Facile hydrodynamic cavitation ON CHIP via cellulose nanofibers stabilized perfluorodroplets inside layer-by-layer assembled SLIPS surfaces

Ghorbani, Morteza; Aghdam, Araz Sheibani; Gevari, Moein Talebian; Koşar, Ali; Cebeci, Fevzi Çakmak; Grishenkov, Dmitry; Svagan, Anna J.

doi:10.1016/j.cej.2019.122809

Cited by 21 publications

(10 citation statements)

References 29 publications

(44 reference statements)

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“…The best conditions for cavitation generation corresponded to the microfluidic device with short and small sidewall roughness. In another study, Ghorbani et al 24 assessed the potential of a new approach inside microfluidic devices with enhanced surfaces. They characterized the cavitation phenomenon for cellulose nanofiber-stabilized perfluorodroplets (PFC5).…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of a vigorous “cavitation-on-a-chip” device with a multiple microchannel configuration

et al. 2021

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Hydrodynamic cavitation is one of the major phase change phenomena and occurs with a sudden decrease in the local static pressure within a fluid. With the emergence of microelectromechanical systems (MEMS), high-speed microfluidic devices have attracted considerable attention and been implemented in many fields, including cavitation applications. In this study, a new generation of ‘cavitation-on-a-chip’ devices with eight parallel structured microchannels is proposed. This new device is designed with the motivation of decreasing the upstream pressure (input energy) required for facile hydrodynamic cavitation inception. Water and a poly(vinyl alcohol) (PVA) microbubble (MB) suspension are used as the working fluids. The results show that the cavitation inception upstream pressure can be reduced with the proposed device in comparison with previous studies with a single flow restrictive element. Furthermore, using PVA MBs further results in a reduction in the upstream pressure required for cavitation inception. In this new device, different cavitating flow patterns with various intensities can be observed at a constant cavitation number and fixed upstream pressure within the same device. Moreover, cavitating flows intensify faster in the proposed device for both water and the water–PVA MB suspension in comparison to previous studies. Due to these features, this next-generation ‘cavitation-on-a-chip’ device has a high potential for implementation in applications involving microfluidic/organ-on-a-chip devices, such as integrated drug release and tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Design and fabrication of a vigorous “cavitation-on-a-chip” device with a multiple microchannel configuration

et al. 2021

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“…As can be seen in Figures 4-7, the diameter of the craters on the cancer cells in SEM images is approximately 4 µm. Our previous studies [4] show that the size of the collapsing bubbles in cavitating flows in a microfluidic device with similar channel dimensions was around 3.5 µm (See Supplementary Information S2). As a result, it can be concluded that the collapse of cavitating bubbles plays a significant role in the disruption of immobilized cancer cells.…”

Section: B Morphological Change Of Immpobulized Cancer Cells On a Chipmentioning

confidence: 99%

“…Depending on the system geometry and working principle, it generates a high amount of energy upon the collapse of emerging bubbles [2]. Due to a wide variety of potential cavitation applications, many researchers have conducted studies on the cavitation physics to facilitate earlier inception [3], [4] and to intensify cavitating flows [5]. The energy released from the collapse of cavitation bubbles has been effectively employed for various applications such as wastewater treatment [6], food manufacturing [7], energy harvesting [8], [9], bacterial inactivation [10], biomedical treatment [11], and other industrial applications [12].…”

Section: Introductionmentioning

confidence: 99%

Local Carpet Bombardment of Immobilized Cancer Cells With Hydrodynamic Cavitation

Gevari¹,

Aydemir²,

Gharıb³

et al. 2021

IEEE Access

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This study presents a method based on carpet bombardment of immobilized cells with cavitating flows. For this, immobilized cancer cell lines are exposed to micro scale cavitating flows from the tip of a micro nozzle under the effect of cavitation microbubbles. The deformation as a result of cavitation bubbles on exposed cells differs from one cell type to another. Therefore, the difference in cell deformation upon cavitation exposure (carpet bombardment) acts as a valuable indicator for cancer diagnosis. The developed system is tested on HCT-116 (Human Colorectal Carcinoma), MDA-MB-231 (Breast Adenocarcinoma), ONCO-DG-1 (Ovarian Adenocarcinoma) cell lines due to their clinical importance. The mechanical effects of cavitation are examined by considering the single-cell lysis effect (the cell membrane is ruptured, and the cell is destroyed) with the help of the Scanning Electron Microscopy (SEM) technique. Our study proposes a promising label-free method for the potential use in cancer diagnosis with cavitation bubble collapse, where microbubbles could be precisely controlled and directed to the desired locations, as well as the characterization of the biophysical properties of cancer cells. The proposed approach tool has the advantages of label-free approach, simple structure and low cost and is a substantial alternative for the existing tools.

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Section: Process Intensification and Kineticsmentioning

confidence: 99%

“…Similarly, Parsa and Zonouzian [ 156 ] designed and built a 30 L hydrodynamic cavitation reactor with plates made from scrap iron sheets to degrade Rhodamine B. Recently Ghorbani et al [ 157 ] used cellulose nanofibres (CNF) to stabilize perfluorodroplets through Pickering emulsion and “hydrodynamic cavitation on chip.” Hydrodynamic cavitation can as well act as an AOP because of the hydroxyl radicals produced. [ 158 ] However, Arrojo and Benito [ 159 ] point out that hydrodynamically generated hydroxyl radicals are more effective at oxidizing volatile and non‐volatile hydrophobic substances as they only promote gas‐phase and gas‐liquid interactions, while it works poorly in liquid‐phase oxidation.…”

Section: Process Intensification and Kineticsmentioning

confidence: 99%

Process intensification connects scales and disciplines towards sustainability

Boffito

Rivas

2020

Can J Chem Eng

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Process intensification (PI) has been established as a cluster of technologies able to produce more with less. While scientists around the globe advocate for new semantics that are increasingly tied to the notion of sustainability, what does the literature data say about PI? A Vosviewer bibliometric map of PI displays it as closely linked to the subjects of design, optimization, gas-to-liquid technologies, mass transfer, catalysis, and kinetics. We analyze the relationship between PI and these subjects while identifying misconceptions about the intensifying potential of some of them, as is the case for process optimization. We provide examples and summarize the recent technological trends for all these cases. Finally, we provide an outlook on the future of PI in which we identify elements that will be key to accelerate the adoption of PI technologies at the commercial scale.

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Facile hydrodynamic cavitation ON CHIP via cellulose nanofibers stabilized perfluorodroplets inside layer-by-layer assembled SLIPS surfaces

Abstract: Access to the published version may require subscription. N.B. When citing this work, cite the original published paper.

Cited by 21 publications

References 29 publications

Design and fabrication of a vigorous “cavitation-on-a-chip” device with a multiple microchannel configuration

Design and fabrication of a vigorous “cavitation-on-a-chip” device with a multiple microchannel configuration

Local Carpet Bombardment of Immobilized Cancer Cells With Hydrodynamic Cavitation

Process intensification connects scales and disciplines towards sustainability

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