Factores de riesgo asociados a recaída de enfermedad por reflujo gastroesofágico en pacientes de primer nivel de atención exitosamente tratados con inhibidor de la bomba de protones

López‐Colombo, Aurelio; Pacio-Quiterio, M.S.; Jesús-Mejenes, L.Y.; Rodríguez-Aguilar, J.E.G.; López-Guevara, M.; Montiel-Jarquín, Álvaro José; López-Alvarenga, Juan Carlos; Morales-Hernández, E.R.; Ortiz-Juárez, V.R.; Ávila-Jiménez, Laura

doi:10.1016/j.rgmx.2016.09.001

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…There was a negative association between coffee and GERD symptoms [ 23 , 24 ], while in another study, there was a role of coffee in increasing the GERD symptoms [ 29 ]. However, the coffee consumption is a risk factor for GERD relapsing after treatment with PPIs [ 30 ]. Giving the fact that many soft drinks are highly acidic, a change in the intra-esophageal PH may precipitate a GERD-like symptom, which may also increase the acid load in the stomach leading to increased probability of gastroesophageal reflux [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Gastroesophageal Reflux Disease in Saudi Arabia

et al. 2017

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BackgroundGastroesophageal reflux disease (GERD) is one of the most prevalent gastrointestinal tract diseases worldwide. GERD has an effect on the patients’ quality of life as well as the health care system that can be prevented by identifying its risk factors among the population. Hence, we applied this study to assess the GERD’s risk factors in Saudi Arabia.MethodsA cross-sectional study was designed to assess the GERD’s risk factors among the community of Saudi Arabia. The sample was collected randomly during the period from November to December 2016. Through a self-administered validated GERD questionnaire (GerdQ), GERD was diagnosed. Then, the GERD’s risk factors were assessed among all participants. The data were analyzed using Statistical Package for Social Sciences version 21.0; the Student’s t-test was used to assess the association of GERD and risk factors.ResultsA total of 2,043 subjects participated in the study. The characteristics and behaviors of participants statistically significant with GERD were positive family history (39.3%), obese (body mass index > 30 kg/m2) (39.4%), not performing weekly regular physical activities ≥ 30 min (31.1%) and smoking (39.3%). GERD was commonly noticed in participants on analgesics (38.4%), not taking fibers (37.4%), drinking tea (33.4%), eating greasy (31.2%) and fast food (32.7%), and these were statistically significant with GERD (P ≤ 0.05).ConclusionThe characteristics and behaviors associated with GERD in Saudi population are family history of GERD, obesity, sedentary lifestyle and smoking. Other common risk factors correlated with GERD are analgesics intake, no fibers intake, drinking tea, greasy and fast food intake.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Gastroesophageal Reflux Disease in Saudi Arabia

et al. 2017

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“…[19] Previous studies have indicated that the risk factors of GORD include sleep apnea, unhealthy diet, obesity, psychological factors, current smoking, causes of heart disease, drinking and diabetes. [20][21][22] However, GORD can be prevented, and changing the above risk factors through education can be an important prevention strategy for GORD. Although the guidelines recommend patient education, there are few previous studies on GORD patient education, and the results are contradictory.…”

Section: Discussionmentioning

confidence: 99%

Education could be a protective factor against gastro-oesophageal reflux disease: a Mendelian randomization study

Chen

Xie

Liang

et al. 2022

Preprint

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Background Patient education has been shown to be beneficial for a variety of diseases. Similarly, observational studies have shown that education contributes to the prevention and treatment of gastroesophageal reflux disease (GORD). However, this relationship is not supported by strong evidence. Methods We used publicly available genetic summary data from two large consortia, the Psychiatric Genomics Consortium, with data from 1,271 single-nucleotide polymorphisms (SNPs) closely associated with educational attainment (EA), and the UK Biobank, including 41 024 patients with GORD and 410 073 control cases. For Mendelian randomization (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum, and outlier test to retrieve summary data. Analyses were performed using the ‘Two Sample MR’ package in R. Results Our results showed that the potential causal relationship between education and lower risk of GORD was statistically significant (OR 0.979, 95% CI 0.975–0.984, P = 0.002). Similar results were obtained using the methods of weighted median and weighted mode. The sensitivity analysis is consistent with the causal explanation. Longer education tended to be associated with lower body mass index, lower risk of hypertension, lower risk of type 2 diabetes, less cigarettes per day and more alcoholic intake per week. Conclusions Our analysis shows that education may have a negative causal effect on GORD, which can be a protective factor for the prevention of GORD.

