2023
DOI: 10.1002/advs.202305405
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Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing

Xingjie Zan,
Dong Yang,
Yi Xiao
et al.

Abstract: Treating the most widespread complication of diabetes: diabetic wounds poses a significant clinical obstacle due to the intricate nature of wound healing in individuals with diabetes. Here a novel approach is proposed using easily applicable injectable gelatin/metal/tea polyphenol double nanonetworks, which effectively remodel the wound microenvironment and accelerates the healing process. The gelatin(Gel) crosslink with metal ions (Zr4+) through the amino acids, imparting advantageous mechanical properties li… Show more

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Cited by 21 publications
(3 citation statements)
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“…Among these nanozymes, those that catalyze the in-situ generation of ROS (such as oxidases and peroxidases) have been widely used in anti-tumor and the development of new nano-antibacterial agents [13][14][15][16][17][18][19]. Within the tumor microenvironment, ROS can regulate the phenotype and function of tumor cells and various immune cells, affecting multiple processes of tumor immune response [20][21][22][23][24]. This can be applied for tumor-targeting drug delivery systems [25,26].…”
Section: Introductionmentioning
confidence: 99%
“…Among these nanozymes, those that catalyze the in-situ generation of ROS (such as oxidases and peroxidases) have been widely used in anti-tumor and the development of new nano-antibacterial agents [13][14][15][16][17][18][19]. Within the tumor microenvironment, ROS can regulate the phenotype and function of tumor cells and various immune cells, affecting multiple processes of tumor immune response [20][21][22][23][24]. This can be applied for tumor-targeting drug delivery systems [25,26].…”
Section: Introductionmentioning
confidence: 99%
“…Gelatin and chitosan are natural biopolymers with properties of favorable biocompatibility, biodegradability, and abundant functional groups, making them popular choices as wound dressings. , These two polymers are rich in hydroxyl, amino, and other functional groups that can form many hydrogen bonds with functional groups on the surfaces of nanofibers. This bonding can be used synergistically to boost the mechanical properties of the hydrogels.…”
Section: Introductionmentioning
confidence: 99%
“…Advancements in biomaterials have led to the emergence of hydrogel dressings. These are formulated from substances such as chitosan, collagen, gelatin, hyaluronic acid, etc., which offer enhanced therapeutic benefits in wound management. These hydrogel dressings with high biocompatibility and biodegradability are beneficial for wound management and reduce additional injuries .…”
Section: Introductionmentioning
confidence: 99%