Facteurs environnementaux impliqués dans la maladie d’Alzheimer. Le mercure dentaire, probable déterminant majeur

Grosman, M.; Picot, A.

doi:10.1016/j.mlong.2009.06.001

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…This potent neurotoxicant accumulates in different compartments of the developing brain, including the hippocampus, cerebral cortex, cerebellum and retina (Grosman et al, 2010). Inorganic mercury disrupts glutamate transport and glutamine synthetase (GS) activity (Grosman et al, 2009). However, the Hg-EAA batch has a significantly lower learning time during the 3rd and 4th days compared to the Hg batch, with a non-significant decrease during the first two days of learning.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic effect of the aqueous extract of Pimpinella anisum on the behavior of Wistar rats exposed to mercury

et al. 2021

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DOI: 10.15835/nsb13110878 The purpose of this study was to evaluate the prophylactic effect of Pimpinella anisum (green anis) on neurobehavioral status following mercury chloride intoxication during the developmental period. For this purpose, rats exposed to 100 mg/L of HgCl2 during the gestation and lactation period. A group of rats was treated with the anis extract for 15 days before becoming intoxicated with mercury. In contrast, one group was orally administered aqueous anis extract for 15 days after intoxication. The forced swimming test, the open field test and the Morris pool respectively recorded an increase in immobility time, a decrease in the number of cross-cells (p <0.001), (p <0.05) and an increase in latency (p <0.01), (p <0.001), (p <0.001) and decreased time spent in the target frame during the probe test (p <0.01) and increased latency in the visible test (p <0.01) in HgCl2 - exposed rats compared to control rats. However, preventive and curative aniseed-based treatment reduced the rate of depression, increased locomotor activity and improved learning performance. In conclusion, the aqueous extract of Pimpinella anisum could have a corrective effect on some neurological disorders caused by mercury.

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Section: Discussionmentioning

confidence: 99%

Prophylactic effect of the aqueous extract of Pimpinella anisum on the behavior of Wistar rats exposed to mercury

et al. 2021

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“…A rather new development is the insight that AD might be a form of diabetes, where neurons become insulin resistant (de la Monte and Wands 2005; de la Monte and Wands 2008; Grosman and Picot 2009). Of note, insulin also increases the production of amyloid beta and triggers proinflammatory processes, while the hippocampus expresses many insulin receptors, testifying to the importance of insulin also in the brain (Marks, Porte et al 1990).…”

Section: Carbohydrates and Diet Restrictionmentioning

confidence: 99%

Towards Primary Prevention of Alzheimers Disease

Walach¹,

Loef²

2012

AJAD

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The incidence of Alzheimer's disease is predicted to rise as life expectation grows across populations. The cause of the disease is unknown, and very likely multifactorial. Pharmacological attempts at curing, stopping or modifying it have, by and large, been unsuccessful, and no breakthrough is in sight. However, a lot of elements that seem to contribute to the disease as risk factors have been identified, mainly from epidemiological and basic research studies. Many of these are amenable to lifestyle modification. We describe what we see as important elements here, along with the supporting evidence. We propose that the following elements would be crucial pillars for a primary prevention program: a) the avoidance and removal of toxins b) a healthy diet c) culture of consciousness with an emphasis on constructive use of cognitive capacities and information load, along with the practice of some mindfulness based exercise on a regular basis to implement stress control d) physical exercise and an active lifestyle e) supportive social relationships. While all these elements are being researched in single fashion or in various combinations, to our knowledge there is no program that combines them all. While most lifestyle intervention studies have used a rather strict formula, we advocate individual adaptation and counselling to find ways of implementing necessary changes in ways that are sustainable. These would then need to be followed up by implementation studies and studies on long term effects.

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Alzheimer’s Dementia and Lifestyle: Towards a Primary Prevention

Walach

Loef

2013

Social Neuroscience and Public Health

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Facteurs environnementaux impliqués dans la maladie d’Alzheimer. Le mercure dentaire, probable déterminant majeur

Cited by 5 publications

References 44 publications

Prophylactic effect of the aqueous extract of Pimpinella anisum on the behavior of Wistar rats exposed to mercury

Prophylactic effect of the aqueous extract of Pimpinella anisum on the behavior of Wistar rats exposed to mercury

Towards Primary Prevention of Alzheimers Disease

Alzheimer’s Dementia and Lifestyle: Towards a Primary Prevention

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