Facile Hydrothermal Synthesis of Iron Oxide Nanoparticles with Tunable Magnetic Properties

Song, Ge; Shi, Xiangyang; Sun, Kai; Li, Changpeng; Uher, Ctirad; Baker, James R.; Holl, Mark M. Banaszak; Orr, Bradford G.

doi:10.1021/jp902953t

Cited by 297 publications

(182 citation statements)

References 52 publications

(93 reference statements)

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“…In another work, magnetite nanoparticles with fairly uniform size were produced by precipitating Fe 2+ ion with ammonium hydroxide in the absence of surfactants. [85] The reaction was performed under hydrothermal conditions at a temperature of 134 °C and a pressure of 2 bars for 3 h. The average size of the produced MNPs was 31.1 ± 6.1, which was dependent on concentration of the reactants and the reaction solvent composition. In a very recent study, iron oxide nanoparticles containing nanosized cavities were produced by developing a surfactant free hydrothermal method.…”

Section: Hydrothermal/or Solvothermal Synthesismentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Hydrothermal/or Solvothermal Synthesismentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

View full text Add to dashboard Cite

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“…Due to its applications in medicine as contrast agent, a considerable number of studies were dedicated to the synthesis of magnetite nanoparticles (Daou et al, 2006;Gnanaprakash et al, 2007;Iida et al, 2007;Ge et al, 2009). Most of the syntheses are based on the co-precipitation method.…”

Section: Formation Of Magnetite Nanoparticlesmentioning

confidence: 99%

“…To get larger particles and reduce their dispersity, Daou et al (2006) proposed to perform an additional hydrothermal step at a temperature of 250 • C. Particles centered on 39 nm were then obtained. Ge et al (2009) proposed to use only ferrous salt as starting material. After the addition of the base under vigorous stirring in air and the formation of a magnetite suspension, hydrothermal conditions (134 • C) are applied.…”

Section: Formation Of Magnetite Nanoparticlesmentioning

confidence: 99%

Hydrothermal Steel Slag Valorization—Part II: Hydrogen and Nano-Magnetite Production

et al. 2017

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The effect of acidic conditions (in a pH range of 3 to 6) and temperature on the kinetics of the hydrothermal oxidation of ferrous iron contained in BOF steel slag has been tested in the 150-350 • C range for acid acetic concentrations from 0 to 4 M. Reaction progress was monitored with the amount of produced H 2 . Higher temperature and lower pH are found to enhance the hydrothermal oxidation kinetics of the slag. These two parameters are believed to increase iron dissolution rate which has already been identified as the rate limiting step of the hydrothermal oxidation of pure FeO. An activation energy of 28 ± 4 kJ/mole is found for the hydrothermal oxidation of the steel slag which compares very well with that of pure FeO under similar conditions. In the case of the slag run in water at 300 • C for 70.5 h, magnetite product has been separated magnetically and characterized. Particles were found to fall in three size ranges: 10-30 nm, 100-300 nm, and 1-10 µm. The smallest fraction (10-30 nm) is comparable to the 10-20 nm size range that is achieved when nanomagnetite are synthesized by co-precipitation methods. Obviously, the production of nanomagnetite enhances the economic interest of the hydrothermal processing of steel slags, which has already proven its capacity to produce high-purity H 2 .

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“…The most common methods include coprecipitation [46,47], thermal decomposition [48], hydrothermal synthesis [49,50], microemulsion [51], and sonochemical [52] synthesis. Thermal decomposition technique involves decomposition of organo-metallic iron precursors in organic solvents at higher temperatures.…”

Section: Spion Synthesis and Surface Modificationmentioning

confidence: 99%

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Palihawadana-Arachchige¹,

Naik²,

Vaishnava³

et al. 2017

Nanostructured Materials - Fabrication to Applications

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Nanotechnology has facilitated the applications of a class of nanomaterials called superparamagnetic iron oxide nanoparticles (SPIONs) in cancer theranostics. This is a new discipline in biomedicine that combines therapy and diagnosis in one platform. The multifunctional SPIONs, which are capable of detecting, visualizing, and destroying the neoplastic cells with fewer side effects than the conventional therapies, are reviewed in this chapter for theranostic applications. The chapter summarizes the design parameters such as size, shape, coating, and target ligand functionalization of SPIONs, which enhance their ability to diagnose and treat cancer. The review discusses the methods of synthesizing SPIONs, their structural, morphological, and magnetic properties that are important for theranostics. The applications of SPIONs for drug delivery, magnetic resonance imaging, and magnetic hyperthermia therapy (MHT) are included. The results of our recent MHT study on Gd-doped SPION as a possible theranostic agent are highlighted. We have also discussed the challenges and outlook on the future research for theranostics in clinical settings.

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Facile Hydrothermal Synthesis of Iron Oxide Nanoparticles with Tunable Magnetic Properties

Cited by 297 publications

References 52 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Hydrothermal Steel Slag Valorization—Part II: Hydrogen and Nano-Magnetite Production

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

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