Facile Synthesis of Dihydroquinolines via Palladium Catalyzed Sequential Amination and Cyclisation of Morita‐Baylis‐Hillman Alcohols

Sruthi, Pambingal Rajan; Sankar, Prem; Saranya, Thachora Venu; Anas, S.

doi:10.1002/slct.202003413

Cited by 2 publications

(1 citation statement)

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“…The pyrrole ring ( Figure 1 ) is a five-membered aromatic heterocycle with electron-rich characteristics. It comprises four carbon atoms and was isolated and characterized for the first time in 1857 [ 12 , 13 ]. The pyrrole moiety is obtained through various synthetic methods widely discussed in the literature [ 14 ], besides being found extensively in natural products [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

et al. 2021

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Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and remains a global health problem four decades after the report of its first case. Despite success in viral load suppression and the increase in patient survival due to combined antiretroviral therapy (cART), the development of new drugs has become imperative due to strains that have become resistant to antiretrovirals. In this context, there has been a continuous search for new anti-HIV agents based on several chemical scaffolds, including nitrogenated heterocyclic pyrrole rings, which have been included in several compounds with antiretroviral activity. Thus, this review aims to describe pyrrole-based compounds with anti-HIV activity as a new potential treatment against AIDS, covering the period between 2015 and 2020. Our research allowed us to conclude that pyrrole derivatives are still worth exploring, as they may provide highly active compounds targeting different steps of the HIV-1 replication cycle and act with an innovative mechanism.

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Section: Introductionmentioning

confidence: 99%

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

et al. 2021

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An Overview of Palladium-Catalyzed Fabrication of Some Heterocyclic Frameworks

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Ахметова

et al. 2023

MROC

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Heterocycles are the largest family of organic compounds due to their wide applications as therapeutic agents, synthetic intermediates, scaffolds, building blocks or fine chemicals. Heterocyclic compounds are continuously used in material science, biotechnology, pharmaceutical and agrochemical industries. In the past few years, the use of transition metal complexes especially palladium as a heterogeneous catalyst has become a trend for the synthesis of various organic compounds. Pd-catalyzed reactions have proven to be effective ways for synthesising a variety of heterocyclic compounds, which are a popular class of molecules in chemical study. Hence, in this review we have discussed the palladium catalyzed synthesis of various heterocyclic compounds i,e. furan, indole, quinoline, coumarin and some other heterocycle derivatives.

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Facile Synthesis of Dihydroquinolines via Palladium Catalyzed Sequential Amination and Cyclisation of Morita‐Baylis‐Hillman Alcohols

Cited by 2 publications

References 37 publications

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

An Overview of Palladium-Catalyzed Fabrication of Some Heterocyclic Frameworks

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