emotion recognition, and 6 on social judgment). Overall, results demonstrated social cognition to be moderately impaired in individuals with BD (d = 0.59). The individual domains ranged in effect size (0.38 < d < 0.70), providing evidence for variation in impairment within social cognition. Discussion Individuals with BD exhibit clinically significant deficits in social cognition during euthymic and symptomatic states. Social cognition impairments in individuals with BD are an important therapeutic target for treatment discovery and development.

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“…The total test score was calculated as the number of correct answers (0-19). The score for positive emotions was calculated as the number of correct answers for positive emotions (0-4), and the score for negative emotions was calculated as the number of correct answers for negative emotions (0-15) [36].…”

Section: Facial Emotion Identification Test (Feit)mentioning

confidence: 99%

Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Theory of Mind and Executive Function in Major Depressive Disorder and Its Correlation with Brain-Derived Neurotrophic Factor (BDNF): A Randomized, Double-Blind, Sham-Controlled Trial

et al. 2021

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Background: Studies have implicated hypofrontality in the pathogenesis of impaired theory of mind (ToM) and executive function (EF) in major depressive disorder (MDD). These symptoms are usually resistant to treatment. Repetitive transcranial magnetic stimulation (rTMS) has been shown to reverse hypofrontality. Moreover, BDNF is an effective biomarker of antidepressant effects, but there have been very few studies on the correlation between BDNF and rTMS. We aimed to evaluate the efficacy of 20 sessions of a 10 Hz unilateral rTMS intervention over the left dorsolateral prefrontal cortex (DLPFC) in improving ToM and EF in patients with MDD and its correlation with BDNF. Methods: A total of 120 MDD patients were enrolled in this randomized, sham-controlled, double-blind trial. Each participant received 20 sessions of rTMS at 10 Hz frequency through the active or the sham coil over 4 weeks. ToM was assessed with the facial emotion identification test (FEIT) and hinting task (HT). EF was assessed with the Wisconsin card sorting test (WCST). BDNF assessments were carried out at baseline and 2-, 4-, 12-, and 24-week follow-ups. Results: The improvement in the ToM (FEIT, HT) in the active rTMS group was significantly different from that in the sham rTMS group (F = 18.09, p < 0.001; F = 5.02, p = 0.026). There were significant differences in the WCST (categories completed, response errors, response perseverative errors, non-response perseverative errors) after logarithmic transformation at different time points in the active rTMS group (F = 14.71, p < 0.001; F = 5.99, p = 0.046; F = 8.90, p = 0.031; F = 2.31, p = 0.048). However, there was no significant difference in log transformed BDNF concentration between the two groups (t = 0.07 to t = 1.29, p > 0.05). BDNF was negatively correlated with WCST categories completed at the 24th week (r = −0.258, p = 0.046). Conclusions: The results show that rTMS may improve the ToM and EF of patients with MDD and there was no significant correlation with serum BDNF concentration. RTMS can not only be used for treatment of patients with MDD but also has a positive effect on ToM and EF.

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Facial emotion recognition deficits in patients with bipolar disorder and their healthy parents

Cited by 24 publications

References 32 publications

Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis

Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis

Deficits of social cognition in bipolar disorder: Systematic review and meta‐analysis

Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Theory of Mind and Executive Function in Major Depressive Disorder and Its Correlation with Brain-Derived Neurotrophic Factor (BDNF): A Randomized, Double-Blind, Sham-Controlled Trial

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