Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid

Sekido, Chikako; Nishimura, Naoko; Takai, Masayuki; Hasumi, Keiji

doi:10.1271/bbb.100373

Cited by 10 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,[14][15][16] Most of these inhibitors have a polyphenol feature. In particular, potent inhibitors have plural catechol units, such as galloyl and caffeoyl groups.…”

mentioning

confidence: 99%

Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation

Yamamoto

Kitano

Hasumi

2011

Bioscience, Biotechnology, and Biochemistry

Self Cite

View full text Add to dashboard Cite

Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. Here we found that compounds with plural catechol groups conjugated with strong electron-withdrawing groups, such as tyrphostin AG 537 (IC(50)=18 nM), were potent inhibitors of pro-PHBP activation.

show abstract

“…10,[14][15][16] Most of these inhibitors have a polyphenol feature. In particular, potent inhibitors have plural catechol units, such as galloyl and caffeoyl groups.…”

mentioning

confidence: 99%

Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation

Yamamoto

Kitano

Hasumi

2011

Bioscience, Biotechnology, and Biochemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is known that inhibitory mechanism of PHBP by LA and CA is different. LA is a potent inhibitor of the protease of both autoactivation of the PHBP proenzyme and catalytic activity of the active enzyme (Yamamichi et al, 2010) and CA is a specific inhibitor of polyamine-induced pro-PHBP autoactivation (Sekido et al, 2010). Therefore, it may be possible that CA-enriched CE in the present study could not efficiently exert inhibitory activity because of the lack of the polyamine induced pro-PHBP autoactivation in the thyroid environment.…”

Section: Discussionmentioning

confidence: 84%

“…Because larger CICs were formed with CE-treatment in addition to SDM, there may be larger population of CICs consisting of two or more smaller foci in the SDM+CE group as compared with the SDM-alone group. Different from the pharmacological action at high doses, activation of PHBP is promoted by low concentration of LC in the serum (Sekido et al, 2010). On the other hand, effect of CE at low concentrations on the activity of PHBP is not known.…”

Section: Discussionmentioning

confidence: 91%

Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats

et al. 2012

Self Cite

View full text Add to dashboard Cite

Cochineal extracts (CE) is a coccid-derived natural food colorant containing carminic acid (CA) as an active ingredient that potentiates inhibition of tissue proteolysis mediated by activation of plasma hyaluronan-binding protein (PHBP). In our previous study, dietary administered CE (CA: 28.5% in CE) has shown to promote the macroscopic development of capsular invasive carcinomas (CICs) associated with up-regulation of angiogenesis-related genes in an intracapsular invasion model of experimental thyroid cancers using rats. However, the promoting effect of CE could not be confirmed histopathologically. The purpose of the present study was to confirm the promoting effect of CE through direct injections to animals on the development of CICs using this cancer invasion model. One week after initiation with N-bis(hydroxypropyl)nitrosamine, male F344/NSlc rats were administered CA-enriched CE (CA: 52.6% in CE) by intraperitoneal injections every other day (10 mg/kg body weight) during the promotion with 0.15% sulfadimethoxine in the drinking water for 8 weeks. The multiplicities of macroscopical CICs and the mean area of early capsular invasive foci estimated by Tenascin (TN)-C-immunoreactivity in the thyroid significantly increased with CE-treatment, while the number of TN-C-positive foci did not change with CE. Transcript level of Phbp and downstream genes unchanged; however, transcript level of angiogenesis-related genes, i.e, Vegfb and its transcription factor gene, Hif1a, those being downstream of phosphatase and tensin homolog (PTEN)/Akt signaling, up-regulated in the thyroid tissue with CE-administration. These results suggest that CE potentiates promotion activity by facilitating angiogenesis through activation of PTEN/Akt signaling without accompanying modification of PHBP-related proteolysis.

show abstract

“…This potential makes quinones interesting for the treatment of various diseases like cancer [17], inflammation [18], or antiaging purposes [9]. Unfortunately, these compounds are characterized by their low stability, making them very sensitive to light and heat.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Novel Bigel-Based 1,4-Naphthoquinones for Topical Application with Antioxidant Potential

et al. 2019

View full text Add to dashboard Cite

This is an author's version published in: http://oatao.univ-toulouse.fr/25602 Abstract Discovering new antioxidant agents and optimizing their processing is a necessity to treat skin diseases. The assessment of quality and antioxidant activity of topical formulations based on 5,8-dihydroxy-1,4-naphthoquinone (M1) and 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (M2) was carried out for the first time for this purpose. Stability studies including evaluation of pH, viscosity, microscopic observation, and microbiological quality were determined. M1 and M2 were examined for their antioxidant capacities after their incorporation into bigels. Obtained data suggested that BG-M1 and BG-M2 have a good quality, a natural pH of the skin (4.5-6.0), and no sign of microbial development. Sensory analysis was also performed, and no negative assessment of unpleasant bigel properties was found. M1 and M2 have shown antioxidant activity toward DPPH radical (data are expressed as IC 50 ), 19 × 10 −3 mg/mL for M1 and 35 × 10 −3 mg/mL for M2, respectively. After their formulations, they have maintained this ability, for BG-M1 = 3.0 and BG-M2 = 1.1 mg/mL. Also, they demonstrated interesting ABTS scavenging with 1.5 × 10 −3 and 2.5 × 10 −3 mg/mL for M1 and M2, respectively. They kept this potential after formulation, since, BG-M1 = 1.7 mg/mL and BG-M2 = 4.9 mg/mL. Likewise, pure molecules revealed notable β-carotene bleaching inhibition (0.3 and 0.1 mg/mL for M1 and M2, respectively), which was maintained after their formulation into bigels (2.9 and 10.3 mg/mL for BG-M1 and BG-M2, respectively). These developed bigels maintaining the antioxidant potential of M1 and M2 could be used as the provision of a barrier to protect skin.

show abstract

Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid

Cited by 10 publications

References 15 publications

Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation

Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation

Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats

Development and Characterization of Novel Bigel-Based 1,4-Naphthoquinones for Topical Application with Antioxidant Potential

Contact Info

Product

Resources

About