Facing Anthelmintic Resistance in Goats

Paraud, Carine; Chartier, Christophe

doi:10.1007/978-3-319-71855-2_16

Cited by 11 publications

(11 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is also the first published report on the occurrence of anthelmintic resistance in Sudan. Although one might expect that under subsistence farming conditions, use of anthelmintics is less frequent than on commercial farms with high stock numbers and high density of animals, the finding of resistance in Sudan extends the reported presence of resistant H. contortus in many different poor tropical countries including several in Africa [18, 19] such as Ethiopia, Kenya, Mozambique, Tanzania and Uganda [20–24]. Indeed, recent data from questionnaires suggests only moderate treatment frequencies in the study area [11], which are probably not sufficient to explain widespread ABZ resistance, in particular since ivermectin was also used.…”

Section: Discussionmentioning

confidence: 82%

“…However, goats should be treated with a double dosage since they metabolise most anthelmintics much faster than sheep [14]. Therefore, it must be assumed that under-dosing is a widespread problem in the study areas and it is well known that this can lead to rapid selection of resistance [18, 28]. If the FECRT was performed using the double dosage of 10 mg/kg bw, the observed FECRs slightly increased by 0–26% depending on the trial type, study day and the chosen control data.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of strongyle nematode infections and first report of benzimidazole resistance in Haemonchus contortus in goats in South Darfur State, Sudan

et al. 2019

View full text Add to dashboard Cite

Background Since pastoralists in South Darfur, Sudan, had complained about lack of albendazole (ABZ) efficacy to control nematodes in goats, the frequency of infection with gastrointestinal helminths was studied before in vivo faecal egg count reduction tests (FECRT) were conducted using ABZ orally either at the dose recommended for sheep, 5 mg/kg body weight (bw) or at 10 mg/kg bw. Experiments included goats naturally infected with gastrointestinal nematodes or experimentally infected with local Haemonchus contortus isolates. Three study areas (Nyala, Beleil and Kass) were visited in autumn or winter. Results Out of 478 screened goats, 82.4% were infected with gastrointestinal helminths and 82% were shedding eggs of strongyle nematodes with 90% of the strongyle larvae representing Haemonchus spp. A FECRT using naturally infected goats ( n = 225: 71 untreated, 104 and 50 treated with 5 and 10 mg ABZ/kg bw, respectively) detected reduced ABZ efficacy in Nyala and Kass. Paired and unpaired FECRT calculations detected reductions of 72–92% with samples taken at 8 days post treatment with 5 mg ABZ/kg bw and of 85–94% with 10 mg ABZ/kg bw. The FECRT based on day 14 post treatment samples showed reductions of 69–77% with 5 mg/kg and of 75–87% with 10 mg ABZ/kg bw. In Beleil, ABZ efficacy was 95%. In the egg hatch test EC 50 values for Nyala and Kass ranged from 0.12–0.24 μg thiabendazole/ml, corresponding to benzimidazole resistant phenotypes. Only Haemonchus spp. larvae were present after treatments in coprocultures. When the efficacy was evaluated experimentally using isolates of H. contortus from Nyala and Kass, the 5 mg ABZ/kg dose revealed reductions of 76–78% on day 8 and of 62–70% on day 14 with the unpaired method. Using 10 mg ABZ/kg, the FECR was still only 77–82%. Conclusions Both, in vivo and in vitro methods detected resistant H. contortus populations in goats from South Darfur State. The time point 14 days post treatment was more sensitive for detection of ABZ resistance than 8 days post treatment. This is the first report on the occurrence of anthelmintic resistance in Sudan confirming that anthelmintic resistance selection is occurring in African subsistence farming systems. Electronic supplementary material The online version of this article (10.1186/s12917-019-1937-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Epidemiology of strongyle nematode infections and first report of benzimidazole resistance in Haemonchus contortus in goats in South Darfur State, Sudan

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Several studies attempted to identify feed resources capable to affect the GIN biology beyond their nutritional properties. The identification of plants affecting GIN could contribute to addressing the overwhelming challenge of AH-resistant GIN populations affecting the efficacy of commonly available drugs [ 141 , 142 , 143 ], or even the newest molecules [ 144 , 145 ]. Furthermore, society is currently demanding limits on the use of xenobiotics that are polluting animal products and the environment.…”

