Facile Strategy on Hydrophilic Modification of Poly(ε-caprolactone) Scaffolds for Assisting Tissue-Engineered Meniscus Constructs In Vitro

Zhou, Zhu-Xing; Chen, You‐Rong; Zhang, Jiying; Jiang, Dong; Yuan, Fu‐Zhen; Mao, Zimu; Yang, Fei; Jiang, Wenbo; Wang, Xing; Yu, Jia‐Kuo

doi:10.3389/fphar.2020.00471

Cited by 33 publications

(31 citation statements)

References 29 publications

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“…Human cells' adhesion requires lower water contact values 63 . Therefore, postprocessing surface modification, such as soft alkaline treatment to promote surface PCL ester functional groups hydrolysis, should be performed to increase hydrophilicity 64 …”

Section: Resultsmentioning

confidence: 99%

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Lores

Hung

Talou

et al. 2021

Polymers for Advanced Techs

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Tissue engineering requires highly porous complex structures with interconnected pores and tightly controlled pore sizes, added to customized production. Additive manufacturing (AM) is nowadays one of the most suitable technologies for the preparation of structures with strictly defined complex three‐dimensional architectures. Moreover, computed tomography and magnetic resonance imaging can be employed to obtain personalized medical devices. Fused deposition modeling (FDM) is one of the most common, easiest, and cost‐effective AM techniques to obtain 3D objects from a wide variety of materials. However, there is a lack of bioresorbable materials that can fit the increasing demand for biomedical applications requiring stiff elastomers. In this work, a series of bioresorbable segmented poly(ester urethanes) (SPEU) with high hard segment content was synthesized and physicochemically characterized. The materials with higher thermal stability were processed into homogeneous filaments by hot‐melt extrusion with no need for additives nor plasticizers. These filaments were evaluated for FDM, and structures with controlled porosity, filament diameter, and in‐plane pore size could be easily obtained by modifying the printing parameters. Regarding SPEU mechanical properties, the obtained scaffolds could be promising for cartilage tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Lores

Hung

Talou

et al. 2021

Polymers for Advanced Techs

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“…PCL was a kind of biodegradable synthetic polyester for wide applications in tissue regeneration because of its outstanding thermoplastic behavior, high mechanics, suitable biodegradability, and easy processability ( Zhou et al, 2020 ). Koo et al developed a 3D bioprinting cell-laden collagen and hybrid constructs using PCL plates for articular cartilage tissue regeneration, which possessed optimal porous mesh structures and high mechanical properties to support the chondrocyte viability within the bio-inks in vivo ( Koo et al, 2018 ).…”

Section: Polymer-based Bioprinting Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

Advances of Hydrogel-Based Bioprinting for Cartilage Tissue Engineering

Han

Chang

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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Bioprinting has gained immense attention and achieved the revolutionized progress for application in the multifunctional tissue regeneration. On account of the precise structural fabrication and mimicking complexity, hydrogel-based bio-inks are widely adopted for cartilage tissue engineering. Although more and more researchers have reported a number of literatures in this field, many challenges that should be addressed for the development of three-dimensional (3D) bioprinting constructs still exist. Herein, this review is mainly focused on the introduction of various natural polymers and synthetic polymers in hydrogel-based bioprinted scaffolds, which are systematically discussed via emphasizing on the fabrication condition, mechanical property, biocompatibility, biodegradability, and biological performance for cartilage tissue repair. Further, this review describes the opportunities and challenges of this 3D bioprinting technique to construct complex bio-inks with adjustable mechanical and biological integrity, and meanwhile, the current possible solutions are also conducted for providing some suggestive ideas on developing more advanced bioprinting products from the bench to the clinic.

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“…PCL scaffold is shown to be a complete IVD replacement to hold promise for IVD regeneration because electrospun PCL fibers can mimic an AF fiber structural alignment and provide high mechanical properties. In general, PCL-based scaffolds require other synthetic scaffold materials to form the injectable hydrogels, wherein the PCL plays important roles in the enhancement of strength and prolongation of service life for PCL-based hydrogel scaffolds ( Lopez et al, 2010 ; Martin et al, 2014 ; Zhou et al, 2020 ). Yang et al (2017) prepared a tissue engineered IVD to reduce the chronic neck and back pain, which consisted of an alginate hydrogel-based NP and concentric ring-aligned electrospun PCL/PLGA/Collagen type I-based AF.…”

Section: Synthetic Hydrogelsmentioning

confidence: 99%

Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration

Tang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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Intervertebral disk (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the primary cause for loss of quality-adjusted life years. Biomaterials science and tissue engineering have made significant progress in the replacement, repair and regeneration of IVD tissue, wherein hydrogel has been recognized as an ideal biomaterial to promote IVD regeneration in recent years. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and antidegenerative factors determine their suitability for IVD regeneration. This current review provides an overview of naturally derived and synthetic hydrogels that are related to their clinical applications for IVD regeneration. Although each type has its own unique advantages, it rarely becomes a standard product in truly clinical practice, and a more rational design is proposed for future use of biomaterials for IVD regeneration. This review aims to provide a starting point and inspiration for future research work on development of novel biomaterials and biotechnology.

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Facile Strategy on Hydrophilic Modification of Poly(ε-caprolactone) Scaffolds for Assisting Tissue-Engineered Meniscus Constructs In Vitro

Cited by 33 publications

References 29 publications

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Advances of Hydrogel-Based Bioprinting for Cartilage Tissue Engineering

Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration

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