Factor de necrosis tumoral como marcador de inflamación precoz en fumadores sanos

Piña, J.M. Díez; Fernández-Aceñero, María Jesús; Alonso, María J.; Lobato, Salvador Díaz; Alises, Sagrario Mayoralas; Rodríguez, Esteban Pérez; Álvarez, Dolores Álvaro; Horcajada, A. Flórez; Rojo, Ricardo

doi:10.1016/j.medcli.2011.11.032

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…70 Tobacco exposure is also a risk factor for HCC. Tobacco smoking is associated with increased plasma levels of inflammatory cytokines such as TNF-alpha and IL-1beta 71,72 and markers of oxidative stress. 72,73 These mediators can contribute to necro-inflammatory changes in the liver, which in turn may promote the development of HCC.…”

Section: Pathophysiology Past and Recent Issuesmentioning

confidence: 99%

“…Tobacco smoking is associated with increased plasma levels of inflammatory cytokines such as TNF-alpha and IL-1beta 71,72 and markers of oxidative stress. 72,73 These mediators can contribute to necro-inflammatory changes in the liver, which in turn may promote the development of HCC. 74 In brief, prolonged exposure to alcohol and tobacco is expected to promote the development of HCC in an additive and/or synergistic manner.…”

Section: Pathophysiology Past and Recent Issuesmentioning

confidence: 99%

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Concise Review on the Frequency, Major Risk Factors and Surveillance of Hepatocellular Carcinoma (Hcc) in Β-Thalassemias: Past, Present and Future Perspectives

Sanctis¹,

Soliman

Daar

et al. 2020

Mediterr J Hematol Infect Dis

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Due to the recent alarming increase in the incidence of hepatocellular carcinoma (HCC) in thalassemias, the aim of the present report is to review briefly the frequency, the major risk factors and the surveillance of HCC in β-thalassemias. Over the past 33 years, 153 cases of HCC were reported in patients with thalassemia, mainly in Italy, and Greece. Among HCV-infected patients additional factors promoting development of HCC, included: advanced age, male sex, chronic hepatitis B (CHB) coinfection, and iron overload. For early diagnosis of HCC sequential ultrasound screening is recommended especially for thalassemia patients with chronic hepatitis C (CHC), that coincide with (one or more) additional risk factors for HCC. Here we report also the preliminary data of thalassemic patients, above the age of 30 years, followed in 13 different centers. The total number of enrolled patients was 1,313 (males: 612 and 701 females). The prevalence of HCC in thalassemia major patients [characterized by transfusion-dependency (TDT)] and thalassemia intermedia [characterized by nontransfusion dependency (NTDT)] was 1.68 % and 1.98 % ,respectively The lowest age at diagnosis was 36 years in TDT and 47 years in NTDT patients.We hope that our review can be used to develop more refined and prospective analyses of HCC magnitude and risk in patients with thalassemia, and to define specific international guidelines to support clinicians for an early diagnosis and treatment of HCC in thalassemic patients.

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Section: Pathophysiology Past and Recent Issuesmentioning

confidence: 99%

Section: Pathophysiology Past and Recent Issuesmentioning

confidence: 99%

Concise Review on the Frequency, Major Risk Factors and Surveillance of Hepatocellular Carcinoma (Hcc) in Β-Thalassemias: Past, Present and Future Perspectives

Sanctis¹,

Soliman

Daar

et al. 2020

Mediterr J Hematol Infect Dis

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“…Taken together, tobacco exposure may contribute to the initiation and promotion of HCC due the presence of mutagenic and carcinogenic compounds as well as by causing oxidative stress due to generation of ROS and depletion of endogenous antioxidants. Tobacco smoking is associated with increased plasma levels of inflammatory cytokines such as TNF-alpha and IL-1beta (Barbieri et al, 2011; Diez Pina et al, 2012) and markers of oxidative stress (Valenca et al, 2008; Barbieri et al, 2011). These mediators can contribute to necro-inflammatory changes in the liver, which in turn may promote the development of HCC.…”

Section: Role Of Tobacco Exposure In Hccmentioning

confidence: 99%

Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma

et al. 2013

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The purpose of this report is to summarize the roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma (HCC). Chronic heavy alcohol exposure is a major risk factor for HCC, which is the most frequent type of liver cancer. Alcohol ingestion may initiate and or promote the development of HCC by: 1) acetaldehyde-DNA adduct formation; 2) cytochrome P4502E1-associated reactive oxygen species (ROS) generation, lipid peroxidation, p53 mutation, and conversion of pro-carcinogens to carcinogens; 3) iron accumulation that leads to ROS generation, lipid peroxidation, p53 mutation, and initiation of inflammatory cascade via nuclear factor-KappaB (NF-kB) activation; 4) glutathione depletion leading to oxidative stress; 5) s-adenosylmethionine (SAM) depletion and associated DNA hypomethylation of oncogenes ; 6) retinoic acid depletion and resultant hepatocyte proliferation via up-regulation of activator protein-1 (AP-1); 7) initiating an inflammatory cascade through increased transfer of endotoxin from intestine to liver, Kupffer cell activation via CD14/toll-like receptor-4 (TLR-4), oxidative stress, NF-kB or early growth response-1(Egr-1) activation, and generation of inflammatory cytokines and chemokines; 8) induction of liver fibrosis; and 9) decreasing the number and/or function of Natural Killer cells. Tobacco exposure is also a risk factor for HCC. It may contribute to the initiation and promotion of HCC due the presence of mutagenic and carcinogenic compounds as well as by causing oxidative stress due to generation of ROS and depletion of endogenous antioxidants. Simultaneous exposure to alcohol and tobacco is expected to promote the development of HCC in an additive and/or synergistic manner.

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Inflamación, tabaco y enfermedad pulmonar obstructiva crónica. Demasiadas preguntas y pocas respuestas

Miravitlles

2012

Medicina Clínica

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Factor de necrosis tumoral como marcador de inflamación precoz en fumadores sanos

Cited by 7 publications

References 31 publications

Concise Review on the Frequency, Major Risk Factors and Surveillance of Hepatocellular Carcinoma (Hcc) in Β-Thalassemias: Past, Present and Future Perspectives

Concise Review on the Frequency, Major Risk Factors and Surveillance of Hepatocellular Carcinoma (Hcc) in Β-Thalassemias: Past, Present and Future Perspectives

Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma

Inflamación, tabaco y enfermedad pulmonar obstructiva crónica. Demasiadas preguntas y pocas respuestas

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