Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery

Harvey, Sean; Ng, David Y. W.; Szelwicka, Jolanta; Hueske, Lisa; Veith, Lothar; Raabe, Marco; Lieberwirth, Ingo; Fytas, George; Wunderlich, Katrin; Weil, Tanja

doi:10.1116/1.5042640

Cited by 22 publications

(16 citation statements)

References 41 publications

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“…Based on the acrylic properties of thymolphthalein, the as‐prepared cytosensors could also afford a visible sensitive smartphone‐enabled cytosensing of cancer cells. In order to improve the stability of PDA NPs in various biological media, polyethylene glycol (PEG)‐grafted PDA NPs with an average size of 40 nm were prepared by Harvey et al Moreover, these amines‐terminated PEG–PDA NPs could be further functionalized, enabling their use in various biomedical applications. However, PEG‐grated NPs were reported to have biodegradation and immunogenicity problems .…”

Section: Colloidal Pda Particlesmentioning

confidence: 99%

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

Tran

Batul

Bhave

et al. 2019

Biotechnology Journal

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Since the first time mussel‐inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA‐based materials for therapeutic purposes. A description of the diverse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.

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Section: Colloidal Pda Particlesmentioning

confidence: 99%

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

Tran

Batul

Bhave

et al. 2019

Biotechnology Journal

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“…In particular, amine-terminated PEG3000 (PEG3000(NH 2 ) 2 ) reacted with polydopamine intermediates to form very small, crosslinked PDA-PEG nanoparticles with less than 50 nm in size. The formed PDA-PEG nanoparticles revealed efficient cellular uptake and high cytocompatibility thus rendering them attractive candidates for cell imaging or for drug delivery applications [24]. In a third example, anisotropic brush polymers with a protein backbone and polymer chains as side chains were discussed.…”

Section: Morning Session: Particle Characterization and Interactionsmentioning

confidence: 99%

LOEWE Workshop Particle Characterization in Medicine and Biology

2018

Pharm Front

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The workshop "Particle Characterization in Medicine and Biology" jointly organized by the LOEWE research center for Translational Medicine and Pharmacology and Malvern Panalytical Ltd. was held at the University Hospital, Goethe University in Frankfurt/Main on September 20 th 2018. Speakers from academia and industry gave insights into particle manufacture and characterization in various environments. Further, the implications for drug delivery and clinical translation of micro and nanotherapeutics were discussed.

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“…PDA nanoparticles (NPs), as a drug carrier, possess sustained drug release ability and excellent antioxidant activity due to the nanosized effects [ 5 – 7 ]. Additionally, the amine groups of PDA can help chemicals feasibly conjugate on the surface of PDA NPs [ 8 ]. Therefore, PDA NPs is an ideal drug carrier for drug delivery in hydrogel.…”

Section: Introductionmentioning

confidence: 99%

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

Zhang

et al. 2021

J Nanobiotechnol

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Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. Graphic Abstract

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Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery

Cited by 22 publications

References 41 publications

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

LOEWE Workshop Particle Characterization in Medicine and Biology

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

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