Facile synthesis and characterization of bio-organometallic compounds and their biological activity contour against human pathogens

Abstract

We have reported the synthesis of novel di & trisubstituted pyrroles and their biological activity.

Live cell imaging of bacterial cells: Pyrenoylpyrrole‐based fluorescence labeling

“…The optimized reaction condition and reagents used for the synthesis of ( 3 ) and ( 5 ) shown in the Scheme were followed from our earlier reported work . The overall reaction comprises of two newly formed C‐C bonds.…”

“…An efficient method to synthesize substituted pyrroles involving α‐aroylketene dithioacetals and p ‐toluenesulfonylmethyl isocyanide (TosMIC) with excellent yield has been demonstrated . In our earlier report, we found that di‐ and trisubstituted ferrocenoylpyrrole molecules had a good antibacterial activity but did not have an appreciable photophysical property. An attempt to improvise the same, we would like to introduce a chromophore in the pyrrole molecules to study their photophysical properties and its suitability toward the application in bio‐imaging.…”

Recent Advances for the Synthesis of N‐Unsubstituted Pyrroles

“…The novel di‐substituted pyrrole molecules 277 with ferrocene and aryl ring by the 1,3‐dipolar cycloaddition between α,β‐unsaturated carbonyl compounds 276 and tosylmethyl isocyanide (TosMIC) 263 a were prepared by Divakar et al [89] . The reaction proceeds smoothly under very mild conditions in the presence of sodium hydride in THF over 30 minutes in good yields (Scheme 92).…”

Ferrocene in agriculture: from agrochemicals and soil remediation to selective chemosensors

“…The (η 5 -Cp) 2 Fe has a 18 electrons closed shell, a remarkable stability at the air, especially in the solid state, and a reactivity similar to that of other aromatic species, that allowed extensive functionalization and the introduction of a huge number of substituents [1,2]. All these aspects favored the use of ferrocene and its derivatives in biological applications and in conjugation with biomolecules [3] and prompted the synthesis of compounds with potentiality as drugs [4].…”