Facile synthesis of N2-substituted-1,2,3-triazole from aryl ethynylene and azide via a one-pot two-step strategy

Regioselectively Electrochemical Synthesis of N2-Selective C–H Amination of Ethers with N-Tosyl 1,2,3-Triazole via Triazole Radical Cation

“…The result of the KIE ( k H / k D = 1.27) shows that the C–H cleavage of tetrahydrofuran is not the rate-determining step, which implies that the reaction is not initiated by the THP radical. The result is quietly different from that of our previous observation ( k H / k D = 2.23), which indicates that reaction is initiated by THF radical but not by triazole radical …”

A chromatography-free one-pot, two-step synthesis of 1,2,4-thiadiazoles from primary amides via thiolation and oxidative dimerization under solvent-free conditions: a greener approach

“…The one-pot, two-step synthesis emerges as a potent and efficient strategy in contemporary organic chemistry, facilitating the streamlined assembly of complex molecules. 41 This innovative approach involves executing two separate chemical transformations consecutively within a single reaction vessel, eliminating the necessity for intermediate purification and isolation steps. 42 The advantage of this method lies in its ability to enhance reaction efficiency, reduce waste production, and enhance overall yields.…”