Facile chemical modification of polysulfone membrane with improved hydrophilicity and blood compatibility

Zhang, Xiang; Xie, Yi; Wang, Rui; Wu, Ming-Bang; Sun, Shudong; Zhao, Changsheng

doi:10.1016/j.matlet.2014.09.037

Cited by 26 publications

(6 citation statements)

References 17 publications

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“…In addition to sulfonation, another modification method of the PSF is chloromethylation, which will induce the appearance of numerous functional groups on the PSF in order to increase hydrophilicity, such as hydroxyl group (–OH), azide group (–N 3 ), amino (–NH 2 ), carboxyl (–COOH) and sulfo (–SO 3 H) groups [ 54 , 67 ]. Through chloromethylation of the PSF, a surface benzyl chloride group is introduced as an active ATRP initiator [ 68 ].…”

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Radu

Voicu

2022

Polymers

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The field of membrane materials is one of the most dynamic due to the continuously changing requirements regarding the selectivity and the upgradation of the materials developed with the constantly changing needs. Two membrane processes are essential at present, not for development, but for everyday life—desalination and hemodialysis. Hemodialysis has preserved life and increased life expectancy over the past 60–70 years for tens of millions of people with chronic kidney dysfunction. In addition to the challenges related to the efficiency and separative properties of the membranes, the biggest challenge remained and still remains the assurance of hemocompatibility—not affecting the blood during its recirculation outside the body for 4 h once every two days. This review presents the latest research carried out in the field of functionalization of polysulfone membranes (the most used polymer in the preparation of membranes for hemodialysis) with the purpose of increasing the hemocompatibility and efficiency of the separation process itself with a decreasing impact on the body.

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Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Radu

Voicu

2022

Polymers

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“…[7][8][9] The current methods to improve the antifouling performance include the blending of hydrophilic polymers, [10][11][12] surface modification by ultraviolet or γ-ray irradiation, [13][14][15][16] plasma surface modification, [17][18][19][20] and chemical modification. [21][22][23] Among these methods, plasma surface modification has the advantages of simplicity, efficiency, and cleanliness. Huner and Gulec 24 modified the surface of a PES ultrafiltration membrane with argon jet plasma under atmospheric pressure, resulting in the introduction of oxygencontaining functional groups (such as hydroxyl, carbonyl, and carboxyl) into the membrane surface.…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of acrylic acid grafted PES ultrafiltration membrane via plasma surface activation

Zhang

2022

High Performance Polymers

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A modified PES ultrafiltration membrane with excellent separation and antifouling properties was obtained after modification by remote Ar–NH3 plasma-induced acrylic acid (AA) grafting. Hydrophilic properties were characterised using water contact angle measurements. The morphology was analysed using SEM and BET measurements. Changes in the surface functional groups were determined using XPS and ATR-FTIR. The separation and antifouling properties were evaluated through a bovine serum albumin (BSA) separation experiment. The results revealed that the surface structure of the modified membrane was not destroyed, that amino groups were introduced on the surface of the PES membrane, and that AA was successfully grafted. The water contact angle decreased from 67° in the original membrane to 5 ± 0.63° in the modified membrane. The water flux increased from 30 to 93.6 L/(m2·h). The rejection rate of BSA increased from 61.5 to 93.8%, and the flux recovery rate increased from 60.0 to 92.3%.

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“…Also, it has been reported that CMC modification gives more biodegradable and nontoxic compounds [19]. Furthermore, a carboxyl group in the CMC influences the hydrophilicity-hydrophobicity balance and dialysis capability of the membrane and its interaction with blood [20]. The preparation of chitosan membrane using CMC as a blending agent and glutaraldehyde as a crosslinking candidate have been conducted in prior studies [19,[21][22][23].…”

Section: ■ Introductionmentioning

confidence: 99%

Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane

2021

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This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chitosan was crosslinked with glutaraldehyde in various monomers ratios, and the membranes formed were characterized by FTIR, SEM, and TGA. Furthermore, the hydrophilicity, swelling, porosity, mechanical strength, and dialysis performance of the membranes against urea and creatinine were systematically examined, and their in-vitro hemocompatibility tests were also conducted. The results showed that the CS/CMC-GA membranes have higher hydrophilicity, swelling, porosity, mechanical strength, and better dialysis performance against urea and creatinine than chitosan without modification. In addition, the hemocompatibility test indicated that the CS/CMC-GA membranes have lower values of protein adsorption, thrombocyte attachment, hemolysis ratio, and partial thromboplastin time (PTT) than that of pristine chitosan. Based on these results, the CC/CMC-GA membranes have better hemocompatibility and the potential to be used as hemodialysis membranes.

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Facile chemical modification of polysulfone membrane with improved hydrophilicity and blood compatibility

Cited by 26 publications

References 17 publications

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Preparation and performance of acrylic acid grafted PES ultrafiltration membrane via plasma surface activation

Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane

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