Facile Synthesis of new 3,5‐Dispiro Substituted Piperidine Analogs via Microwave‐Assisted One Pot Multicomponent Reaction

Chidurala, Praveen; Jetti, Venkateshwarlu; Meshram, Jyotsna S.

doi:10.1002/jhet.2424

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…An eco‐friendly procedure was reported to obtain 3,5‐dispirosubstituted piperidines from formaldehyde, 2‐thiobarbituric acid and aromatic amines in the presence of 1 equiv. of p ‐toluenesulfonic acid ( p ‐TSA) . Conventional heating of reactants afforded the product in 72% yield in 5 h whereas microwave irradiation resulted the product in 94% within 4 minutes (Scheme ).…”

Section: Classificationmentioning

confidence: 99%

Recent Advances in Microwave Assisted Multicomponent Reactions

et al. 2020

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Microwave (MW) assisted multicomponent reactions (MCRs) provide facile and expeditious procedures for the synthesis of several diversely functionalised molecules. Significant enhancement in selectivity, purity and reproducibility is offered by this process. Shorter reaction times as well as higher product yield are attained efficiently using MW assisted MCRs. The present review focuses on the developments in this field covering literature from 2013–2019 and the topic is categorised based on the final products obtained.

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Section: Classificationmentioning

confidence: 99%

Recent Advances in Microwave Assisted Multicomponent Reactions

et al. 2020

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“…Among the dynamic and emerging synthetic tools widely used in organic synthesis (OS) and medicinal chemistry, microwave irradiation (MWI) [54] reactions are considered as efficient, fast, and green chemistry procedures [55][56][57][58][59]. This technique has several advantages over classical stepby-step synthetic routes (linear or convergent) not only from atom-economy and eco-friendly perspective but also by the operational simplicity of these procedures that offer a variety of carbon-hetero atom bonds formation [60,61].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation

Treuer

De-la-Torre

Gutiérrez

2017

Journal of Chemistry

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Given the broad spectrum of biological uses of heteroaryl-acrylonitrile derivatives, it is necessary to find simple methods to synthesize and diversify this family of compounds. We report a stereoselective synthesis of a series of new (E)-2-(1H-indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles ( a-i) obtained from 3-(cyanoacetyl)indole and heteroaryl-aldehydes under microwaveassisted Knoevenagel reaction at 300 W of potency and 100 ∘ C. The desired derivatives ( a-i) were obtained with variable yields (30-94%) and time reactions (8-90 min). All the heteroaryl-acrylonitriles were characterized by physicoanalytical techniques such IR, 1 H, 13 C NMR, and electrospray mass spectrometry.

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