Facile synthesis of noncytotoxic PEGylated dendrimer encapsulated silver sulfide quantum dots for NIR-II biological imaging

Awasthi, Pragati; An, Xinyi; Xiang, Jiajia; Kalva, Nagendra; Shen, Youqing; Li, Chunyan

doi:10.1039/c9nr10918h

Cited by 53 publications

(41 citation statements)

References 37 publications

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“…These cells were then intravenously administered into a mouse and followed by NIR-II emission over 24 h. The fluorescence signal initially appeared in the liver but redistributed across the whole body over the 24-h period (Figure 6, Panel 1a). In contrast, when the same dose of PEG-PATU Ag 2 S QDs (14.78 mg mL À1 Ag 2 S) was administered in healthy controls, the emission remained confined within the liver throughout the experiment (Figure 6, Panel 1b), suggesting that the in vivo behavior of the cancer cells could be imaged using this technique (Awasthi et al, 2020).…”

Section: Non-specific Targetingmentioning

confidence: 99%

“…When applied via intravenous injection into a mouse (injected dose = 200 mg Ag 2 S) the vascular system of the mouse could be visualized through the NIR-II emission. This yielded high spatial resolution images (femoral artery diameter of 377 mm observed) in ''real time'' (Awasthi et al, 2020).…”

Section: Non-specific Targetingmentioning

confidence: 99%

“…This imaging modality is of great benefit for diagnosis, with preclinical applications for tumor identification and brain injury being demonstrated (Li et al, 2020). It has also been shown to be applicable to single-cell tracking (Awasthi et al, 2020) for studying the immune system and circulating tumor cells and has also been applied to fluorescence-guided surgery (Tian et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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NIR-quantum dots in biomedical imaging and their future

et al. 2021

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Fluorescence imaging has gathered interest over the recent years for its real-time response and high sensitivity. Developing probes for this modality has proven to be a challenge. Quantum dots (QDs) are colloidal nanoparticles that possess unique optical and electronic properties due to quantum confinement effects, whose excellent optical properties make them ideal for fluorescence imaging of biological systems. By selectively controlling the synthetic methodologies it is possible to obtain QDs that emit in the first (650-950 nm) and second (1000-1400 nm) near infra-red (NIR) windows, allowing for superior imaging properties. Despite the excellent optical properties and biocompatibility shown by some NIR QDs, there are still some challenges to overcome to enable there use in clinical applications. In this review, we discuss the latest advances in the application of NIR QDs in preclinical settings, together with the synthetic approaches and material developments that make NIR QDs promising for future biomedical applications.

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Section: Non-specific Targetingmentioning

confidence: 99%

Section: Non-specific Targetingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NIR-quantum dots in biomedical imaging and their future

et al. 2021

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“…For instance, Ag 2 S quantum dot, a NIR‐II (1,000–1,700 nm) imaging probe, was in situ formed in the core of a PEGylated polythiourea dendrimer (PATU) by initial strong affinity of abundant branching thiourea moieties to silver ions and subsequent reaction with sodium sulfide. The formed PEG‐PATU Ag 2 S quantum dots exhibited negligible cytotoxicity against A549 cancer cells (Awasthi et al, 2020). The synthesis of metallic NPs by reduction of metal ions that accumulated in dendrimers is a multielectron transfer reaction.…”

Section: Design Strategies For Dendritic Nano‐scale Systems For Cancementioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

173

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

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“…Not all of the diseases can express endogenous molecules with NIR-II absorption or emission; the development of exogenous agents with effective responsiveness to NIR-II light is of great importance for NIR-II phototheranostics. Currently developed agents for bioimaging and therapy in NIR-II window are mainly focused on inorganic nanomaterials (eg, quantum dots, 19,20 rare-earth nanoparticles, 21,22 and metallic nanoparticles [23][24][25][26] ), small S C H E M E 1 Schematic illustration of organic semiconducting nanomaterials-assisted phototheranostics in the second nearinfrared biological window molecule dyes (SMDs), [27][28][29] and organic semiconducting nanomaterials (OSNs). [30][31][32] For such kind of inorganic nanomaterials, the potential biotoxicity resulting from heavy metal ions and metabolic issues should be considered further.…”

Section: Introductionmentioning

confidence: 99%

Organic semiconducting nanomaterials‐assisted phototheranostics in near‐infrared‐II biological window

Yin

Lü

Fan

et al. 2020

VIEW

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Phototheranostics conducted in the near-infrared-II (NIR-II) biological window exhibits high superiorities relative to that conducted in the first near-infrared (NIR-I) window due to higher penetration depth, higher signal-to-noise ratio of imaging, and improved maximum permissible exposure. Currently, most existing agents developed for NIR-II phototheranostics are limited to inorganic nanoparticles and small-molecule dyes, which suffer from the issues of longterm biotoxicity and poor photostability, respectively. Organic semiconducting nanomaterials (OSNs) constructed from π-conjugated organic semiconducting polymers or oligomers have unique advantages including high photostability, flexible optical features, and good biocompatibility due to the totally organic and biologically inert constituents. These advantages make OSNs more promising for in vivo phototheranostics. We here make a brief review about recent progress of OSNs-assisted phototheranostics conducted in the NIR-II biological window. NIR-II fluorescence imaging and photoacoustic imaging are mainly reviewed as diagnostic modalities to guide various treatments. Besides, multimodal phototheranostics using OSNs in NIR-II window is also described. At last, the challenges and outlook for OSNs-assisted NIR-II phototheranostics are discussed. K E Y W O R D S cancer therapy, fluorescence imaging, organic semiconducting nanoparticle, photoacoustic imaging, second near-infrared window This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Facile synthesis of noncytotoxic PEGylated dendrimer encapsulated silver sulfide quantum dots for NIR-II biological imaging

Abstract: The water-soluble PEG-PATU Ag2S QDs have been successfully prepared by one-pot method, which display the favorable NIR-II fluorescence property for in vivo bioimaging.

Cited by 53 publications

References 37 publications

NIR-quantum dots in biomedical imaging and their future

NIR-quantum dots in biomedical imaging and their future

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Organic semiconducting nanomaterials‐assisted phototheranostics in near‐infrared‐II biological window

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