Facile synthesis of pyrazolo[1,5-a]pyridopyrazin-one via Smiles rearrangement or direct cyclization

Xiao, Youxin; Zhang, Zhicheng; Chen, Yinbo; Shao, Xusheng; Li, Zhong; Xu, Xiaoyong

doi:10.1016/j.tet.2015.01.059

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Synthesis Of Pyrazolo[15‐a] Pyrazine Starting By Pyrazole Ring1

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Cited by 6 publications

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“…Pyrazolo[1,5‐ a ] pyridopyrazinone derivatives 95–97 were prepared by Smiles rearrangement or direct cyclization under mild conditions of 3‐bromo‐1‐(3‐chloro (bromo)pyridin‐2‐yl)‐ 1H ‐pyrazole‐5‐carboxamide 94 (Scheme ) .…”

Section: Synthesis Of Pyrazolo[15‐a] Pyrazine Starting By Pyrazole Ringmentioning

confidence: 99%

A Concise Review on the Synthesis and Reactions of Pyrazolopyrazine Heterocycles

ul‐Malik

Zaki

El‐Dean

et al. 2018

Journal of Heterocyclic Chem

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The pyrazolopyrazine ring system is a very interesting class of heterocyclic compounds that were considered as important scaffolds of many efficacious biologically active agents that show anticancer with low toxicity, antioxidant, anticonvulsant, antiparasitic, anti‐inflammatory, antiviral, antibacterial, antifungal, and analgesic activities. This review throws light on the detailed synthetic approaches for the synthesis and reactions of pyrazolopyrazine moiety. This follow up may encourage the chemists to generate new routes possessing pyrazolopyrazine nucleus with high efficacy.

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Section: Synthesis Of Pyrazolo[15‐a] Pyrazine Starting By Pyrazole Ringmentioning

confidence: 99%