To further improve university students’ English comprehensive quality and knowledge level, a kind of information analysis and evaluation system based on the English course was put forward and designed. The construction of the informatization learning environment was explored from the perspective of ESP theory, combining with the existing problems of English informatization teaching in universities. It aimed at promoting the transformation and development of the targeting of English teaching, the application of the curriculum system, the specialization of the teaching content, and the multidimensional evaluation mechanism. The results showed that the application of ESP teaching theory in the construction of an informatization learning environment could provide the system and resource guarantee for the innovative development of the English teaching model and further optimize the English teaching method. Through a semester of The Foundation of University Information Technology MOOC study and practice in the practical operation of the evaluation system, the pass rate of each college was over 80%. And 91% of the students scored more than 60 in the final exam and 35% of the students scored more than 90.