Facile preparation of a thermosensitive and antibiofouling physically crosslinked hydrogel/powder for wound healing

Dong, Xiaoru; Yao, Fanglian; Jiang, Lijie; Liu, Liang; Sun, Hong; He, Shaoshuai; Shi, Mingyue; Guo, Zhicheng; Yu, Qingyu; Yao, Mengmeng; Che, Pengcheng; Zhang, Hong; Li, Junjie

doi:10.1039/d2tb00027j

Cited by 29 publications

(21 citation statements)

References 43 publications

(49 reference statements)

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“…CS-based thermosensitive gels have been widely studied as drug delivery materials and used in wound healing, anti-tumor, nasal delivery, and other applications. [54][55][56] Here we selected CS as the material to prepare temperature-sensitive CS/CSCPs/β-GP gel to enhance its local treatment effect after dermal application. The CS/ CSCPs/β-GP gel had a phase transition temperature of 36.3 °C, which is similar to body temperature.…”

Section: Discussionmentioning

confidence: 99%

Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin

Kong¹,

Lv²,

Guo³

et al. 2023

DDDT

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Background Photoaging decreases quality of life and increases the risk of skin cancer, underscoring the urgent need to explore natural, high-efficacy, anti-skin photoaging (SP) active substances. Methods In this study, a gel (CS/CSCPs/β-GP gel) was prepared using chitosan (CS) and sodium β-glycerophosphate (β-GP) through crosslinking with small molecular CSCPs as the carried drug. We evaluated its structural characteristics and properties. The effect of CS/CSCPs/β-GP gel on the degree of ultraviolet (UV)-induced skin aging of mice was investigated through comparative analysis of skin damage, the integrity of collagen tissues and elastic fibers, levels of reactive oxygen species (ROS) and key inflammatory factors (tumor necrosis factor [TNF]-α and interleukin [IL]-1β, IL-6, and IL-10), and tissue expression of matrix metalloproteinase-3 (MMP-3) after repeated UV irradiation in a nude mice SP model. Results The results showed that CS/CSCPs/β-GP gel was successfully prepared and had the desired characteristics. Compared with CSCPs alone, the CS/CSCPs/β-GP gel more evidently improved typical photoaging characteristics on mouse dorsal skin. It also increased the moisture content, causing the skin to become glossy and elastic. Pathological skin analysis revealed that this peptide-carrying gel can effectively inhibit epidermal thickening, reduce tissue inflammatory infiltration, suppress collagen fiber degradation, increase the collagen content, alleviate structural elastic fiber damage, and significantly inhibit abnormal MMP-3 expression. In addition, biochemical analysis showed that the CS/CSCPs/β-GP gel can effectively inhibit the elevated expressions of ROS and key proinflammatory factors (TNF-α, IL-1β, IL-6) in photoaging skin tissues and promote expression of the anti-inflammatory factor IL-10. Conclusion SP can cause many clinical skin diseases, such as solar freckle-like nevus, solar keratosis, cutaneous melanoma, and squamous cell carcinoma. CSCPs are a high-efficacy anti-SP natural active substance and CS/CSCPs/β-GP gel can synergistically enhance the CSCPs’ anti-SP effect. The mechanism is likely related to the inhibited activation of ROS/nuclear transcription factor-κB signaling and the expression of downstream inflammatory factors.

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Section: Discussionmentioning

confidence: 99%

Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin

Kong¹,

Lv²,

Guo³

et al. 2023

DDDT

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“…HBC was synthesized was synthesized via an etherification reaction according to the previous reports and the relative details are given in Supporting Information. [ 35 ]…”

Section: Methodsmentioning

confidence: 99%

“…reported that zwitterionic hydrogels can promote tissue regeneration and recovery by transforming the macrophage type from M1 to M2. [ 32,33 ] Our previous work also showed that zwitterionic hydrogels have remarkable effects on peritoneal adhesion prevention, [ 34,35 ] which can inhibit initial and late‐stage development by impeding fibroblast and exudate adhesion. [ 36 ] Interestingly, an increasing number of studies have determined that epigallocatechin‐3 gallate (EGCG), which is an important component of tea polyphenols, exhibits excellent antioxidative, anti‐inflammatory, antibacterial, and immunoregulatory activities.…”

