Facile Synthesis of Substituted Quinazolin‐4‐(3H)‐ones Using Low‐Valence Titanium Reagent

Abstract

A short and facile synthesis of a series of 3-aryl quinazolin-4-(3H)-ones was accomplished in good yields via the intermolecular reductive coupling reaction of N-aryl-2-nitrobenzamide and triethyl orthoformate promoted by TiCl 4 /Zn.

Palladium-Catalyzed Cyclocarbonylation of o-Iodoanilines with Imidoyl Chlorides to Produce Quinazolin-4(3H)-ones

“…A few examples of transition metal-catalyzed routes to quinazolin-4( 3H )-ones have appeared in the literature, including the use of PdCl 2 (PPh 3 ) 2 and SnCl 2 catalysis . Quinazolin-4( 3H )-ones were also synthesized employing dicobalt octacarbonyl, ruthenium or platinum complexes, and titanium reagents as catalysts. One of us has developed a palladium-catalyzed reaction of o -iodoanilines with heterocumulenes to afford quinazolin-4( 3H )-ones derivatives …”