TosMIC, a unique and multifunctional synthetic reagent, reacts with a wide spectrum of synthons to deliver novel scaffolds.

Cobalt-catalyzed C–H activation has gone through some major advancements in the past couple of decades.

We have reported the synthesis of novel di & trisubstituted pyrroles and their biological activity.

A novel substituted pyrenoylpyrroles was synthesized by the reaction of pyrenoyl chalcone, TosMIC and methyl iodide under mild condition. All the synthesized compounds were screened for their bioactivity, and the MIC was determined, among which few compounds showed moderate antibacterial activity toward Gram-positive as well as Gram-negative bacteria. Further, cytotoxicity assay ascertained that these compounds were non-toxic to mammalian cells as well. The pyrene chromophore in the synthesized compounds (3a-e) and (5a-e) is responsible for the good photophysical properties which have an absorbance at λ 340 nm and emission at λ 410 nm. Hence, two of the selected novel synthesized compounds with non-cytotoxic nature prospected for bio-imaging of bacterial cells using high-content screening analysis show that the molecule is suitable for microbial imaging in pathological diagnostic studies.

A regioselective synthesis of 3‐pyrazolyl‐4‐aryl substituted pyrrole derivatives from α‐aroylidineketene dithioacetals using a convenient and efficient protocol. The pyrrolylpyrazole molecules were expected to have good application in biological system consequently most of the compounds shows excellent antibacterial activity when compared with streptomycin drug. All the synthesized compounds were studied for their anticancer activity in which 5 b, 5 e, 5 g, 5 i have cytotoxic potential on cervical cancer cells at lower concentration.