Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis

Dunné, Frederique M. van; Doggen, Carine J.M.; Heemskerk, Mattijs M.; Rosendaal, Frits R.; Helmerhorst, Frans M.

doi:10.1093/humrep/deh640

Cited by 29 publications

(15 citation statements)

References 23 publications

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“…Robertson et al [48] have called for larger epidemiological studies to justify the inclusion of routine screening for inherited thrombophilias in RSM clinics because of some conflicting reports [45,95] on the impact of inherited thrombophilia on RSM and other adverse pregnancy outcomes.…”

Section: Rsm Investigationsmentioning

confidence: 99%

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Diejomaoh¹

2014

Med Princ Pract

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Recurrent spontaneous miscarriage (RSM), affecting 1-2% of women of reproductive age seeking pregnancy, has been a clinical quagmire and a formidable challenge for the treating physician. There are many areas of controversy in the definition, aetiology, investigations and treatment of RSM. This review will address the many factors involved in the aetiology of RSM which is multifactorial in many patients, with antiphospholipid syndrome (APS) being the most recognized aetiological factor. There is no identifiable cause in about 40-60% of these patients, in which case the condition is classified as idiopathic or unexplained RSM. The RSM investigations are extensive and should be undertaken in dedicated, specialized, well-equipped clinics/centres where services are provided by trained specialists. The challenges faced by the treating physician are even more overwhelming regarding the decision of what should be the most appropriate therapy offered to patients with RSM. Our review will cover the diverse modalities of therapy available including the role of preimplantation genetic testing using recent microarray technology, such as single nucleotide polymorphism and comparative genomic hybridization, as well as preimplantation genetic diagnosis; the greatest emphasis will be on the treatment of APS, and there will be important comments on the management of patients presenting with idiopathic RSM. The controversial areas of the role of natural killer cells in RSM, the varied modalities in the management of idiopathic RSM and the need for better-planned studies will be covered as well.

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Section: Rsm Investigationsmentioning

confidence: 99%

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Diejomaoh¹

2014

Med Princ Pract

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“…The relationship between pregnancy loss and thrombophilia is a much-debated topic with well entrenched expert opinion on both sides and many studies reporting significant associations with pregnancy loss (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) and others no associations (13)(14)(15)(16)(17). The thrombophilic factor V Leiden (FVL) G1691A mutation has been found to be significantly associated with recurrent pregnancy loss (RPL, R3 consecutive pregnancy losses <20 weeks gestation) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

“…However, it is possible that by selecting only women without any previous thromboembolism, Dizon-Townson et al (16) truncated the cohort to FVL-carrying women who were less likely to have subsequent uterine spiral artery thrombosis during pregnancy. Van Dunne et al (17) recruited consecutive patients who had sustained a first venous thrombosis event and compared the first 115 female patients with FVL versus 230 age-matched female patients without FVL. They reported that FVL carriers had no difference in pregnancy loss rate; specifically, first-trimester pregnancy loss rate was lower in FVL carriers than in noncarriers.…”

mentioning

confidence: 99%

Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss

Glueck

Gogenini

Munjal

et al. 2008

Fertility and Sterility

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“…Some studies reported a decreased risk of miscarriage in women with inherited thrombophilia [57,58], whereas one study reported that multiple genetic thrombophilic mutations in either partner seem to increase the risk of miscarriage in a subsequent pregnancy [59]. Larger epidemiological studies are clearly needed to justify testing couples with RM for inherited thrombophilia in routine clinical practice [60].…”

Section: Thrombophiliamentioning

confidence: 99%

Early pregnancy failure: a review

Exalto

Christiansen

Farquharson

et al. 2006

Eur Clinics Obstet Gynaecol

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The European Society for Human Reproduction and Embryology's Special Interest Group Early Pregnancy recently published a revised terminology for the description of early pregnancy events as well as evidence-based guidelines for the investigation and medical treatment for patients with recurrent miscarriage (RM). This review, designed for clinicians working in the field of human reproduction, starts with the updated glossary of terms essential for an accurate assessment and documentation of clinical events. The revised terminology is summarized in this article. Many terms used in early pregnancy were old and had persisted before or since the introduction of ultrasound. Based on the data of recently published randomized controlled trials (RCTs) and meta-analysis, recommendations are provided for basic investigations of couples presenting with RM and for proposed therapies. The recommendations are likewise summarized in this article. A large number of therapies mentioned in the literature require more investigations under strict RCT conditions, whilst others are of no proven benefit or are associated with more harm than good.

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Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis

Cited by 29 publications

References 23 publications

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss

Early pregnancy failure: a review

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