Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment

Vashi, Neelam A.; Wirya, Stephen A.; Inyang, Meyene; Kundu, Roopal V.

doi:10.1007/s40257-016-0239-8

Cited by 30 publications

(42 citation statements)

References 121 publications

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“…Melanin produced by melanocytes gets stored in melanosomes, after which it is deposited in epidermis as the determinant of skin color. Despite the protective effect against sun exposure, abnormal melanin accumulation leads to several disorders related to hyperpigmentation, including melasma, freckle, age spot, and lentigo [ 133 ]. Tyrosinase is a principal enzyme involved in melanogenesis ( Fig.…”

Section: Resveratrol and Its Derivatives As The Active Agents For Ski...mentioning

confidence: 99%

The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin

Lin¹,

Hung²,

Sung³

et al. 2021

Journal of Food and Drug Analysis

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Resveratrol has been extensively reported as a potential compound to treat some skin disorders, including skin cancer, photoaging, allergy, dermatitis, melanogenesis, and microbial infection. There has been an increasing interest in the discovery of cosmetic application using resveratrol as the active ingredient because of its anti-aging and skin lightening activities. The naturally occurring derivatives of resveratrol also exert a beneficial effect on the skin. There are four groups of resveratrol derivatives, including hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. The major mechanism of resveratrol and its derivatives for attenuating cutaneous neoplasia, photoaging and inflammation, are related with its antioxidative activity to scavenge hydroxyl radical, nitric oxide and superoxide anion. A systematic review was conducted to describe the association between resveratrol-related compounds and their benefits on the skin. Firstly, the chemical classification of resveratrol and its derivatives was introduced. In this review the cases which were treated for different skin conditions by resveratrol and the derivatives were also described. The use of nanocarriers for efficient resveratrol skin delivery is also introduced here. This review summarizes the cutaneous application of resveratrol and the related compounds as observed in the cell-based, animal-based and clinical models. The research data in the present study relates to the management of resveratrol for treating skin disorders and suggesting a way forward to achieve advancement in using it for cosmetic and dermatological purpose.

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Section: Resveratrol and Its Derivatives As The Active Agents For Ski...mentioning

confidence: 99%

The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin

Lin¹,

Hung²,

Sung³

et al. 2021

Journal of Food and Drug Analysis

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show abstract

“…The psychosocial aspect of hyperpigmentation has important implications for optimal management of patients. Special considerations when evaluating individuals with skin of color with facial hyperpigmentation can improve both cutaneous disease and QoL [ 24 ]. Given that disorders of hyperpigmentation are highly prevalent and affect a large portion of the patient population in dermatology, it is essential that dermatologists recognize the treatment gaps that exist in patients with skin of color as well as the importance of individualized treatment.…”

Section: Discussionmentioning

confidence: 99%

Trends in Use of Prescription Skin Lightening Creams

Saade

Maymone

Garza

et al. 2021

IJERPH

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The desire for an even skin tone pervades all cultures and regions of the world. Uniform skin color is considered a sign of beauty and youth. Pigmentation abnormalities can arise idiopathically with genetic predetermination, with injury and environmental exposures, and with advancing age, and can, therefore, be distressing to patients, leading them to seek a variety of treatments with professional assistance. In this short report, we describe the trends in the use of prescription lightening creams, particularly in patients with darker skin types residing in the US. Amongst 404 participants, skin hyperpigmentation had a moderate effect on patients’ quality of life, and the most common diagnosis associated with the use of a prescription product was melasma (60.8%). The most common agent prescribed was hydroquinone (62.9%), followed by triple combination cream (31.4%). It is the dermatologist’s duty to gauge the effect of the pigmentation disease on patients’ life in order to counsel, tailor, and decide on the most appropriate treatment option.

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“…Management of melasma in darker skin populations is particularly challenging because they are more prone to pigmentary alteration. 25 In India, 20-30% of 40-65 years old women present a facial melasma and current treatments remain unsatisfactory. 26 The present study was conducted in a single centre on a relative limited number of patients.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, 52% of the subjects were Indian. Management of melasma in darker skin populations is particularly challenging because they are more prone to pigmentary alteration . In India, 20–30% of 40–65 years old women present a facial melasma and current treatments remain unsatisfactory …”

Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability on melasma of a topical cosmetic product acting on melanocytes, fibroblasts and endothelial cells: a randomized comparative trial against 4% hydroquinone

Bronzina¹,

Clement²,

Marie

et al. 2020

Acad Dermatol Venereol

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Background Recent data demonstrated that an altered basal membrane, activated melanocytes and secreted factors from keratinocytes but also fibroblasts and endothelial cells are involved in the pathophysiology of melasma. Objectives To evaluate the efficacy and tolerability on melasma of a new topical skin‐lightening cosmetic product combination (CCP) targeting several factors identified to be involved in melasma pathogenesis compared to 4% hydroquinone (HQ). Methods Forty‐three women with melasma were enrolled in a 12‐week double‐blind, randomized, parallel‐group trial and treated with CCP or 4% HQ cream. Efficacy was evaluated with the modified Melasma Area Severity Index (mMASI) score and colorimetric change. Cutaneous tolerability and patient satisfaction were also investigated. Results The mMASI score decreased for both products from baseline and over the study period. At week 12, 90% of the subjects who received the combination products had an improvement in pigmentation vs. 79% with HQ. Similarly, both products significantly increased Individual Typological Angle parameters. For both measures, no statistically significant difference was observed between CCP and HQ in terms of change from baseline. CPP was very well tolerated. Conclusions Cosmetic product combination is as effective as HQ in the management of facial dyspigmentation and represents a safe alternative.

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Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment

Cited by 30 publications

References 121 publications

The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin

The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin

Trends in Use of Prescription Skin Lightening Creams

Efficacy and tolerability on melasma of a topical cosmetic product acting on melanocytes, fibroblasts and endothelial cells: a randomized comparative trial against 4% hydroquinone

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