Section: Building An Interdisciplinary Approach To Identify Plantsmentioning

confidence: 99%

Small Ruminant Production Based on Rangelands to Optimize Animal Nutrition and Health: Building an Interdisciplinary Approach to Evaluate Nutraceutical Plants

Torres-Fajardo

González-Pech

Sandoval-Castro

et al. 2020

Animals

View full text Add to dashboard Cite

The plant kingdom can influence the productivity and health of herbivores at different levels. However, demonstrating this process in a scientific manner entails substantial endeavors from different disciplines. In the present review, we will describe the features of a native vegetation system traditionally used by small ruminants and use its particularities to build an interdisciplinary approach to evaluate the nutraceutical properties of plants. Initially, we will establish the context of the low deciduous forest (LDF), considering some botanical and nutritional aspects, as well as the presence of plant secondary compounds (PSC) and gastrointestinal nematodes (GIN). Furthermore, we will focus on coevolutionary aspects that undoubtedly shaped the plants–nutrients–PSC–GIN–herbivore relationship. In addition, the concept of nutraceutical will be discussed to provide clarity and aspects to be considered for their evaluation. Then, ethological, agronomical, nutritional, PSC, parasitological and animal species issues are deepened placing emphasis on methodological approaches. Special focus is given to condensed tannins, as they are the fourth largest group of PSCs and the most studied in livestock sciences. Validation of the nutraceutical properties of plants from native vegetation systems should be seen as a process derived from many scientific disciplines that feed into each other in a cyclic manner.

show abstract

“…AR, however, has been less documented in goat herds than sheep flocks. Local reports or nationwide surveys for cases of resistance in goat GI nematodes to benzimidazoles (BZs), macrocyclic lactones (MLs), and levamisole (LEV) have been reported from the majority of European countries [ 10 ], but the prevalence and level of AR vary amongst the countries. Resistance in goat GI nematodes to BZs is widespread (≥80% prevalence) in Denmark [ 11 ] and Slovakia [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms

et al. 2021

View full text Add to dashboard Cite

Background Strongylid nematode infections may negatively affect both animal health and welfare, with deleterious consequences for livestock productivity. Many farmers in recent decades have relied on anthelmintics as the sole strategy of control, but the intensive use of these chemotherapeutics has led to the development of anthelmintic resistance (AR). Knowledge of both the efficacy of anthelmintics and factors promoting AR are essential to effectively control nematode infections, but no information on these topics for goats in the Czech Republic (CR) is available. This survey aimed to determine the occurrence of AR at Czech goat farms and to identify risk factors for the development of AR. A total of 24 herds of dairy goats across the CR were evaluated using in vitro tests for detecting AR, and a questionnaire survey was carried out to evaluate factors associated with AR. Results Resistance against benzimidazoles was confirmed at 18 (75%) farms, and the level of resistance was high in four (22%) of the affected herds based on the egg hatch test. Ivermectin-resistant nematodes were detected in 13 (54%) herds using the larval development test; Teladorsagia/Trichostrongylus and Haemonchus were the predominant types of resistant larvae. Eight (62%) of the affected herds were evaluated as highly resistant to ivermectin. Eleven (46%) of the herds were resistant to both benzimidazoles and ivermectin. This report is the first on dual AR in the CR. A univariate logistic regression analysis indicated that a high stocking rate and farmer inexperience were significantly associated with ivermectin and benzimidazole resistance, respectively. Conclusions The results of our survey suggest that AR is widespread amongst herds of dairy goats in the CR, likely due to inappropriate practices of pasture and health management. AR may be an issue for expanding dairy-goat production in the CR in the near future unless both veterinary practitioners and farmers widely adopt strategies to prevent the development of AR.

show abstract

Facing Anthelmintic Resistance in Goats

Cited by 11 publications

References 152 publications

Epidemiology of strongyle nematode infections and first report of benzimidazole resistance in Haemonchus contortus in goats in South Darfur State, Sudan

Epidemiology of strongyle nematode infections and first report of benzimidazole resistance in Haemonchus contortus in goats in South Darfur State, Sudan

Small Ruminant Production Based on Rangelands to Optimize Animal Nutrition and Health: Building an Interdisciplinary Approach to Evaluate Nutraceutical Plants

Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms

Contact Info

Product

Resources

About