Facilitation of electrical brain self-stimulation behavior by abused solvents

Bespalov, Anton; Sukhotina, I. A.; Medvedev, Ivan O.; Malyshkin, A.; Belozertseva, Irina; Balster, Robert L.; Zvartau, Edwin

doi:10.1016/s0091-3057(03)00071-6

Cited by 25 publications

(13 citation statements)

References 23 publications

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“…Other drugs acting at GABA receptors have a more varied profile of effects. For example, ethanol typically produces a modest but significant facilitation of ICSS, as do some abused solvents like toluene (Kornetsky et al, 1988;Bespalov et al, 1999;Bespalov et al, 2003;Chan et al, 2012;Fish ICSS in Abuse Potential Testing et al, 2010;Tracy et al, 2014) (Fig. 13D).…”

Section: Gabaergic Drugsmentioning

confidence: 98%

Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

2014

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Section: Gabaergic Drugsmentioning

confidence: 98%

Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

2014

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“…Toluene, cyclohexane, and benzene are each self-administered by rodents (Bespalov et al, 2003), and additional small organic compounds in petrol are likely responsible for similar effects.…”

Section: Introductionmentioning

confidence: 99%

How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission

Sulzer

2011

Neuron

511

430

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The fundamental principle that unites addictive drugs appears to be that each enhances synaptic dopamine by means that dissociate it from normal behavioral control, so that they act to reinforce their own acquisition. This occurs via the modulation of synaptic mechanisms involved in learning, including enhanced excitation or disinhibition of dopamine neuron activity, blockade of dopamine reuptake, and altering the state of the presynaptic terminal to enhance evoked over basal transmission. Amphetamines offer an exception to such modulation in that they combine multiple effects to produce non-exocytic stimulation-independent release of neurotransmitter via reverse transport independent from normal presynaptic function. Questions on the molecular actions of addictive drugs, prominently including the actions of alcohol and solvents, remain unresolved, but their ability to co-opt normal presynaptic functions helps to explain why treatment for addiction has been challenging.

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“…Toluene has high potential for abuse and addiction in humans. In animal studies, toluene has been shown to facilitate brain reward function using the intracranial self-stimulation (ICSS) procedure in rats (Bespalov et al 2003) and mice (Chan et al 2012a; Tracy et al 2014). In addition to possessing abuse liability, toluene intoxication produces motor incoordination, mental confusion, delusions, and amnesia (Andersen et al 1983 ; Chouaniere et al 2002; Meulenbelt et al 1990; Saito and Wada 1993).…”

Section: Introductionmentioning

confidence: 99%

The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances

et al. 2015

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Toluene, a widely abused solvent with demonstrated addictive potential in humans, has been reported to negatively modulate N-methyl-D-aspartate receptors (NMDARs) and alter glutamatergic neurotransmission. The group II metabotropic glutamate receptor (mGluR) agonist LY379268 has been shown to regulate glutamate release transmission and NMDAR function and block toluene-induced locomotor hyperactivity. However, remaining unknown is whether group II mGluRs are involved in the toluene-induced reward-facilitating effect and other behavioral manifestations. The present study evaluated the effects of LY379268 on toluene-induced reward enhancement, motor incoordination, recognition memory impairment, and social interaction deficits. Our data demonstrated that LY379268 significantly reversed the toluene-induced lowering of intracranial self-stimulation (ICSS) thresholds and impairments in novel object recognition, rotarod performance, and social interaction with different potencies. These results indicate a negative modulatory role of group II mGluRs in acute toluene-induced reward-facilitating and behavioral effects and suggest that group II mGluR agonists may have therapeutic potential for toluene addiction and the prevention of toluene intoxication caused by occupational or intentional exposure.

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Facilitation of electrical brain self-stimulation behavior by abused solvents

Cited by 25 publications

References 23 publications

Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission

The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances

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