Facile one-pot chemical approach for synthesis of monodisperse chain-like superparamagnetic maghemite (γ-Fe2O3) nanoparticles

Abbas, Mohamed; Islam, Md. Nazrul; Rao, B. Bhaskara; Abdel-Hamed, M.O.; Kim, CheolGi

doi:10.1016/j.jiec.2015.06.025

Cited by 16 publications

(5 citation statements)

References 18 publications

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“…They can even help in the development of multimodal imaging systems such as dual T 1 −T 2 MRI. 9,25 The goal in recent years has been to develop magnetic carriers that combine the greatest number of useful features in a single system that is biocompatible, effective, and low in toxicity. The use of FDA-approved biodegradable polymers, especially polyesters such as poly(lactic acid), poly(glycolic acid), poly(lactic-co-glycolic acid), and poly-ε-caprolactone (PCL), has been extensively investigated in this area.…”

Section: ■ Introductionmentioning

confidence: 99%

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Sub-Micrometer Magnetic Nanocomposites: Insights into the Effect of Magnetic Nanoparticles Interactions on the Optimization of SAR and MRI Performance

Grillo

Gallo²,

Stroppa³

et al. 2016

ACS Appl. Mater. Interfaces

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There is increasing interest in the development of new magnetic polymeric carriers for biomedical applications such as trigger-controlled drug release, magnetic hyperthermia (MH) for the treatment of cancer, and as contrast agents in magnetic resonance imaging (MRI). This work describes the synthesis of sub-micrometer and magnetic polymer nanocomposite capsules (MPNCs) by combining in one single platform the biodegradable polymer poly-ε-caprolactone (PCL) and different concentrations of ∼8 nm oleic acid (OA)-functionalized magnetite nanoparticles (FeO@OA), employing the oil-in-water emulsion/solvent evaporation method. The MPNCs showed a significant increase in particle size from ∼400 to ∼800 nm as the magnetic loading in the organic-inorganic hybrids increases from 1.0% to 10%. The MPNCs presented high incorporation efficiency of FeO@OA nanoparticles, good colloidal stability, and super-paramagnetic properties. Interestingly, electron microscopy results showed that the FeO@OA nanoparticles were preferentially located at the surface of the capsules. Evaluation of the magnetic properties showed that the saturation magnetization and the blocking temperature of the MPNCs samples increased as a function of the FeO@OA loading. All the MPNCs exhibited heating when subjected to MH, and showed good specific absorption rates. Use of the formulations decreased the longitudinal (T) and transverse (T) relaxation times of water protons' nuclei, with excellent transverse relaxivity (r) values, especially in the case of the formulation with lowest FeO@OA loading. Furthermore, the MPNCs-cell interaction was studied, and MPNCs showed lower cellular toxicity to normal cells compared to cancer cells. These findings help in understanding the relationships between magnetic nanoparticles and polymeric capsules, opening perspectives for their potential clinical uses as simultaneous heating sources and imaging probes in MH and MRI, respectively.

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Section: ■ Introductionmentioning

confidence: 99%

“…Hybrid systems can help extend blood half-life providing increased efficiency in terms of T 2 relaxation times. They can even help in the development of multimodal imaging systems such as dual T 1 – T 2 MRI. , …”

Section: Introductionmentioning

confidence: 99%

Sub-Micrometer Magnetic Nanocomposites: Insights into the Effect of Magnetic Nanoparticles Interactions on the Optimization of SAR and MRI Performance

Grillo

Gallo²,

Stroppa³

et al. 2016

ACS Appl. Mater. Interfaces

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“…Improved properties of M-Chi and M-PEI compared with those of M-Neri may be due to different types of magnetosome organization between M-Chi and M-PEI on the one hand and M-Neri on the other hand. M-PEI and M-Chi appear organized in chains, similarly to what is observed for magnetosomes naturally synthesized by and extracted from magnetotactic bacteria, a type of organization that is difficult to obtain using a chemical synthesis [ 45 ]. This may be due to an average smaller size or a multi-domain structure of chemically synthesized nanoparticles than in M-PEI and M-Chi.…”

