Facile Synthesis and Characterization of L-Aspartic Acid Coated Iron Oxide Magnetic Nanoparticles (IONPs) For Biomedical Applications

Abstract

Natural L-aspartic acid coated iron oxide magnetic nanoparticles (Asp@IONPs) were prepared by a one pot, in-situ and green co-precipitation method in an aqueous medium. Functionalized iron oxide magnetic nanoparticles (IONPs) were characterized by Vibrating Sample Magnetometer (VSM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of IONPs was also investigated on HEK-293 cell lines. The results showed that the zeta potential of Asp@IONPs was about -21.1 mV and the average size was 17.80±3.09 nm. Cell toxicity results show that as prepared IONPs are biocompatible. Asp@IONPs show the possibility of using these nanoparticles in the development of in vitro and in vivo biomedical fields due to do not possess a toxic effect, good ζ-potential and related small and narrow size distribution.

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

“…As a matter of fact, even slightly increased viability was observed at higher Fe concentrations, which is in accordance with other previous reported work and those of others who used different MNPs formulas. 16,40 The outcomes show that the viability of HFF2 and HEK-293 cell lines is not affected by the presence of F-Gly NPs, suggesting that NPs are highly biocompatible and do not possess a toxic effect. These NPs are possibly used for further in vivo applications.…”

“…One of the molecules that can be used for the surface modification of the MNPs are the amino acids due to inexpensive, nontoxic and biocompatible features . Previously, we produced biocompatible amino acid coated MNPs for biomedical applications …”

“…14 Previously, we produced biocompatible amino acid coated MNPs for biomedical applications. 15,16 One of the highest obstacles in chemotherapy of cancer is the biodistribution of the chemotherapeutic compound, which can lead to severe off-target side effects and toxicities, so they still represent a major drawback for their administration. 17 To address these limitations, an smart method is to develop a carrier that can selectively deliver cytotoxic doses of drugs to the tumor cells.…”

Evaluation of UiO‐66 metal organic framework as an effective sorbent for Curcumin's overdose

“…The most varieties of nanoparticles have been synthesized, including polymeric nanoparticles (i.e. hydrogels), solid lipid nanoparticles (SLN), carbon nanotubes, metallic nanoparticles and metal organic framework (MOF) …”

Phenyl alanine & Tyrosine Amino acids Coated Magnetic Nanoparticles: Preparation and Toxicity study

“…One of the molecules that can be used for the surface stabilization, modification and coating of Fe 3 O 4 magnetic nanoparticles properties is the amino acids due to inexpensive, nontoxic and biocompatible features. In recent years, diverse amino acids have been applied to coatings of Fe 3 O 4 magnetic nanoparticles [21][22][23][24][25]. The amino acids adsorb onto the ironoxide surface by formation a chemical bond of the chelate type, by carboxylate group with surface iron ions [26,27].…”