Facile Synthesis of ZnMn₂O₄@rGO Microspheres for Ultrasensitive Electrochemical Detection of Hydrogen Peroxide from Human Breast Cancer Cells

Abstract

Mixed transition-metal oxides have witnessed increasing attention in catalysts and electrocatalysts. Herein, reduced graphene oxide-wrapped ZnMn2O4 microspheres (ZnMn2O4@rGO) were facilely synthesized through the solvothermal technique. The microstructure and morphology of ZnMn2O4@rGO microspheres were analyzed under Raman, X-ray photoelectron, X-ray diffraction, and energy-dispersive spectroscopies and scanning electron microscopy. The synthesized ZnMn2O4@rGO was employed as an excellent electrocatalyst for the reduction of hydrogen peroxide (H2O2). The ZnMn2O4@rGO-modified glassy carbon electrode (ZnMn2O4@rGO/GCE) exhibited a linear detection to H2O2 in a wide concentration range of 0.03–6000 μM with a detection limit of 0.012 μM. The biosensor was evaluated to determine H2O2 secreted by human breast cancer cells (MCF-7), indicating its promising applications in physiology and diagnosis.

Three-dimensional graphene encapsulated Ag–ZnFe2O4flower-like nanocomposites with enhanced photocatalytic degradation of enrofloxacin

“…Obviously, it can be seen that the intensity of C O and C–O are lower than C–C and C C, which indicates that oxygen-containing groups in GO has been reduced by high temperature heat treatment. 38 A schematic diagram of the heat treatment process is depicted in Fig. 3B .…”

“…4E , which indicates that oxygencontaining groups in GO has been reduced by high temperature heat treatment. 38 A schematic diagram of the heat treatment process is depicted in Fig. 3B.…”

Detection Technologies for Reactive Oxygen Species: Fluorescence and Electrochemical Methods and Their Applications

“…The difficulties associated with the use of biological sensing molecules have motivated researchers to use inorganic materials with mimicking enzymatic properties for H 2 O 2 detection. Some of those materials are silver NPs (AgNPs) [167][168][169][170], AuNPs [171][172][173][174], platinum NPs (Pt-NPs) [175,176], ZnO and ZnMn 2 O 4 [177,178], Ag and Au on ZnO nanoflowers [179], MnO 2 and Mn 3 O 4 [180,181], Co 3 O 4 [182,183], Co 9 S 8 hollow spheres [184], Cu 3 P nanowires [185], and lanthanide coordination polymer NPs [186].…”

Aptamer Embedded Arch-Cruciform DNA Assemblies on 2-D VS2 Scaffolds for Sensitive Detection of Breast Cancer Cells

“…It is noteworthy that breast cancer cells can endanger the lives of patients through proliferation and metastasis over a short time. Early diagnosis and treatment can be helpful to better understand the patients' condition, and make appropriate treatment plan according to the degree of disease, which is very important to improve the survival rate of breast cancer [4][5][6].…”