Facile preparation of aqueous fullerene C60 nanodispersions

Андреев, С. М.; Purgina, Daria; Bashkatova, Elena; Garshev, A. V.; Maerle, Artem; Khaitov, Musa

doi:10.1134/s199507801404003x

Cited by 19 publications

(15 citation statements)

References 8 publications

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“…Recently, we have proposed a new simple method for preparation of C 60 aqueous solution using a “dialysis principle” [ 39 ]. Shortly, the protocol design includes the dissolution of crystalline fullerene in N-methylpyrrolidone (NMP), dilution of this solution with distilled water or aqueous solution of an l -amino acid used as a stabilizing agent with subsequent exhaustive dialysis against deionized water.…”

Section: Resultsmentioning

confidence: 99%

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Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis

et al. 2016

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Background Water-soluble form of fullerene C60 is a promising tool for the control of ROS-dependent inflammation including allergic diseases. Anti-inflammatory effects of C60 (nC60) aqueous dispersion were evaluated in the mouse models of atopic dermatitis using subcutaneous (SC) and epicutaneous (EC) applications during 50 days period. A highly stable nC60 was prepared by exhaustive dialysis of water-organic C60 solution against water, where the size and ζ-potential of fullerene nanoparticles are about 100 nm and −30 mV, respectively.ResultsTo induce skin inflammation, female BALB/c mice were EC sensitized with ovalbumin three times during one-weekly exposures. The nC60 solution was administrated in mice subcutaneously (SC) (0.1 mg/kg) and epicutaneously (EC) (1 mg/kg). Significant suppression of IgE and Th2 cytokines production and a concomitant rise in concentrations of Th1 cytokines were observed in nC60-treated groups. In addition, a significant increase in the levels of Foxp3+ and filaggrin mRNA expression was observed at EC application. Histological examination of skin samples indicated that therapeutic effect was achieved by both EC and SC treatment, but it was more effective with EC. Pronounced reduction of the eosinophil and leukocyte infiltration in treated skin samples was observed.ConclusionsWe suppose that nC60 treatment shifts immune response from Th2 to Th1 and restores to some extent the function of the skin barrier. This approach can be a good alternative to the treatment of allergic and other inflammatory diseases.

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Section: Resultsmentioning

confidence: 99%

“…Aqueous fullerene dispersion, nC 60 , was obtained by method described earlier [ 39 ]. Briefly, 20 mg of C 60 were dissolved in 25 ml of N-methylpyrrolidone (magnetic stirrer) and resulting dark brown-purple solution was mixed with solution of 40 mg l -alanine in 100 ml of deionized water.…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis

et al. 2016

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“…Derivatization and solubilization have been disregarded in this field. The most relevant techniques of AFD preparation are solvent exchange [11,14,15], dialysis [16], and mixing [17][18][19]. However, the total yield of fullerene transfer into water of 100 % has not yet been achieved, which leads to significant losses and increases for the cost of the final product, especially for EMFs.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the solvent-exchange process for high-yield synthesis of aqueous fullerene dispersions

Mikheev¹,

Pirogova²,

Bolotnik³

et al. 2018

Nanosystems: Phys. Chem. Math.

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The ultrasound-assisted solvent-exchange technique for aqueous fullerene dispersions (AFD) of C 60 (10 −4 -10 −6 M) have been improved for high-yield synthesis, thereby achieving AFDs with total recovery over 90 %. Using ICP-AES, HPLC-UV, HGC-MS, the elemental and residual organic compounds have been estimated as not exceeding 3 ppm. The possible structure of fullerene clusters in AFD was assumed as {n[C 60 ]mC 6 H 5 COO − (m − x)Na + }xNa + .

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“…[8][9][10][11][12][13][14] While in low-polar aromatic solvents, fullerenes are well solvated and relatively well dissolved, 14,15 in water they generate hydrosols and suspensions. 5,11,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] In highly polar organic solvents, the molecular solubility of fullerenes is negligible, 14,15 but they readily form colloidal solutions. [9][10][11][12][13][14][31][32][33][34][35] The state of fullerenes, either molecular or colloidal, in the so-called 'good' or 'strong' solvents, such as CS 2 , toluene, and benzene, is still a matter of discussion.…”

Section: Introductionmentioning

confidence: 99%

“…9,[11][12][13][14][31][32][33][34][35] Typical examples are aggregates in N-methylpyrrolidin-2-one-acetonitrile mixed solvent, 3 toluene (benzene) mixtures with acetonitrile, 9,12,36 N-methylpyrrolidin-2-one 11,33 and other polar solvents, 13 DMSO, 31 acetonitrile, acetone, ethanol, methanol, and other polar solvents. 32,35,42 Though the stability and coagulation of aqueous C 60 colloids via electrolytes has been examined in full, 14,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][43][44][45][46][47][48][49] the corresponding research for organosols is absent to the best of the authors knowledge. Despite numerous publications describing the preparation procedure, particle size and other properties, the coagulation by electrolytes and the origin of the charge of colloidal species in organic solvents yet stays almost unexplored.…”

Section: Introductionmentioning

confidence: 99%