Facile preparation of PVA hydrogels with adhesive, self-healing, antimicrobial, and on-demand removable capabilities for rapid hemostasis

Abstract

Multifunctional and smart hydrogel-based hemostatic material is of great significance in the field of medical care. In this paper, a facile method for preparation of self-healing, adhesive and on-demand removable...

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

“…[22] Several 3D porous materials, such as gauze, foam, electrospun fibers, etc., have been developed toward this purpose, as porous dressings offer a high surface-to-volume ratio and adequate porosity for gas permeation, besides being amenable to incorporating desired therapeutic agents. [23][24][25][26] In the recent past, traditional dressing materials loaded with antibiotics, including triclosan, [27] doxycycline hyclate, [28] norfloxacin, [28] minocycline, [29] and ciprofloxacin, [30] [31] have been developed to combat the infectious microorganisms at the wound site. However, currently, there is vast attention on developing antibiotic-free dressing materials since prolonged or improper usage of antibiotics can cause antimicrobial resistance (AMR), which is estimated to have resulted in 1.27 million deaths in 2019 across the globe.…”

“…[ 22 ] Several 3D porous materials, such as gauze, foam, electrospun fibers, etc., have been developed toward this purpose, as porous dressings offer a high surface‐to‐volume ratio and adequate porosity for gas permeation, besides being amenable to incorporating desired therapeutic agents. [ 23–26 ]…”

A novel triple-network hydrogel based on borate ester groups: from structural modulation to rapid wound hemostasis

“…19 In recent years, several attempts have been made to develop different types of hydrogel base on borate ester bonds for promoting wound healing. [20][21][22][23] However, hydrogel materials constructed via the non-covalent interaction of boric acid and small molecules alone may suffer from poor stability, 24 and many studies have combined covalent and non-covalent approaches to achieve an enhanced hydrogel strength. [25][26][27] In addition, the stability of borate ester bonds depends on the pH of the environment: strong acidic conditions lead to the breaking of borate ester bonds, and physiological conditions lead to reversible reactions in the direction of ring opening.…”

Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging

“…We also compared the film adhesive with other switchable bioadhesives, and the film adhesive we designed showed the superiority in adhesion strength (fig. S5) (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54). Thus, we fixed the ratio of AA to AM at 3:1 for the subsequent in vivo experiments.…”