Section: Discussionmentioning

confidence: 88%

Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field

et al. 2017

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BackgroundBiologics magnetics nanoparticles, magnetosomes, attract attention because of their magnetic characteristics and potential applications. The aim of the present study was to develop and characterize novel magnetosomes, which were extracted from magnetotactic bacteria, purified to produce apyrogen magnetosome minerals, and then coated with Chitosan, Neridronate, or Polyethyleneimine. It yielded stable magnetosomes designated as M-Chi, M-Neri, and M-PEI, respectively. Nanoparticle biocompatibility was evaluated on mouse fibroblast cells (3T3), mouse glioblastoma cells (GL-261) and rat glioblastoma cells (RG-2). We also tested these nanoparticles for magnetic hyperthermia treatment of tumor in vitro on two tumor cell lines GL-261 and RG-2 under the application of an alternating magnetic field. Heating, efficacy and internalization properties were then evaluated.ResultsNanoparticles coated with chitosan, polyethyleneimine and neridronate are apyrogen, biocompatible and stable in aqueous suspension. The presence of a thin coating in M-Chi and M-PEI favors an arrangement in chains of the magnetosomes, similar to that observed in magnetosomes directly extracted from magnetotactic bacteria, while the thick matrix embedding M-Neri leads to structures with an average thickness of 3.5 µm2 per magnetosome mineral. In the presence of GL-261 cells and upon the application of an alternating magnetic field, M-PEI and M-Chi lead to the highest specific absorption rates of 120–125 W/gFe. Furthermore, while M-Chi lead to rather low rates of cellular internalization, M-PEI strongly associate to cells, a property modulated by the application of an alternating magnetic field.ConclusionsCoating of purified magnetosome minerals can therefore be chosen to control the interactions of nanoparticles with cells, organization of the minerals, as well as heating and cytotoxicity properties, which are important parameters to be considered in the design of a magnetic hyperthermia treatment of tumor.Electronic supplementary materialThe online version of this article (doi:10.1186/s12951-017-0293-2) contains supplementary material, which is available to authorized users.

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“…We chose Zn 0.3 Fe 2.7 O 4 nanoparticles as the threads in magnetic bone cement because of their high heating efficiency and good biocompatibility, which have been reported previously [12]. Zn 0.3 Fe 2.7 O 4 nanoparticles were synthesized using a one-pot approach [13]. Generally, zinc-doped ferrite nanoparticles demonstrated soft magnetic performance, and the specific absorption ratio (SAR) was not very high, which was not the best choice for magnetic hyperthermia.…”

Section: Discussionmentioning

confidence: 99%

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

Ren

Han

et al. 2022

Life

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Bone cement is a crucial material to treat bone metastases defects, and can fill the bone defect and provide mechanical support simultaneously, but the antitumor effect is very limited. Magnetic bone cement not only supports bone metastasis defects but can also achieve magnetic hyperthermia to eliminate tumor cells around the bone defect. However, the physicochemical properties of the bone cement matrix will change if the weight ratio of the magnetic nanoparticles in the cement is too high. We mixed 1 weight percent Zn0.3Fe2.7O4 with good biocompatibility and high heating efficiency into a polymethyl methacrylate matrix to prepare magnetic bone cement, which minimized the affection for physicochemical properties and satisfied the hyperthermia requirement of the alternating magnetic field.

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Facile one-pot chemical approach for synthesis of monodisperse chain-like superparamagnetic maghemite (γ-Fe2O3) nanoparticles

Cited by 16 publications

References 18 publications

Sub-Micrometer Magnetic Nanocomposites: Insights into the Effect of Magnetic Nanoparticles Interactions on the Optimization of SAR and MRI Performance

Sub-Micrometer Magnetic Nanocomposites: Insights into the Effect of Magnetic Nanoparticles Interactions on the Optimization of SAR and MRI Performance

Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

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