Regioselective Synthesis of Pyrrolylpyrazole as a Multifunctional Compound: Potential Antibacterial as well as Anticancer Agent

Abstract

A regioselective synthesis of 3‐pyrazolyl‐4‐aryl substituted pyrrole derivatives from α‐aroylidineketene dithioacetals using a convenient and efficient protocol. The pyrrolylpyrazole molecules were expected to have good application in biological system consequently most of the compounds shows excellent antibacterial activity when compared with streptomycin drug. All the synthesized compounds were studied for their anticancer activity in which 5 b, 5 e, 5 g, 5 i have cytotoxic potential on cervical cancer cells at lower concentration.

N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies

“…The dual-acting anticancer and antimicrobial chemotherapy agents have been published in many studies. 4,[43][44][45][46] Moreover, people with cancer may have a higher risk of infection due to changes in the immune system that controls their body's defenses. 47 Therefore, our potential derivatives have shown to be promising agents in the development of dual therapeutic effects.…”

Base-Promoted Selective Synthesis of 2H-Pyranones and Tetrahydronaphthalenes via Domino Reactions

“…α-Oxoketene dithioacetals (OKDTAs) are one of the versatile intermediates 24 and are used to construct various heterocycles 25 and fluorescence-based sensor 26 molecules through ring annulations and cyclizations. On the basis of the versatility and nature of OKDTAs, over the past few years, our research group is involved in developing new and efficient synthetic methodologies for preparing novel and biologically active heterocycles, such as spiro-oxiindole, 27 2-styrlbenzimidazole, 28 pyrrolylpyrimidine, 28 and pyrrolylpyrrazole 29 derivatives via the domino reaction and multicomponent operation. Recently, we have developed a new methodology for the synthesis of functionalized 2-aryl benzimidazoles 30 from α-aroylketene dithioacetals (AKDTAs, 1 ) via domino reaction.…”