Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques

Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells

“…FSAP decreased the level of apoptosis after serum starvation in VSMC ( Figure 10A) and this effect were completely reversed by pre-treatment of FSAP with aprotinin ( Figure 10B). FSAP expression was increased in unstable atherosclerotic plaques 44 in humans. In relation to the role of FSAP in apoptosis, FSAP would tend to promote the retention of VSMC within plaques and increase stability of the plaque, and thereby have a beneficial role on vascular pathophysiology.…”

“…Later the protease was characterized for its proteolytic actions on Factor VII and was therefore given the name FSAP 43 . FSAP is primarily expressed and secreted into the circulation by hepatocytes but is also expressed in monocytes and monocyte-derived macrophages 44 as well as by different lung cancer cell lines 45 . Studies on FSAP -/-mice and the linkage of single nucleotide polymorphisms (SNP) with diseases suggest that FSAP is a multifunctional protease with diverse pathophysiological functions.…”

Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome

“…12 More recently, various studies have supported the emerging role of FSAP in advanced atherosclerosis and cardiovascular diseases. [13][14][15][16][17] Next to hepatocytes, the major cellular source of intravascular FSAP is monocytes, the only blood cells capable of synthesizing FSAP in response to various inflammatory mediators such as cytokines and bacterial endotoxins. 13 FSAP expression is also enhanced by differentiation of human circulating monocytes into macrophages.…”

“…[13][14][15][16][17] Next to hepatocytes, the major cellular source of intravascular FSAP is monocytes, the only blood cells capable of synthesizing FSAP in response to various inflammatory mediators such as cytokines and bacterial endotoxins. 13 FSAP expression is also enhanced by differentiation of human circulating monocytes into macrophages. FSAP accumulates in unstable coronary atherosclerotic plaques, but is only minimally expressed in stable PARAHULEVA MS et al…”

Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid

“…8,9) It has been suggested that PHBP plays roles in the regulation of inflammation, 10) vascular function, 11) neointima formation, 12) liver fibrosis, 13) and atherosclerosis. 11,14) Therefore, a compound that regulates pro-PHBP activation might contribute to pharmacological control of the progression of these diseases.…”