Facile synthesis of Er3+/Tm3+ co-doped magnetic/luminescent nanosystems for possible bioimaging and therapy applications

Liu, Hongyu; Li, Jiabei; Hu, Pengfei; Sun, Songqiang; Shi, Liyi; Sun, Lining

doi:10.1016/j.jre.2020.11.006

Cited by 23 publications

(10 citation statements)

References 55 publications

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“…Bioimaging is a noninvasive technique for visualizing biological processes, allowing observation of subcellular structures, cells, tissues, and even complete multicellular creatures. UCNPs have versatility in generating nanoplatforms that have imaging and therapeutic modalities [ 66 , 67 ]. In addition, they have potential biomedical applications in early-stage diagnosis and monitoring therapy intervention, and have emerged as a novel carrier for small animal imaging, including tumor-targeted imaging, lymphatic imaging, and vascular imaging [ 68 ].…”

Section: Applications Of Ucnpsmentioning

confidence: 99%

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

et al. 2022

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Upconverting luminescent nanoparticles (UCNPs) are “new generation fluorophores” with an evolving landscape of applications in diverse industries, especially life sciences and healthcare. The anti-Stokes emission accompanied by long luminescence lifetimes, multiple absorptions, emission bands, and good photostability, enables background-free and multiplexed detection in deep tissues for enhanced imaging contrast. Their properties such as high color purity, high resistance to photobleaching, less photodamage to biological samples, attractive physical and chemical stability, and low toxicity are affected by the chemical composition; nanoparticle crystal structure, size, shape and the route; reagents; and procedure used in their synthesis. A wide range of hosts and lanthanide ion (Ln3+) types have been used to control the luminescent properties of nanosystems. By modification of these properties, the performance of UCNPs can be designed for anticipated end-use applications such as photodynamic therapy (PDT), high-resolution displays, bioimaging, biosensors, and drug delivery. The application landscape of inorganic nanomaterials in biological environments can be expanded by bridging the gap between nanoparticles and biomolecules via surface modifications and appropriate functionalization. This review highlights the synthesis, surface modification, and biomedical applications of UCNPs, such as bioimaging and drug delivery, and presents the scope and future perspective on Ln-doped UCNPs in biomedical applications.

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Section: Applications Of Ucnpsmentioning

confidence: 99%

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

et al. 2022

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“…As a result, doping representative Gd 3+ (single electrons at 4 f energy level, T1 relaxation) into the UCNP core and shell can allow them to be used as MRI contrast agents. NaYF 4 : Yb, Gd, Tm [ 92 ] and NaGdF 4 : Yb, Er, Tm@NaGdF 4 [ 93 ] UCNPs are such examples. Coating MnO 2 onto UCNPs also entails producing a bright MRI signal (T1), in which MnO 2 can be etched in a solution with a pH of 5.5–7.4, simulating the ones of the TME acid environment.…”

Section: Multimodal Imaging‐guided Cancer Therapiesmentioning

confidence: 99%

Upconversion Nanoparticles for Cancer Therapy

Chen

2022

Advanced NanoBiomed Research

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Lanthanide‐doped upconversion nanoparticles (UCNPs) are anti‐Stokes emitters, which can produce higher‐energy ultraviolet/visible and near‐infrared (NIR) luminescence when excited with low‐energy NIR light. They are featured with nonphotobleaching, sharp emission peaks, superstability, low toxicity, low imaging background, and functional multimodality. These characteristics endow them to be useful as nanoprobes for diagnostic applications and imaging‐guided cancer therapy. Importantly, the ability to convert tissue‐penetrating NIR light into visible and ultraviolet range can expedite Fenton‐ or Fenton‐based processes in chemical dynamic therapy (CDT), activate photosensitizers (PSs) to produce singlet oxygen in photodynamic therapy (PDT), and regulate light‐controlled drug delivery processes for efficacious cancer therapy. The past decade witnessed fast progress of UCNPs as agents in single‐mode therapy or combined therapies in the forefront researches on fighting cancer. This review summarizes the fundamental roles of UCNPs in cancer therapy, highlights types of cell deaths induced by excessive reactive oxygen species (ROS), and showcases cutting‐edge applications in combined cancer therapies as well as imaging‐guided cancer therapy. Challenges and outlook on the use of UCNPs for future directions in cancer therapy are also discussed.

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“…29,30 It means that UCNPs can efficiently convert NIR light with lower energy and stronger penetrating ability to UV or visible (vis) light, avoiding the direct damage of using UV light to biological tissues. 31 Generally, UCNPs are compounds doped with different rare earth ions (Ho 3+ , Er 3+ , Tm 3+ , etc.) owning some special properties, such as imaging and magnetic resonance.…”

Section: Introductionmentioning

confidence: 99%

“…Upconversion nanoparticles (UCNPs) are a type of luminescent nanostructures, which can convert two or more low‐energy continuous near‐infrared (NIR) photons into short wavelength photons with higher energy effectively 29,30 . It means that UCNPs can efficiently convert NIR light with lower energy and stronger penetrating ability to UV or visible (vis) light, avoiding the direct damage of using UV light to biological tissues 31 . Generally, UCNPs are compounds doped with different rare earth ions (Ho 3+ , Er 3+ , Tm 3+ , etc.)…”

Section: Introductionmentioning

confidence: 99%

Multifunctional wound dressing for highly efficient treatment of chronic diabetic wounds

Zhai

Jin

et al. 2022

VIEW

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As the number of diabetics increases yearly and diabetic ulcer is the most concerned diabetic complication, it is of great urgency to develop a novel multifunctional material with high efficiency to promote diabetic wound healing. In this paper, ceria (CeO2)‐modified upconversion nanoparticles which loaded in polycaprolactone membranes were successfully prepared as a ceria‐based wound dressing for chronic wound healing. In this system, near‐infrared (NIR) light is used as a switch to control the photodynamic antibacterial therapy by converting the NIR photons into ultraviolet light, which can further trigger CeO2 to produce reactive oxygen species. In addition, the well‐known antioxidant ability of CeO2 endows the wound dressing with prominent capability to resist the oxidative stress around chronic wounds. In summary, both photodynamic antibacterial therapy and good antioxidant property are realized simultaneously in this CeO2‐based system to promote the healing of diabetic chronic wounds.

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Facile synthesis of Er3+/Tm3+ co-doped magnetic/luminescent nanosystems for possible bioimaging and therapy applications

Cited by 23 publications

References 55 publications

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

Upconversion Nanoparticles for Cancer Therapy

Multifunctional wound dressing for highly efficient treatment of chronic diabetic wounds

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