Facilitation of Neurotransmitter and Hormone Release by P2X Purinergic Receptors

Vavra, Vojtech; Bhattacharya, Anirban; Jindrichova, Marie; Zemková, Hana

doi:10.5772/36279

Cited by 1 publication

(1 citation statement)

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“…Actions of extracellular ATP through P2X and P2Y receptors in the brain range from the regulation of membrane potential and electrical activity to neurotransmitter and hormone release (reviewed by (Vavra et al, 2012)). This diversity may account for the fact that the purinergic system has been implicated in a variety of pathologic disorders including trauma, stroke, ischemia, neurodegenerative disorders, migraine, seizure disorders, and neuropsychiatric conditions (Burnstock, 2008).…”

Section: The Purinergic System: General Overviewmentioning

confidence: 99%

Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics

Ortiz

Ulrich

Zarate

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

105

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Uric acid and purines (such as adenosine) regulate mood, sleep, activity, appetite, cognition, memory, convulsive threshold, social interaction, drive, and impulsivity. A link between purinergic dysfunction and mood disorders was first proposed a century ago. Interestingly, a recent nationwide population-based study showed elevated risk of gout in subjects with bipolar disorder (BD), and a recent meta-analysis and systematic review of placebo-controlled trials of adjuvant purinergic modulators confirmed their benefits in bipolar mania. Uric acid may modulate energy and activity levels, with higher levels associated with higher energy and BD spectrum. Several recent genetic studies suggest that the purinergic system particularly the modulation of P1 and P2 receptor subtypes—plays a role in mood disorders, lending credence to this model. Nucleotide concentrations can be measured using brain spectroscopy, and ligands for in vivo positron emission tomography (PET) imaging of adenosine (P1) receptors have been developed, thus allowing potential target engagement studies. This review discusses the key role of the purinergic system in the pathophysiology of mood disorders. Focusing on this promising therapeutic target may lead to the development of therapies with antidepressant, mood stabilization, and cognitive effects.

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Section: The Purinergic System: General Overviewmentioning

confidence: 99%