Factor XIIIa-containing cells and fibrosis in oral and maxillofacial lesions: An immunohistochemical study

Toida, Makoto; Watanabe, Fumio; Tsai, Chung‐Shao; Okutomi, Tadashi; Tatematsu, Norichika; Oka, Nobumitsu

doi:10.1016/0030-4220(89)90214-4

Cited by 21 publications

(10 citation statements)

References 26 publications

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“…In several immunohistochemical studies, it has been reported that the FXIIIa-positive connective tissue cells increase in number in lesions associated with fibrosis, such as liver cirrhosis (20), granulation tissue of gastric ulcer (35), systemic nodular panniculitis (40) and fibrous stroma of several types of salivary gland tun}ors (39,41). In our previous studies, we indicated findings suggesting that these FXIIIa-positive cells proliferate and differentiate prior to marked fibrosis in various oral lesions (42,43). Also in a recent study by Penneys (30), further findings supporting such a concept have been reported in various dermal reparative lesions.…”

Section: Resultssupporting

confidence: 63%

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Factor XIIIa-positive cells in the human pulmonary tissues: An immunohistochemical study.

Toida

Okumura

Handa

et al. 1990

Acta Histochem. Cytochem

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Section: Resultssupporting

confidence: 63%

“…It has been described in the previous study (42) that the results of staining for FXIIIa obtained with the ethanol-acetic acid-fixed and paraffin-embedded specimens are nearly comparable to those obtained with the frozen specimens and better than those obtained with the formalin-fixed and paraffin-embedded specimens.…”

Section: Methodssupporting

confidence: 54%

Factor XIIIa-positive cells in the human pulmonary tissues: An immunohistochemical study.

Toida

Okumura

Handa

et al. 1990

Acta Histochem. Cytochem

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“…Data about the dermal dendrocyte's presence in different dermatopathologic states and conclusions about its presumptive role are often conflicting (Nemes and Thomazy 1988;Cerio et al 1988;Nemeth and Penneys 1989;Nickoloff and Griffiths 1989a, b;Cerio et al 1989b;Toida et al 1989;Penneys 1990;Cerio and Jones 1990a, b;Gray et al 1990Gray et al , 1991Penneys et al 1991;Regezi et al 1993;Gibran et al 1994a). Distinction of the dermal dendrocyte from fibroblasts, macrophages, Langerhans cells and other dendritic cells of the immune system has been based on immunocytochemical localization of cell markers.…”

Section: Discussionmentioning

confidence: 99%

“…Its presence in inflammatory dermatoses (e.g. psoriasis, eczema), Kaposi's sarcoma, dermatofibromas and acute burn wounds, but not in mature scars, keloids or fibroproliferative diseases (Nemes and Thomazy 1988;Cerio et al 1988;Nickoloff and Griffiths 1989a, b;Nemeth and Penneys 1989;Cerio et al 1989b;Toida et al 1989;Penneys 1990;Cerio and Jones 1990a, b;Gray etal. 1990;Gray etal.…”

