Facile Fabrication of PEGylated Fluorescent Organic Nanoparticles with Aggregation‐Induced Emission Feature via Formation of Dynamic Bonds and Their Biological Imaging Applications

Macromol. Rapid Commun.

Deng

et al. 2017

Self Cite

Aggregation-induced emission (AIE) is an abnormal phenomenon that has sparked great attention for diverse applications in different fields. In particular, the fabrication and biological imaging applications of AIE-active fluorescent organic nanoparticles (FONs) have become a focus in the emerging and promising fields. A large number of AIE-active polymeric nanoprobes have recently been fabricated through different strategies. The advances and progress in this direction have also recently been summarized by some groups. However, the fabrication and biomedical applications of AIE-active FONs based on carbohydrate polymers and AIE-active dyes are quite rare and limited. In this feature article, the recently reported AIE-active FONs with different structures and applications based on AIE-active dyes and carbohydrate polymers are highlighted, and the major current limitations and development tendencies are also discussed.

Section: Introductionmentioning

confidence: 89%

Recent Advances and Future Prospects of Aggregation‐induced Emission Carbohydrate Polymers

Gao

Macromol. Rapid Commun.

Deng

et al. 2017

Self Cite

“…On the contrary, another type of fluorescent dyes with aggregation-induced emission (AIE) characteristics have attracted much research interest for fabrication of luminescent nanomaterials since the concept was coined by Tang group in 2001. [22][23][24] Compared with the conventional organic dyes, AIE-active dyes are weak fluorescence or non-fluorescence in dilute solutions whereas emit strong fluorescence in concentrated solutions or solids. [25] The mechanism of AIE phenomenon is interpreted as restriction of intramolecular rotations (RIR).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, surface modification and biological imaging of aggregation-induced emission (AIE) dye doped silica nanoparticles

Mao

Xü

Applied Surface Science

et al. 2017

Self Cite

“…Fluorescent nanoprobes have widely applied in the biomedical fields such as targeted cell imaging, disease diagnosis, targeted tracing, and cancer treatment . Over the past years, fluorescent nanoprobes were majorly fabricated using conventional fluorogens, such as fluorescent proteins, semiconductors quantum dots (SQDs), and organic dyes as templates because of their obvious advantages included the great biocompatibility of fluorescent proteins, long‐term photostability of SQDs, and large stokes shift of organic dyes .…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of AIE-Active Fluorescent Polymeric Nanoparticles with Ultra-Low Critical Micelle Concentration Based on Ce(IV) Redox Polymerization for Biological Imaging Applications

Macromol. Rapid Commun.

Xü

Mao

et al. 2017

Self Cite

Fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) property have received increasing attention and possess promising biomedical application potential in the recent years. Many efforts have been devoted to the fabrication methodologies of FPNs and significant advance has been achieved. In this contribution, a novel strategy for the fabrication of AIE-active amphiphilic copolymers is reported for the first time based on the Ce(IV) redox polymerization. As an example, ene group containing AIE-active dye (named as Phe-alc) is directly grafted onto a water soluble polymer polyethylene glycol (PEG) in H O/THF system under low temperature. Thus-obtained amphiphilic fluorescent polymers will self-assemble into FPNs with ultra-low critical micelle concentration, ultra-brightness, and great water dispersibility. Biological evaluation results suggest that the PEG-poly(Phe-alc) possess excellent biocompatibility and can be used for tracing their behavior in cells using confocal laser scanning microscope. These features make PEG-poly(Phe-alc) FPNs promising candidates for many biomedical applications, such as cell imaging, drug delivery vehicles, and targeted tracing. More importantly, many other functional groups can also be incorporated into these AIE-active FPNs through the redox polymerization. Therefore, the redox polymerization should be a facile and effective strategy for fabrication of AIE-active FPNs.