Facile synthesis of boronic acid-decorated carbon nanodots as optical nanoprobes for glycoprotein sensing

Zhang, Xianfeng; Chai, Liucheng; Nie, Shanshan; Lv, Changpeng; Wang, Qiuqin; Li, Zongqun

doi:10.1039/c8an02192a

Cited by 12 publications

(5 citation statements)

References 52 publications

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“…Some studies have justied that quenching occurs due to particle aggregations. 42,45,46 Boron hybridization changes and/or the presence of nonradiative channels induced by electrostatic forces-aggregation/disaggregation caused by the anionic form of the boronic acid upon analyte complexation is another possible mechanism for the quenching. 47 The lack of knowledge on the mechanism of saccharide complexations and how it affects luminescence indicates an open eld for further investigations.…”

Section: Resultsmentioning

confidence: 99%

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From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

et al. 2021

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Section: Resultsmentioning

confidence: 99%

“… 44 Phenylboronic acid and ethylenediamine were used to produce functionalized C-dots for detecting glycoproteins. 45 It is important to note that the examples mentioned above are selective, reproductive and presented good detection limits. However, in all cases, the probes responses are associated with luminescence quenching.…”

Section: Resultsmentioning

confidence: 99%

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

et al. 2021

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“…The three BCDs (including blue-emitting BCDs (B-BCDs), green-emitting BCDs (G-BCDs), and red-emitting BCDs (R-BCDs)) were prepared based on previous work, − and details of the synthesis are given in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Boronic Acid-Decorated Carbon Dot-Based Semiselective Multichannel Sensor Array for Cytokine Discrimination and Oral Cancer Diagnosis

Gao,

Zhu,

Long

et al. 2024

Anal. Chem.

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Cytokines are essential components of the immune system and are recognized as significant biomarkers. However, detection of a single cytokine is not precise and reliable enough to satisfy the requirements for diagnosis. Herein, we developed a pattern recognition-based method for the multiplexed sensing of cytokines, which involves three-color-emitting boronic aciddecorated carbon dots (BCDs) and arginine-modified titanium carbide (Ti 3 C 2 MXenes) as the sensor array. Initially, the fluorescence signals of the three BCDs were quenched by Ti 3 C 2 MXenes. In the presence of cytokines, the fluorescence intensity of the BCDs was restored or further quenched by different cytokines. The fluorescence response occurs in two steps: first, boronic acid interacts with cis-diol functional groups of cytokines, and second, arginine headgroup selectively interacts with glycans. By exploiting the different competing binding of the BCDs and the cytokines toward Ti 3 C 2 MXenes, seven cytokines and their mixtures can be effectively discriminated at a concentration of 20 ng mL −1 . Furthermore, our sensor array demonstrated an excellent performance in classifying human oral cancer saliva samples from healthy individuals with clinically relevant specificity. The noninvasive method offers a rapid approach to cytokine analysis, benefiting early and timely clinical diagnosis and treatment.

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“…The aggregation of QDs resulted in fluorescence quenching. Zhang et al suggested that glycoprotein HRP could induce the aggregation and fluorescence quenching of boronic acid-decorated carbon nanodots (CNDs) [ 168 ]. However, the “turn-off” detection system may interfere with other substances in the complicated matrix, leading to a “false positive” result.…”

Section: Boronate-affinity-based Fluorescent Assays and Imagingmentioning

confidence: 99%

Biosensors with Boronic Acid-Based Materials as the Recognition Elements and Signal Labels

Liu

Chang

et al. 2023

Biosensors

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It is of great importance to have sensitive and accurate detection of cis-diol-containing biologically related substances because of their important functions in the research fields of metabolomics, glycomics, and proteomics. Boronic acids can specifically and reversibly interact with 1,2- or 1,3-diols to form five or six cyclic esters. Based on this unique property, boronic acid-based materials have been used as synthetic receptors for the specific recognition and detection of cis-diol-containing species. This review critically summarizes the recent advances with boronic acid-based materials as recognition elements and signal labels for the detection of cis-diol-containing biological species, including ribonucleic acids, glycans, glycoproteins, bacteria, exosomes, and tumor cells. We also address the challenges and future perspectives for developing versatile boronic acid-based materials with various promising applications.

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Facile synthesis of boronic acid-decorated carbon nanodots as optical nanoprobes for glycoprotein sensing

Abstract: Synthesis-modification-doping-integration: one-step synthesis of boronic acid-decorated carbon nanodots for glycoprotein sensing.

Cited by 12 publications

References 52 publications

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

Boronic Acid-Decorated Carbon Dot-Based Semiselective Multichannel Sensor Array for Cytokine Discrimination and Oral Cancer Diagnosis

Biosensors with Boronic Acid-Based Materials as the Recognition Elements and Signal Labels

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