Factor VIII related antigen in the assessment of vasculitis.

Woolf, Anthony D.; Wakerley, G; Wallington, T. B.; Scott, D. G. I.; Dieppe, P.

doi:10.1136/ard.46.6.441

Cited by 95 publications

(27 citation statements)

References 36 publications

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“…Although both fibrinogen and vWF are acute phase response proteins, this would not necessarily preclude a pathogenetic role in diabetic microvascular disease, for the above reasons, and as an explanation for the increased levels this mechanism is inconsistent with previous observations, where plasma C-reactive protein and vWF were not related in diabetes [14], nor in the vasculitides [52]. Regarding fibrinogen, the interrelationships with lipid parameters in the current and previous studies have not been linked to a reactive state, although recent data do suggest an association between lipid vascular risk factors, fibrinogen and C-reactive protein [53].…”

Section: Discussioncontrasting

confidence: 57%

Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study

et al. 1997

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The pathogenic mechanisms underlying the development of microvascular complications in insulin-dependent diabetes mellitus (IDDM) remain obscure despite the fact that retinopathy develops in the majority [1][2][3], and nephropathy in around 30 % [3,4]. Although duration of diabetes and poor glycaemic control are established risk factors, they appear to account for only a proportion of an individual's risk [5]. We have recently demonstrated that, in subjects with retinopathy but not those without, mean urinary albumin excretion rate increases steeply when the mean diastolic blood pressure rises above 75 mmHg. It thus appears that members of a subgroup of diabetic subjects may have abnormal renal vulnerability Diabetologia (1997) Summary The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 European countries: the EURODIAB IDDM Complications study. The anticipated significant relationships between both plasma fibrinogen and plasma von Willebrand factor concentrations and age and glycaemic control, and between fibrinogen and body mass index, were noted. Fibrinogen, adjusted for age and glycated haemoglobin concentration, was also related to smoking habits and was higher in the quartiles with highest systolic and diastolic blood pressures. There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males. An inverse relationship between fibrinogen and high density lipoprotein cholesterol was also apparent in males. A prominent feature was a positive relationship between both fibrinogen and von Willebrand factor and albumin excretion rate (p < 0.001 and p < 0.003 respectively) in those with retinopathy but not in those without this complication. In view of previous observations on blood pressure and albuminuria in these subjects the findings are consistent with the hypothesis that microalbuminuria and increased plasma von Willebrand factor are due to endothelial cell perturbation in response to mildly raised blood pressure in subjects with retinopathy. Fibrinogen may also contribute to microvascular disease and its relationships to lipid vascular risk factors suggest a possible pathogenic role in arterial disease in diabetes. [Diabetologia (1997) to mildly raised blood pressure and that retinopathy is a close correlate of this risk [6].von Willebrand factor (vWF) is synthesised by vascular endothelial cells and megakaryocytes and an increased concentration in plasma can serve as a marker of endothelial cell damage [7][8][9]. Such an increase is a feature of diabetic nephropathy [10]. Recent studies in small numbers of subjects with IDDM suggest that vWF is a sensitive marker of incipient nephropathy and that a r...

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Section: Discussioncontrasting

confidence: 57%

Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study

et al. 1997

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“…The circulating plasma pool is derived mainly from endothelial cells [22]. It is an acute-phase reactant and is elevated in infectious diseases [23], numerous inflammatory and vasculitic diseases, after surgery, in pregnancy, and after exercise [22,[24][25][26]. Levels are also high in atherosclerosis [24] and essential hypertension [27] in the absence of an acute-phase reaction.…”

Section: Discussionmentioning

confidence: 99%

Soluble cell adhesion molecules and von Willebrand factor in children with Kawasaki disease

Nash¹,

Shah²,

Dillon³

1995

Clinical and Experimental Immunology

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SUMMARYFifty-nine children with acute Kawasaki disease (KD), a childhood vasculitis.. were compared with 35 children with fever due to infection and 48 healthy childreti. Levels of soluble E-selectin (sEselectin), soluble intercellular adhesion molecule-1 (s!CAM-I), and soluble vascular cell adhesion molecule-1 (sVCAM-I) in ihe healthy children were double Ihose found in adults. Al! Ihree soluble cell adhesion molecules and von Willebrand factor (vWF) were higher in the children wilh KD than in the healthy children, but only sE-selectin, a marker for activated endothelial cells, and slCAM-1 were higher than in the febrile children. The high levels of vWF in KD appear to reflect the prominent acute-phase reaction. This information can help us to understand further the complex interactions between cytokines. circulating inflammatory cells and the vascular endothelium. and may lead to aew tlwrapeutic avenues in KD and other inflammatory diseases and vasculitides.

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“…The vWF is synthesized by endothelial cells (E C) and megakaryocytes, and then stored in EC (WeibelPalade bodies) and platelets (α-granules) [4][5][6]. It is known that increased expression of vWF in blood vessel endothelial cells is associated with endothelial damage [7,8], blood vessel maturation [9] and regression [10]. It has been reported that the regression process in atretic follicles coincides with an increased expression of vWF [11,12].…”

mentioning

confidence: 99%

Immunolocalization of von Willebrand Factor and Vascular Endothelial Growth Factor during Follicular Atresia in the Swamp Buffalo Ovary

Feranil

Isobe

Nakao

2005

Journal of Reproduction and Development

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Abstract. The aim of this study was to investigate the distribution pattern of von Willebrand factor (vWF) and vascular endothelial growth factor (VEGF) in the healthy antral and atretic follicles of Philippine swamp buffaloes (SB) in comparison with Holstein-Friesian cows (HF). Paraffin sections of healthy follicles and atretic follicles at various stages were immunostained with vWF antibody and VEGF antibody. The density of vWF-positive capillary vessels in the theca interna significantly increased as atresia progressed in SB, whereas the density significantly decreased in late atretic follicles compared with advanced ones in HF. On the other hand, the area of vWF-positive capillary vessels in the theca interna significantly increased as atresia progressed in both SB and HF. Immunoreactions of VEGF in the granulosa cells (in all follicle types) were observed in both SB and HF. In the granulosa layer, a reduction in the VEGF immunoreaction was noted as follicles progressed from healthy to advanced atretic follicles in both animals. Granulosa cells (in both SB and HF) showed a higher immunopositive staining than theca cells. In the theca interna, VEGF immunostaining diminished as follicles progressed to the late atretic follicles in both animals. These results indicate that during atresia, changes of vWF expression are the opposite of VEGF expression in SB. Both vWF and VEGF are suggested to be associated with follicular atresia in SB.

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Factor VIII related antigen in the assessment of vasculitis.

Cited by 95 publications

References 36 publications

Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study

Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study

Soluble cell adhesion molecules and von Willebrand factor in children with Kawasaki disease

Immunolocalization of von Willebrand Factor and Vascular Endothelial Growth Factor during Follicular Atresia in the Swamp Buffalo Ovary

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