Facile Synthesis of Hollow MnO<sub>2</sub> Nanoparticles for Reactive Oxygen Species Scavenging in Osteoarthritis

Chen, Lei; Tiwari, Shashi Ranjan; Zhang, Yingqi; Zhang, Jincheng; Sun, Yeqing

doi:10.1021/acsbiomaterials.1c00005

Cited by 36 publications

(22 citation statements)

References 37 publications

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“…Reactive oxygen species (ROS), inducing extensive degradation of the extracellular matrix of cartilage and extracellular toxicity to intra-articular tissues via DNA damage and modifying the lipid, , plays an essential role in the onset and progression of OA. , Thus, clearing the high levels of intracellular ROS may further reinforce therapeutic efficacy in OA . In recent years, ROS-responsive nanoparticles have been extensively studied and applied with the swift development of biomedical materials, − and plenty of nanocarriers have presented the adequate advantage of ROS responsiveness and ROS consumption. − For instance, Tang et al used a combination of living anionic ring-opening polymerization of poly(propylene sulfide) and atom transfer of the radical to prepare polymeric micelles, which efficiently responded to the intracellular ROS and simultaneously released the drugs.…”

Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Huang

Kong

et al. 2022

ACS Appl. Mater. Interfaces

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Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and the drugs are usually insufficient to show local and long-term therapeutic effects because of their rapid clearance. Herein, inspired by the phenomenon that bees track the scent of flowers to collect nectar, we developed cartilage-targeting hydrogel microspheres with reactive oxygen species (ROS)-responsive ability via combining the microfluidic method and photopolymerization processes to integrate cartilagetargeting peptides and ROS-responsive nanoparticles in the hydrogel matrix. The hydrogel microspheres with cartilage-targeting properties promoted better retention in the joint cavity and enhanced cellular uptake of the nanoparticles. Moreover, the ROSresponsive nanoparticles could react with osteoarthritis (OA)-induced intracellular ROS, resulting in the depolymerization of nanoparticles, which could not only eliminate excess ROS and reduce inflammation but also promote the release of dexamethasone (Dex) and kartogenin (KGN) in situ, realizing effective OA therapy. It was demonstrated that this hydrogel microsphere showed favorable ROS-responsive ability and enhanced chondrogenic differentiation as well as the downregulation of pro-inflammatory factors in vitro. Additionally, the hydrogel microspheres, similar to bees, could target and effectively repair cartilage in the OA model. Thus, the injectable hydrogel microspheres exerted an excellent potential to repair OA and may also provide an effective avenue for inflammatory bowel disease therapy.

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Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Huang

Kong

et al. 2022

ACS Appl. Mater. Interfaces

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“… 53 These characteristics enhance the therapeutic potential of the nanostructure, in particular as anti-tumor and anti-osteoarthritis vectors. 54 , 55 However, to the best of our knowledge, MnO 2 nanostructures have not yet been reported as a strategy for IDD therapy. In this study, we developed an intelligent nanoplatform based on MnO 2 NPs for TGF-β3 delivery.…”

Section: Discussionmentioning

confidence: 99%

Controlled Release of TGF-β3 for Effective Local Endogenous Repair in IDD Using Rat Model

Zhu¹,

Yang²,

Yan³

et al. 2022

IJN

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Introduction Intervertebral disc (IVD) degeneration (IDD) is one of the most widespread musculoskeletal diseases worldwide and remains an intractable clinical challenge. Currently, regenerative strategies based on biomaterials and biological factors to facilitate IVD repair have been widely explored. However, the harsh microenvironment, such as increased ROS and acidity, of the degenerative region impedes the efficiency of IVD repair. Here, an intelligent biodegradable nanoplatform using hollow manganese dioxide (H-MnO 2 ) was developed to modulate the degenerative microenvironment and release transforming growth factor beta-3 (TGF-β3), which may achieve good long-term therapeutic effects on needle puncture-induced IDD. Methods Surface morphology and elemental analysis of the MnO 2 nanoparticles (NPs) were performed by transmission electron microscopy and an energy-dispersive X-ray spectroscopy detector system, respectively. The biological effects of MnO 2 loaded with TGF-β3 (TGF-β3/MnO 2 ) on nucleus pulposus cells (NPCs) were assessed via cytoskeleton staining, EdU staining, qPCR and immunofluorescence. The efficacy of TGF-β3/MnO 2 on needle puncture-induced IDD was further examined using MRI and histopathological and immunohistochemical staining. Results The MnO 2 NPs had a spherical morphology and hollow structure that dissociated in the setting of a low pH and H 2 O 2 to release loaded TGF-β3 molecules. In the oxidative stress environment, TGF-β3/MnO 2 was superior to TGF-β3 and MnO 2 NPs in the suppression of H 2 O 2 -induced matrix degradation, ROS, and apoptosis in NPCs. When injected into the IVDs of a rat IDD model, TGF-β3/MnO 2 was able to prevent the degeneration and promote self-regeneration. Conclusion Use of an MnO 2 nanoplatform for biological factors release to regulate the IDD microenvironment and promote endogenous repair may be an effective approach for treating IDD.

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“…Some studies have shown that MnO 2 nanoparticles have the ability to catalyze the reaction of hydrogen peroxide ( Gordijo et al, 2015 ). In the application study of orthopaedic disease treatment, Chen et al designed a hollow MnO 2 nanoparticle with good ROS scavenging ability for the treatment of osteoarthritis ( Chen et al, 2021 ). Kumar et al mentioned that MnO 2 nanoparticles can protect cartilage from oxidative stress caused by inflammation ( Kumar et al, 2019 ).…”

Section: Ros Regulation Nanomaterials and The Related Mechanism Of Ro...mentioning

confidence: 99%

Application and prospect of ROS-related nanomaterials for orthopaedic related diseases treatment

et al. 2022

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The importance of reactive oxygen species (ROS) in the occurrence and development of orthopaedic related diseases is becoming increasingly prominent. ROS regulation has become a new method to treat orthopaedic related diseases. In recent years, the application of nanomaterials has become a new hope for precision and efficient treatment. However, there is a lack of reviews on ROS-regulated nanomaterials for orthopaedic related diseases. Based on the key significance of nanomaterials for the treatment of orthopaedic related diseases, we searched the latest related studies and reviewed the nanomaterials that regulate ROS in the treatment of orthopaedic related diseases. According to the function of nanomaterials, we describe the scavenging of ROS related nanomaterials and the generation of ROS related nanomaterials. In this review, we closely integrated nanomaterials with the treatment of orthopaedic related diseases such as arthritis, osteoporosis, wound infection and osteosarcoma, etc., and highlighted the advantages and disadvantages of existing nanomaterials. We also looked forward to the design of ROS-regulated nanomaterials for the treatment of orthopaedic related diseases in the future.

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Facile Synthesis of Hollow MnO₂ Nanoparticles for Reactive Oxygen Species Scavenging in Osteoarthritis

Cited by 36 publications

References 37 publications

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Controlled Release of TGF-β3 for Effective Local Endogenous Repair in IDD Using Rat Model

Application and prospect of ROS-related nanomaterials for orthopaedic related diseases treatment

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Facile Synthesis of Hollow MnO2 Nanoparticles for Reactive Oxygen Species Scavenging in Osteoarthritis

Cited by 36 publications

References 37 publications

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Controlled Release of TGF-β3 for Effective Local Endogenous Repair in IDD Using Rat Model

Application and prospect of ROS-related nanomaterials for orthopaedic related diseases treatment

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Facile Synthesis of Hollow MnO₂ Nanoparticles for Reactive Oxygen Species Scavenging in Osteoarthritis