Section: Introductionmentioning

confidence: 99%

A Zwitterionic Hydrogel with Anti‐Oxidative and Anti‐Inflammatory Properties for the Prevention of Peritoneal Adhesion by Inhibiting Mesothelial‐Mesenchymal Transition

Yu,

Sun,

Zhang

et al. 2023

Adv Healthcare Materials

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Postoperative peritoneal adhesion are serious clinical complications. Various hydrogel barriers have been developed to prevent peritoneal adhesion. However, it remains a challenge to design a hydrogel with desirable physicochemical properties and bioactivities. In this study, we developed a zwitterionic polysaccharide‐based multifunctional hydrogel using epigallocatechin‐3‐gallate (EGCG) to prevent postoperative abdominal adhesion. This hydrogel is simple to use and has desirable properties, such as excellent injectability, self‐healin and nonswelling properties. The hydrogel also has ultralow fouling capabilities, such as superior bactericidal performance, cell and protein adhesion, and low immunogenicity resistance. Moreover, the hydrogel exhibited good antioxidant activity, which was attributed to the integration of EGCG. Furthermore, the detailed mechanism from in vivo and in vitro experimental studies illustrates that hydrogel compositions can synergistically prevent adhesion formation through multiple pathways, including anti‐inflammatory and antioxidant capabilities and inhibition effects on the mesothelial‐mesenchymal transition process induced by transforming growth factor (TGF‐β). In summary, this zwitterionic multifunctional hydrogel has great potential to prevent postoperative adhesion formation in the clinical setting.This article is protected by copyright. All rights reserved

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“…The construction of polyelectrolyte contains cationic polymers, anionic polymers, [29] and zwitterionic polymers. [11,30,31] Due to the large amounts of ionic groups inside, it can tightly attach to the substrates through electrostatic interactions, dipole interactions, and hydrogen bonds. Gao and co-workers [32] reported a polyzwitterion-clay nanocomposite hydrogel which has excellent self-healing property and reversible skin adhesiveness due to the zwitterionic groups.…”

Section: Introductionmentioning

confidence: 99%

“…And it could exhibit excellent biocompatibility, as our previous studies showed that the PSBMA-based hydrogel has been widely used in the biomedical field. [31,36,37] In addition, the different forms of adhesive would also be suitable for different application conditions.…”

Section: Introductionmentioning

confidence: 99%

Bio‐Inspired Antibacterial Hydrogel Adhesives with High Adhesion Strength

Liu

Qin

Dong

et al. 2022

Macromol. Rapid Commun.

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Traditional adhesives such as cyanoacrylate glue are mostly solvent-based. They are facing the problem of insufficient adhesion to some substrates, and also from the drawback of volatilization and release of small organic molecules in the process of usage. Therefore, a novel adhesive with non-irritating, high adhesive strength, and antibacterial properties is highly required. In this study, a full physically crosslinked zwitterionic poly(betaine sulfonate methacrylate) (PSBMA) hydrogel is proposed. The physical crosslinking interactions endow the hydrogel with good self-healing properties. Furthermore, the pure physical crosslinking hydrogel can form PSBMA powder adhesive after lyophilization and return to the hydrogel state after hydration. The mechanical properties of PSBMA adhesive can be modulated via adjusting the solid content and initiator dosage. Following the cure process similar to that of snail mucus or insect exoskeletons in nature, the adhesion of the PSBMA adhesive is improved at least 100 times than its wet state. In addition, the PSBMA adhesive is easy to be removed due to the dissociation of cross-linked structures in saltwater environments. Moreover, PSBMA adhesive with antifouling properties can effectively prevent the adhesion of proteins and bacteria, which shows potential applications in the assembly of medical devices.

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Facile preparation of a thermosensitive and antibiofouling physically crosslinked hydrogel/powder for wound healing

Abstract: To improve the therapeutic effect of hydrogel for damaged tissue, a series of hydroxybutyl chitosan (HBC) and poly (sulfobetaine methacrylate) (PSBMA) composite hydrogels (HBC-PSB) with thermosensitivity, self-healing, antibiofouling, and synergistic...

Cited by 29 publications

References 43 publications

Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin

Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin

A Zwitterionic Hydrogel with Anti‐Oxidative and Anti‐Inflammatory Properties for the Prevention of Peritoneal Adhesion by Inhibiting Mesothelial‐Mesenchymal Transition

Bio‐Inspired Antibacterial Hydrogel Adhesives with High Adhesion Strength

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