Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography

Song, Zhihua; Li, Shenghong; Guan, Yafeng; Wang, Shuo; Wang, Yinghao; Yang, Gangqiang; Zhang, Xiaochen; Li, Jinhua; Song, Wenhao; Zhou, Chuanming; Chen, Lingxin

doi:10.1016/j.chroma.2019.460659

Cited by 12 publications

(4 citation statements)

References 33 publications

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“…In this study, the MIPs/SiO 2 stationary phases were synthesized according to the below steps. Firstly, the bare silica microspheres were activated by the aqueous solution with 15% (w/w%) nitric acid, similar to my previous study [40]. Secondly, 2 g of activated silica spheres were added to 100 mL of anhydrous toluene with 5% of γ‐MPS (v/v); after 24 h stirring at 110°C, abundant propenyl was bounded on the surface of activated silica spheres using γ‐MPS as the silylating‐reagent.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and evaluation of ginsenosides imprinted polymer‐based chromatographic stationary phase

Xue

Zhang

et al. 2023

J of Separation Science

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The molecular imprinting technique has aroused great interest in preparing novel stationary phases, and the resulting materials named molecularly imprinted polymers coated silica packing materials exhibit good performance in separating diverse analytes based on their good characteristics (including high selectivity, simple synthesis, and good chemical stability). To date, monotemplate is commonly used in synthesizing molecularly imprinted polymersbased stationary phases. The resulting materials always own the disadvantages of low column efficiency and restricted analytes, and the price of ginsenosides with high purity was very high. In this study, to overcome the weaknesses of molecularly imprinted polymers-based stationary phases mentioned above, the multi-templates (total saponins of folium ginseng) strategy was used to prepare ginsenosides imprinted polymer-based stationary phase. The resulting ginsenosides imprinted polymer-coated silica stationary phase has a good spherical shape and suitable pore structures. Additionally, the total saponins of folium ginseng were cheaper than other kinds of ginsenosides. Moreover, the ginsenosides imprinted polymer-coated silica stationary phase-packed column performed well in the separation of ginsenosides, nucleosides, and sulfonamides. The ginsenosides imprinted polymer-coated silica stationary phase possesses good reproducibility, repeatability, and stability for seven days. Therefore, a multitemplates strategy for synthesizing the ginsenosides imprinted polymer-coated silica stationary phase is considered in the future. K E Y W O R D Schromatographic properties, molecular imprinting, polar pharmaceuticals, stationary phases, templates Article Related Abbreviations: EtOH, ethanol; HAC, acetic acid; MeOH, methanol; MIPs/SiO 2 , molecularly imprinted polymers coated silica; NIP/SiO 2 , non-imprinted polymer-modified silica microspheres; Sil-PEI/CDs, polyethyleneimine-functionalized carbon dots fabricated silica microbeads; XPS, X-ray photoelectron spectroscopy; γ-MPS, 3-(trimethoxysilyl)propyl methacrylate.

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Section: Methodsmentioning

confidence: 99%

Synthesis and evaluation of ginsenosides imprinted polymer‐based chromatographic stationary phase

Xue

Zhang

et al. 2023

J of Separation Science

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“…Similar to our previous work [22] , ZrO 2 /SiO 2 mesoporous microspheres were prepared as follows. Silica microspheres (5 g) were immersed in an aqueous solution of 0.1 M NaOH and stirred for half an hour.…”

Section: Preparation Of Zro 2 /Sio 2 Materialsmentioning

confidence: 99%

Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography

Song

Lü

et al. 2021

Journal of Chromatography A

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“…Hence, this study would provide a better understanding of their effects. The current study aims to develop, quantify, and validate posaconazole and cold-pressed hemp seed oil with its major constituent linoleic acid as shown in Figure c for a dual drug analytical method and its validation through reverse-phase high-performance liquid chromatography (RP-HPLC) …”

Section: Introductionmentioning

confidence: 99%

“…The current study aims to develop, quantify, and validate posaconazole and cold-pressed hemp seed oil with its major constituent linoleic acid as shown in Figure 1c 26 for a dual drug analytical method and its validation through reverse-phase high-performance liquid chromatography (RP-HPLC). 27 ■ MATERIALS AND METHODS Materials. Posaconazole was purchased from TCI Chemicals and the extracted hemp seed oil was obtained as a gift sample from Kumaokhand AIH Pvt., Ltd. Transcutol HP, PLGA, Tween 80, Precirol ATO 5, and poloxamer 188 were purchased from Sigma-Aldrich.…”

Section: ■ Introductionmentioning

confidence: 99%

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

et al. 2023

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The present study involves the development of a reverse-phase HPLC method employing the quality-by-design methodology for the estimation of posaconazole and hemp seed oil simultaneously in nanomicelles formulation. The successful separation of posaconazole and hemp seed oil was achieved together, and this is the first study to develop and quantify posaconazole and hemp seed oil nanomicelles with linoleic acid as the internal standard and developed a dual drug analytical method employing a quality-by-design approach. The study was performed on a Shimadzu Prominence-I LC-2030C 3D Plus HPLC system with a PDA detector and the Shim-pack Solar C8 column (250 mm × 4.6 mm × 5 μm) for analysis with a mobile phase ratio of methanol:water (80:20% v/v) maintaining the flow rate of 1.0 mL/min. The final wavelength was selected as 240 nm and the elution of hemp seed oil and posaconazole was obtained at 2.7 and 4.6 min, respectively, with a maximum run time of 8.0 min. Box Behnken design was employed to optimize the method, keeping the retention time, peak area, and theoretical plates as dependent variables, while the mobile phase composition, flow rate, and wavelengths were chosen as independent variables. Parameters such as specificity, accuracy, robustness, linearity, sensitivity, precision, ruggedness, and forced degradation study were performed to validate the method. The calibration curves of posaconazole and hemp seed oil were determined to be linear throughout the range for concentration. The suggested approach can be effectively utilized for estimating the content of drugs from their nanoformulation and proved suitable for both in vivo and in vitro research.

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Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography

Cited by 12 publications

References 33 publications

Synthesis and evaluation of ginsenosides imprinted polymer‐based chromatographic stationary phase

Synthesis and evaluation of ginsenosides imprinted polymer‐based chromatographic stationary phase

Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

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