Section: Introductionmentioning

confidence: 99%

Ontogeny and characterization of Factor XIIIa+ cells in developing human skin

1996

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Factor XIIIa (FXIIIa), a coagulation transglutaminase, is a cytoplasmic marker for dermal dendritic cells reported to be bone marrow-derived, phagocytic and antigen-presenting. In non-inflamed skin, these cells populate the papillary dermis in a perivascular distribution. They are increased in dermatoproliferative disorders and have been implicated as dermal stimulants for psoriatic hyperkeratosis. Since developing skin provides an example of dermal influence on the epidermis, we evaluated the presence of FXIIIa+ cells in human fetal skin to determine whether their location would suggest a role in morphogenetic events in the skin. Embryonic and fetal skin of progressive estimated gestational ages (EGA) was examined using immunocytochemistry with a polyclonal antibody to FXIIIa. At 6 weeks EGA, globular FXIIa+ cells were present in the hypodermis. By 7-8 weeks, a compact sub-epidermal network of fusiform FXIIIa+ cells was also evident. By 11-12 weeks, the sub-epidermal cellular network was no longer FXIIIa+, but discrete FXIIIa+ dendritic cells were present in the reticular dermis. With advancing gestational age, FXIIIa+ dendritic cells populated the papillary dermis in a perivascular distribution. This adult-like distribution persisted through 22 weeks EGA, the oldest specimen examined. Because FXIIIa+ cells were evident in embryonic skin before the onset of bone marrow hematopoietic function, the skin was double-labeled with the FXIIIa antibody and with monoclonal antibodies to CD45 (marker for bone marrow-derived cells), CD68 (marker for macrophages) and HLA-DR (class II major histocompatibility antigen). Most of the FXIIIa+ dendritic cells did not colocalize CD45, but were CD68+; some cells did react with the HLA-DR antibody. Notably, the FXIIIa+ cells of the sub-epidermal network in the 7 weeks EGA specimens did not react with the other antibodies. We conclude that FXIIIa+ cells are first present in embryonic hypodermis and sub-epidermal dermis and later they are distributed in the papillary dermis in a perivascular pattern. In embryonic skin FXIIIa+ cells are not exclusively dendritic. Our data support the idea that cells that express FXIIIa do not constitute a unique bone marrow-derived cell type, but that multiple cell types produce FXIIIa.

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“…Factor XIIIa-positive mononuclear cells have been identified in a number of tissues exhibiting elevated levels of fibrosis (17) and were particularly prominent in the morphea specimens examined in the present study.…”

Section: Discussionmentioning

confidence: 50%

Immunocytochemical Localization and Serologic Detection of Transforming Growth Factor β1

Higley¹,

Persichitte²,

Chu³

et al. 1994

Arthritis & Rheumatism

156

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Objective. To determine the presence of transforming growth factor β1 (TGFβ1) and inflammatory cell markers (HLA–DR and Factor XIIIa) and to compare these with the presence of type I procollagen, in clinically uninvolved and involved skin from patients with different subsets of systemic sclerosis (SSc), and to analyze circulating levels of TGFβ1 in SSc patients. Methods. TGFβ1, HLA‐DR, Factor XIIIa, and type I procollagen were detected in skin biopsy sections using a biotin–streptavidin–peroxidase system. Levels of circulating TGFβ1 were measured using a capture enzyme‐linked immunosorbent assay technique. Results. Patients with active diffuse cutaneous SSc (dcSSc) showed minimal TGFβ1 but significant type I procollagen staining in involved skin, while the clinically uninvolved skin of these patients showed moderate extracellular and intra‐epidermal TGFβ1 immunoreactivity. Patients with limited cutaneous SSc (IcSSc) showed elevated TGFβ1 staining in both involved and uninvolved skin, as well as procollagen staining. Significant TGFβ1 reactivity, HLA–DR and Factor XIIIa immunoreactivity, numerous inflammatory cells, and procollagen staining were seen in specimens from patients with morphea. Sequential biopsies suggested the presence of cytokine activity at the earliest stages of disease, which was not maintained with progression of sclerosis. Among the disease groups studied, elevated levels of circulating TGFβ1 were seen only in patients with morphea. Conclusion. The pattern of TGFβ1 staining in dermal sections from patients with dcSSc, IcSSc, and morphea suggests that this cytokine is important in the pathogenesis of scleroderma. Furthermore, the presence of TGFβ1 prior to the onset of fibrosis indicates an early involvement of this growth factor, possibly in the inflammatory stage of the disease.

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Factor XIIIa-containing cells and fibrosis in oral and maxillofacial lesions: An immunohistochemical study

Cited by 21 publications

References 26 publications

Factor XIIIa-positive cells in the human pulmonary tissues: An immunohistochemical study.

Factor XIIIa-positive cells in the human pulmonary tissues: An immunohistochemical study.

Ontogeny and characterization of Factor XIIIa+ cells in developing human skin

Immunocytochemical Localization and Serologic Detection of Transforming Growth Factor β1

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