Factor analysis for the adoption of nuclear technology in diagnosis and treatment of chronic diseases

Sato, Renato Cesar; Zouain, Desirée Moraes

doi:10.1590/s1679-45082012000100013

Cited by 8 publications

(10 citation statements)

References 2 publications

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“…Future studies thus have the challenge of refining the instruments used in innovation diffusion and/ or adoption studies (MacKenzie, Podsakoff & Podsakoff, 2011). Perhaps, we should expect more papers in the genre of Sato and Zouain (2012) geared toward instrument development and/ or refinement.…”

Section: Discussionmentioning

confidence: 99%

A call for Return to Rogers’ Innovation Diffusion Theory

Bakkabulindi¹

2014

Mak. J. High. Edu.

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This paper argues that Rogers' Innovation Diffusion Theory (IDT) is the original theory for guiding research on innovation diffusion and/ or adoption, from which the more recent theories have been derived. Hence, the paper suggests a framework based on the IDT, and derives 14 hypotheses for future research, basing on a review of recent literature. The framework divides the correlates of diffusion and/ or adoption of innovations into three categories: individual adopter characteristics, perceived innovation characteristics and social system or organizational characteristics. In terms of individual adopter characteristics, it is hypothesized that interaction with change agents, training and cosmopolitanism positively relate to the adoption of innovations, while age and income are negatively and positively related to the adoption of innovations respectively. Gender is related to the adoption of innovations in a way that males are more apt. Regarding perceived innovation characteristics, the perceived relative advantage, compatibility, user friendliness and 'observability' are postulated to be positively related to the adoption of innovations. On organizational characteristics, it is postulated that each of organizational readiness for change, culture, size and leader's change management style is positively related to the adoption of innovations. Gaps in the studies reviewed are highlighted.

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Section: Discussionmentioning

confidence: 99%

A call for Return to Rogers’ Innovation Diffusion Theory

Bakkabulindi¹

2014

Mak. J. High. Edu.

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“…Irradiation pertains to the process of distributing energy into space or matter using waves and particles (Repacholi, 2017;Li et al, 2019). Ionizing and non-ionizing irradiation have been extensively utilized in medicine, agriculture, food processing, national defense, and daily activities, and they have also negatively influenced human health (Sato and Zouain, 2012;Sutlief, 2015;Andrianov et al, 2015;von Neubeck et al, 2015). Ionizing irradiation includes X-ray and g-ray.…”

Section: Introductionmentioning

confidence: 99%

Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats

Wang

et al. 2020

Front. Pharmacol.

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The objective of this study was to investigate the regulation of X-ray irradiation and its effect on the activity and protein and mRNA expression levels of CYP1A2 and CYP2E1 in rats. Rats were randomly divided into 0 Gy (control), 1 Gy (low-dose irradiation), and 5 Gy (high-dose irradiation) groups. CYP1A2 and CYP2E1 activity was evaluated from changes in pharmacokinetic parameters of caffeine and chlorzoxazone, respectively. The plasma concentrations of the probe drugs were determined by high-performance liquid chromatography (HPLC). Enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR) tests were used to analyze the protein and mRNA expression levels of CYP1A2 and CYP2E1, respectively. The AUC 0-12 of caffeine was decreased by 1.7-and 2.5-fold, and the CL was increased by 1.8-and 2.6-fold in the 1 Gy and 5 Gy groups, respectively, compared to the 0 Gy group. The AUC 0-10 of chlorzoxazone was 1.4-and 1.8-fold lower, and the CL was 1.4-and 1.9-fold higher in the 1 Gy and 5 Gy groups, respectively, compared to the 0 Gy group. The metabolism of caffeine and chlorzoxazone increased under X-ray irradiation as CL levels increased and AUC levels decreased, suggesting that CYP1A2 and CYP2E1 activity is enhanced in rats after X-ray irradiation. Compared to that of the 0 Gy group, the protein expression level of CYP1A2 was measured as 28.3% and 38.9% higher in the 1 Gy and 5 Gy groups, respectively. The protein expression level of CYP2E1 was 48.4% higher in the 5 Gy group compared to the 0 Gy group, and there was no statistically significant difference between 0 Gy and 1 Gy. Compared to the 0 Gy group, the mRNA expression level of CYP1A2 was 200% and 856.3% higher in the 1 Gy and 5 Gy group, respectively, whereas the mRNA expression level of CYP2E1 was 89.0% and 192.3% higher in the 1 Gy and 5 Gy groups, respectively. This study reveals significant changes in the activity and protein and mRNA expression levels of CYP1A2 and CYP2E1 in rats after exposure to X-ray irradiation. AnimalsSprague Dawley SPF rats (200 ± 20 g, certificate No. 2007-001) of both sexes were provided by the laboratory animal center at Xi'an Jiaotong University Medical College, China. They were adapted for a week at 23 ± 2°C with a constant humidity level of 55% ± 5% under a cycle of 12 h of dark conditions and given ad libitum Li et al. X-Ray Irradiation and CYP1A2 and CYP2E1 Frontiers in Pharmacology | www.frontiersin.org January 2020 | Volume 10 | Article 1575 2

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“…Irradiation is a process of emitting and spreading energy into space or matter in forms of wave and particle, and it can be divided into ionizing irradiation and nonionizing irradiation . Although the irradiation has been intensively applied into the fields of medicine, resources, military, food processing, national defense, and living standard , it also brings a certain degree of impairment to human health . Researchers have discovered a series of physiological variation and pathological changes under irradiation, which can affect drugs’ absorption, distribution, metabolism, and excretion processes in body .…”

Section: Introductionmentioning

confidence: 99%

Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats

Qiao

Wang

Xin

et al. 2019

Fundamemntal Clinical Pharma

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Concurrent chemoradiation with irinotecan hydrochloride (CPT‐11) is accepted for cancer treatment. However, the effects of X‐ray irradiation on chemotherapeutics in the plasma remain unclear. We evaluated the pharmacokinetics of CPT‐11 in rats after exposure to X‐ray irradiation and examined the changes of protein and mRNA expression of CES1 and CYP3A1. The X‐ray irradiation with 1 Gy and 5 Gy was delivered to the whole body of rats. CPT‐11 at 30 and 60 mg/kg, respectively, was intravenously infused 24 h after irradiation. CPT‐11 was determined by RP‐HPLC in plasma. ELISA and PCR were used to analyze the protein and mRNA expression of CES1 and CYP3A1, respectively. Compared with control rats, the X‐ray irradiation decreased the AUC of CPT‐11 (30 mg/kg) by 15.6% at 1 Gy and 39.0% at 5 Gy and increased the CL by 60.0% at 5 Gy. The X‐ray irradiation could also decrease the AUC of CPT‐11 (60 mg/kg) and increase the CL. In addition, the protein and mRNA expression of CES1 and CYP3A1 were increased significantly in rats after irradiation. This study found significant changes in the pharmacokinetics of CPT‐11 in rats after exposure to X‐ray irradiation, and they might be due to significant increases in the expressions of CYP3A1 and CES1. The pharmacokinetics of CPT‐11 should be rechecked, and the optimal CPT‐11 dose should be reevaluated during concurrent chemoradiation therapy.

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Factor analysis for the adoption of nuclear technology in diagnosis and treatment of chronic diseases

Cited by 8 publications

References 2 publications

A call for Return to Rogers’ Innovation Diffusion Theory

A call for Return to Rogers’ Innovation Diffusion Theory

Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats

Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats

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