Facile Polyethylene Glycol (PEG-400) Promoted Synthesis of Some New Heteryl (E)-styryl Sulfones

Abstract

An efficient and convenient synthesis of heteryl ( E)-styryl sulfones is described. Reaction of an 3-(2-bromoacetyl)coumarin with sodium ( E)-styrenesulfinates yields the corresponding styryl sulfones promoted by polyethylene glycol (PEG-400) as an efficient reaction medium at room temperature

3-(Bromoacetyl)coumarins: unraveling their synthesis, chemistry, and applications

“…A facile synthesis ( E )-styryl sulfones 25a-k was accomplished via the reaction of 3-(bromoacetyl)coumarin derivatives 1 with sodium sulfinates 24 in the presence of polyethylene glycol (PEG-400) for promoting the reaction at ambient temperature ( Scheme 13 ). 68 …”