Facile synthesis of novel heterocyclic compounds based on pyridine moiety with pharmaceutical activities

Abstract

A novel run of fused heterocyclic derivatives containing pyridine moieties has been disclosed by allowing 2‐amino‐4‐phenyl‐6‐(phenyl amino)pyridine‐3,5‐dicarbonitrile 1 to undergo annulation reactions with different reagents. Most of synthesized compounds have moderate to strong antitumor activity against HePG‐2 and MCF‐7. Moreover, MOE 2014.09 software was used to run the computational studies to support the biological activity results. The assigned structures for all the newly prepared derivatives were ascertained on the basis of elemental analyses and spectral data.

Synthesis of Four Pentacyclic Triterpene–Sialylglycopeptide Conjugates and Their Affinity Assays with Hemagglutinin

“…These studies are meaningful supplements to heterocyclic compounds related to natural product synthesis, structural analysis, and biological activity research. Heterocyclic compounds not only have biological activity [ 41 , 42 ], but also make outstanding contributions in the field of catalytic reactions [ 43 ] and as natural product extractants [ 44 , 45 ]. In our previous work, SGP was hydrolyzed to obtain the glycan portion (SCT-Asn).…”

3D‐pharmacophore study molecular docking and synthesis of pyrido[2,3‐d]pyrimidine‐4(1H) dione derivatives with in vitro potential anticancer and antioxidant activities

“…In continuation of our program aiming to synthesize polyfunctional substituted heterocyclic compounds of potential biological activity, [ 3,4,8,17,18,23–29 ] the synthesis of poly‐functionalized 7‐amino‐5‐(4‐methoxyphenyl)‐2,4‐dioxo‐1,2,3,4‐tetrahydropyrido[2,3‐ d ]pyrimidine‐6‐carbonitrile ( 1a ) and 2‐amino‐4‐(4‐methoxyphenyl)‐5‐oxo‐5 H ‐dipyrido[1,2‐a:3′,2′‐ e ]pyrimidine‐3‐carbonitrile ( 1b ) was achieved via one‐pot multicomponent reactions of the barbituric acid and/or 3 H ‐pyrido [1,2‐ a ]pyrimidine‐2,4‐dione, [ 26 ] anisaldehyde, ammonium acetate and malononitrile or three‐component reactions of barbituric acid and/or 3 H ‐pyrido[1,2‐ a ]pyrimidine‐2,4‐dione, arylidine of malononitrile and ammonium acetate, under fusion at 150°C (Scheme 1).…”

“…[ 5,6 ] Polysubstituted‐pyridines possess remarkable biological and pharmacological activities and could also be used as‐agrochemicals such as herbicides and corrosion agent. [ 7,8 ] The molecules containing pyridine moiety are used as nonlinear visual materials, [ 9 ] electrical materials [ 10 ] and chelating agents in metal ligand chemistry. [ 11 ] It also worthy to mention that, 2‐amino‐3‐cyanopyridines in particular are known as‐IKK‐β‐inhibitors.…”

“…[ 11 ] It also worthy to mention that, 2‐amino‐3‐cyanopyridines in particular are known as‐IKK‐β‐inhibitors. [ 12 ] Furthermore, they have been identified to possess multiple biological activities such as anti‐microbial, anti‐bacterial, anti‐fungal, anti‐tumor, [ 8,13–18 ] anti‐viral, [ 19 ] anti‐inflammatory, [ 20 ] over and above anti‐hypertensive properties. [ 21 ] Besides, they have been utilized as important‐and useful intermediates and scaffolds in construction of a variety of heterocyclic products.…”

Zinc‐Catalysed Multi‐Component Reactions: An Overview

“…MCRs are thus truly ideal and environmentally benign systems where the desired product formation could be achieved only in one synthetic operation. These reactions could achieve quantitative yields with minimal work and high atom economy and could also synthesise diversity of products by changing the substrate moieties …”