Facile synthesis of superparamagnetic nickel-doped iron oxide nanoparticles as high-performance T₁ contrast agents for magnetic resonance imaging

Abstract

Small-sized iron oxide nanoparticles (IONPs) are excellent alternative to clinical gadolinium-based contrast agents (GBCAs) in T1-weighted magnetic resonance imaging (MRI) due to their biosafety. However, the relaxation efficiency and contrast...

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

“…Different Biomedical Applications of Doped-IONPs. Doped-IONPs have diverse applications in various fields of biomedicine�for instance, in MRI, 78,79 visualization and diagnostics, 80 cancer therapy with magnetic hyperthermia, 81 photodynamic therapy, 82 development of biosensors, 83 environmental remedies, 31 and tissue engineering 84,85 -(Figure 2). Recently, experimental biomedical imaging field has gotten more focused on the fabrication of novel contrast agents with multimodal and versatile features of doped-IONPs.…”

“…Doped-IONPs have diverse applications in various fields of biomedicinefor instance, in MRI, , visualization and diagnostics, cancer therapy with magnetic hyperthermia, photodynamic therapy, development of biosensors, environmental remedies, and tissue engineering , ­(Figure ). Recently, experimental biomedical imaging field has gotten more focused on the fabrication of novel contrast agents with multimodal and versatile features of doped-IONPs. , In a standard MRI system, doped-IONPs can be employed at low concentrations as suitable negative contrast agents. ,− Additionally, doped-IONPs are ideal for cell labeling as perspective contrast agents.…”

Cubic Zinc-Doped Iron Oxide Nanoparticles with Poly(Ethylene Glycol) or Sodium Citrate Surface Coatings for Tumor Imaging

“…3 Iron oxide nanoparticles (IONPs) with high biocompatibility, ease of functionalization, and special magnetic property have been developed as transversal (T 2 ) relaxation MRI contrast agents to increase the signal difference between normal and lesion tissues. 4 Ferumoxytol, formed by 7 nm inorganic core of IONPs and 1.7 nm hydrophilic carboxymethyl-dextran, has been approved by the U.S. Food and Drug Administration to be a MRI contrast agent in 2009. 5 However, it works as an iron supplement instead of a T 2 MRI contrast agent nowadays owing to its relatively low T 2 contrast and undesirable behavior in vivo.…”

“…Although many innovative research studies targeted at strategies to have higher relaxivity and lower dose of Gadolinium (Gd) and manganese (Mn) have been studied a lot, people remain concerned about the retention and deposition of heavy metals in important organs such as kidney and brain, which can lead to fatal nephrogenic systemic fibrosis (NSF) and severe Alzheimer’s disease (AD) . Iron oxide nanoparticles (IONPs) with high biocompatibility, ease of functionalization, and special magnetic property have been developed as transversal ( T 2 ) relaxation MRI contrast agents to increase the signal difference between normal and lesion tissues . Ferumoxytol, formed by 7 nm inorganic core of IONPs and 1.7 nm hydrophilic carboxymethyl-dextran, has been approved by the U.S. Food and Drug Administration to be a MRI contrast agent in 2009 .…”

Direct large-scale synthesis of water-soluble and biocompatible upconversion nanoparticles for in vivo imaging

“…[26][27][28] In general, various synthesis techniques are employed to fabricate nanoparticles with controlled stoichiometry, crystal structure, and morphology. [29][30][31][32][33] Among these techniques, the thermal decomposition is particularly prominent due to its ability to precisely regulate the stoichiometric content, phase, size, and morphology of UCNPs. The synthesis process is typically involving the utilization of appropriate long-chain ligands in high boiling organic solvents to ensure high crystallinity and homogeneous shape.…”