Facial Soft-Tissue Fillers conference: Assessing the State of the Science

Introduction to Fillers

“…and Prevelle Silk (Mentor Corporation, Santa Barbara, Calif.). 19,[33][34][35][36][37][38][39] Small aliquots of HA may be injected in the face, neck, or décolletée over a series of treatment sessions to improve skin hydration and texture. 26 Hydrelle lasts for about 12 months, but its use has been limited by anecdotal reports of severe inflammatory reactions-painful swelling and blistering-in patients with no known allergies.…”

Late-onset granuloma formation after poly-l-lactic acid injection

“…The mechanism of action involves induction of a subclinical inflammatory response that stimulates fibroblast proliferation and collagen formation, ultimately leading to a progressive increase in volume of the dermis and subcutaneous tissues. 2 Late-onset immune-mediated adverse effects associated with the use of poly- l -lactic acid can appear years after the initial injection with reported range of 6 to 60 months. 3 These effects include inflammatory nodules, papules, and edema.…”

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

“…The FDA received 930 post-marked reports of adverse event from 2003 through 2008, of which 823 were deemed severe and 638 required medical treatment and follow-up. The most frequently reported injection site was the nasolabial fold (35.6 %); however, the majority of reported AEs occurred in sites other than the nasolabial fold, such as lips, periorbital region, and perioral region [3].…”