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“…The statistical power calculation was carried out to estimate the sample size for the superiority trial. According to our review of studies, relapse rates of patients with healed lesions have been reported to be 54% to 66.2% at 12 wk after drug therapy was withdrawn[2,20,21], so our estimation of the average relapse rate for the placebo group was 60%. Also, cured RE patients who received an additional maintenance treatment had a relapse rate of 10% at 12 wk and 28.4% to 30% at 32 wk after drug therapy was stopped[1,22].…”

Section: Methodsmentioning

confidence: 99%

“…Frequent relapses are common with RE, resulting in significant physical pain and financial burden on patients. Studies on the treatment of RE are scarce[1,2]. The first-line treatment for RE is administration of proton pump inhibitors (PPIs)[3], which are the most commonly prescribed drugs worldwide.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial

Sun

Wang

Sun

et al. 2019

WJG

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BACKGROUND Reflux esophagitis (RE) is a common digestive disorder, and its frequent recurrences cause significant physical pain and are financially burdensome to patients. However, studies on the natural history of treated RE are few. Although proton pump inhibitors (PPIs) as the first-line treatment provide notable symptomatic relief, disordered gut microbiota has been observed among PPI users. Probiotics are commonly administered to patients to regulate the disordered intestinal flora. AIM To evaluate the therapeutic effects in RE patients treated with a combination of esomeprazole and probiotics [ Bacillus subtilis ( B. subtilis ) and Enterococcus faecium ( E. faecium )]. METHODS One hundred and thirty-four RE patients were randomized into two groups of 67 subjects each. The probiotics group was administered with esomeprazole 20 mg b.i.d . and live combined B. subtilis and E. faecium enteric-coated capsules 500 mg t.i.d . for eight weeks; the placebo group was administered with esomeprazole 20 mg b.i.d . and placebo for eight weeks. Subsequently, 12-wk follow-up was carried out on patients who achieved both endoscopic and clinical cure. Endoscopy, reflux diagnostic questionnaire (RDQ), gastrointestinal symptom rating scale (GSRS), and lactulose hydrogen breath test were performed to evaluate the therapeutic effects. A difference of P < 0.05 was considered statistically significant. RESULTS Sixty-six patients in the probiotics group and 64 patients in the placebo group completed the 8-wk treatment. The healing rate and RDQ score had no significant difference between the two groups ( P > 0.05). However, the GSRS diarrhea syndrome score was decreased significantly in the probiotics group ( P = 0.002), and the small intestinal bacterial overgrowth negative rate in the probiotics group was significantly higher than that in the placebo group ( P = 0.002). Of 114 endoscopically and clinically cured patients, 96 completed the follow-up. The log-rank test showed that the time to relapse was shorter in the placebo group than in the probiotics group ( P = 0.041). Furthermore, the therapy had a significant influence on relapse time, and the risk of relapse in the probiotics group was lower than that in the placebo group at any time point during the 12-wk follow-up (hazard ratio = 0.52, P = 0.033). CONCLUSION Esomeprazole combined with probiotics ( B. subtilis and E. faecium ) have a beneficial effect on RE treatment and patient management. ...

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Factores de riesgo asociados a recaída de enfermedad por reflujo gastroesofágico en pacientes de primer nivel de atención exitosamente tratados con inhibidor de la bomba de protones

Abstract: The relapse rate after short-term treatment with omeprazole was high. The consumption of citrus fruits and NSAIDs increased the possibility of GERD relapse.

Cited by 8 publications

References 23 publications

Risk Factors for Gastroesophageal Reflux Disease in Saudi Arabia

Risk Factors for Gastroesophageal Reflux Disease in Saudi Arabia

Education could be a protective factor against gastro-oesophageal reflux disease: a Mendelian randomization study

Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial

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