Factor VIII levels in children with thrombosis

Kürekçi, Ahmet Emin; Gökçe, Hafize; Akar, Nejat

doi:10.1046/j.1442-200x.2003.01683.x

Cited by 28 publications

(29 citation statements)

References 24 publications

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“…The limitation of the present study and of other pediatric cohorts reported [3][4][5][6][7]13,29,41 is mainly attributable to the rarity of the disease. To obtain more reliable data in children with DVT, PTS, or recurrent DVT in comparative as well as prospective follow-up studies, larger cooperative international surveys are necessary to better address this topic.…”

Section: Discussionmentioning

confidence: 70%

Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome

Kreuz¹,

Stoll²,

Junker³

et al. 2006

ATVB

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Objective-To evaluate the role of factor (F) VIII in children with non-cancer related venous thrombosis (DVT), post-thrombotic syndrome (PTS) or recurrent DVT. Methods and Results-FVIII levels were measured in White patients and age-and gender-matched healthy controls.Heritability of factor VIII was estimated in 99 pedigrees by the variance component method implemented in SOLAR. Key Words: factor VIII and children Ⅲ body mass index Ⅲ venous thrombosis Ⅲ post-thrombotic syndrome Ⅲ recurrent thrombosis

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Section: Discussionmentioning

confidence: 70%

Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome

Kreuz¹,

Stoll²,

Junker³

et al. 2006

ATVB

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“…Further, it was reported that increased FVIII levels are an important risk factor for venous and arterial thrombosis [11,16]. Yürürer et al [17] showed a negative relationship between sEPCR and FVIII levels in a group of pediatric stroke patients.…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have shown that the coagulant activity of FVIII is increased as an acute phase reaction in thrombosis [8,9]. Elevated plasma levels of FVIII are associated with an increased risk of venous and arterial thrombosis [10,11]. Possible mechanisms thought to be associated with elevated FVIII are the enhancement of thrombin formation or the induction of acquired activated protein C resistance, but the molecular mechanisms that underlie elevated FVIII are still not clear.…”

Section: Introductionmentioning

confidence: 99%

The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants

Orhon¹,

Eğin²,

Ulukol³

et al. 2011

Turk J Hematol

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Objective: Both soluble endothelial protein C receptor (sEPCR) and factor VIII (FVIII) seem to be potential mediators in thrombotic and inflammatory states. The aim of the present study was to determine the relation between plasma sEPCR and FVIII levels in a group of healthy Turkish infants. Materials and Methods: The study population consisted of 50 healthy infants aged 6 months (Group 1, n=23) and 12 months (Group 2, n=27) having no acute or chronic infection and/or disease. sEPCR levels and FVIII levels were measured by ELISA and one stage factor assay method, respectively. Results: The sEPCR levels of the infants aged 6 months were found higher than those of the infants aged 12 months (p<0.001). There was a correlation between sEPCR and FVIII levels of the infants in Group 1 (6-month-old infants) (r=0.678, p<0.001). FVIII/sEPCR index was 0.73±0.3 and 1.0±0.5 in Group 1 and Group 2, respectively (p=0.027). A correlation between infant age and FVIII/sEPCR index was found (r=0.312, p=0.027). Conclusion: The FVIII/sEPCR index in healthy infants reflects the physiological condition of this population. The finding showing a positive relationship between sEPCR and FVIII levels suggests a possible interaction between these mediators in healthy infants aged six months. (Turk J Hematol 2011; 28: 27-32) Key words: Soluble endothelial protein C receptor (sEPCR), factor VIII, healthy infants, thrombosis

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“…High FVIII levels are known to be a risk factor for venous thrombosis and its recurrence in adults [11,12,13] and children [14, 15]. Recently, the association of high FVIII levels with PVT has been reported [16,17,18].…”

Section: Discussionmentioning

confidence: 99%

Portal Vein Thrombosis and High Factor VIII in Turner Syndrome

Zilz

Brenner²,

Elnecave³

2006

Horm Res Paediatr

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Backgrounds/Aims: Turner syndrome is not usually associated with thrombotic events. The aim of this study is to report 3 Turner syndrome patients with portal vein thrombosis and, in 2 of them, high factor VIII. These findings are compared to values in Turner syndrome patients without thrombosis and controls. Methods: In different years, 3 patients with Turner syndrome were initially seen at the Gastroenterology Clinic of Hospital de Clínicas de Porto Alegre, Brazil, for portal vein thrombosis. After the most common causes of portal vein thrombosis and thrombophilias had been excluded, the 2 surviving patients were studied for clotting factors VIII, IX and von Willebrand factor. The same factors were also assessed in 25 Turner syndrome patients without thrombosis and 25 normal girls. Results: One of the patients with portal vein thrombosis died before the study. In the 2 surviving patients, factors VIII and von Willebrand levels were >150 IU/dl, which is considered to be high. In Turner syndrome patients without thrombosis, the mean factor VIII level was 127.2 ± 41.1 IU/dl and for von Willebrand factor 101.2 ± 26.9 IU/dl, while in control girls these were 116.0 ± 27.6 and 94.28 ± 27.5 IU/dl, respectively. Factor VIII and von Willebrand factor were not different between these 2 groups. When non-O blood group Turner syndrome patients and normal girls were compared, the former had significantly higher levels of factor VIII. Conclusions: This is the first report on the unusual finding of portal thrombosis in patients with Turner syndrome in whom high levels of factor VIII and von Willebrand factor were found. Factor VIII is higher in the non-O blood group Turner syndrome patients without thrombosis when compared to normal girls.

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Factor VIII levels in children with thrombosis

Abstract: The data in the present study provide evidence that elevated plasma factor VIII levels are associated with increased risk of thrombosis in children: thus, plasma concentration of factor VIII should be measured in all children with TE.

Cited by 28 publications

References 24 publications

Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome

Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome

The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants

Portal Vein Thrombosis and High Factor VIII in Turner Syndrome

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